Abstract: The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia.

Abstract: A downhole tool, a retrievable bridge plug system, and a method. The downhole tool includes a release mandrel, a plurality of slips disposed at least partially around the release mandrel, an upper cone disposed at least partially around the release mandrel and on a first axial side of the plurality of slips, a lower cone disposed at least partially around the outer mandrel and on a second axial side of the plurality of slips, and a collet positioned axially and radially between the release mandrel and the lower cone. The collet is configured to prevent downward movement of the lower cone relative to the release mandrel at least when the downhole tool is in a run-in configuration and when the downhole tool is in a set configuration.

Abstract: A downhole tool, a retrievable bridge plug system, and a method. The downhole tool includes a release mandrel, a plurality of slips disposed at least partially around the release mandrel, an upper cone disposed at least partially around the release mandrel and on a first axial side of the plurality of slips, a lower cone disposed at least partially around the outer mandrel and on a second axial side of the plurality of slips, and a collet positioned axially and radially between the release mandrel and the lower cone. The collet is configured to prevent downward movement of the lower cone relative to the release mandrel at least when the downhole tool is in a run-in configuration and when the downhole tool is in a set configuration.

Abstract: Methods and apparatuses used in locking downhole tools such as locking packers, bridge plugs, and frac plugs are shown herein that decrease the loss of energy during pack-off.

Abstract: A device (15) for measuring the level of a fluid (24) in a container (17) comprising a frame assembly having a first arm (18) and a second arm (19), the first and second arms configured to move from a first folded position (20) to a second expanded position (21), a probe element (22) supported between the first arm and the second arm, the probe element having a sensing portion (34, 35) between the arms when the arms are in the second expanded position, the sensing portion configured to have a length (25) in contact with the fluid, an electrical circuit (26, 29) connected to the probe element, the probe element and the circuit forming a capacitor having a capacitance which is a function of the length of the probe that is in contact with the fluid, and the circuit configured to produce an output signal as a function of the capacitance.

Abstract: A downhole tool for providing a pressure differential between sub-assemblies, the downhole tool including an elongated body, a tubular assembly disposed within the elongated body, the tubular assembly including a central flowbore with an inner diameter and a central longitudinal axis, a camming device, an actuator member located below the tubular assembly, having a dual-bore configuration, the actuator member including a first bore, a second bore, and a concave seating surface formed within the second bore for receiving a obstructing device, wherein the first bore and the second bore are oriented 90 degrees to one another so that fluid may flow through the actuator while it is in either a first or a second position, and a stationary sleeve concentrically disposed between the actuator member and the elongated body is disclosed.

Abstract: A downhole tool for isolating zones in a well, the tool including a mandrel, a sealing element disposed around the mandrel, and an upper cone disposed around the mandrel proximate an upper end of the sealing element. The tool further including an upper slip assembly disposed around the mandrel adjacent a sloped surface of the upper cone, a lower cone disposed around the mandrel proximate a lower end of the sealing element, a lower slip assembly disposed around the mandrel adjacent a sloped surface of the lower cone, and two element end rings. Further, the tool includes a first element end ring disposed adjacent the upper end of the sealing element and a second element end ring disposed adjacent the lower end of the sealing element, and two element barrier assemblies, each assembly disposed adjacent one of the two element end rings.

Abstract: A drillable bridge plug comprising a mandrel, a sealing element disposed around the mandrel, a plurality of backup rings adjacent the sealing element, a lower slip assembly disposed around the mandrel, an upper slip assembly disposed around the mandrel, an upper cone adjacent the upper slip assembly and engaged with the mandrel with at least one axial locking apparatus and at least one rotational locking apparatus, and a lower cone adjacent the lower slip assembly and engaged with the mandrel with at least one axial locking apparatus and at least one rotational locking apparatus. A drillable bridge plug comprising a mandrel and at least one slip assembly at least partially made of a material having less than 10% elongation.

Abstract: A downhole tool for isolating zones in a well, the tool including a mandrel, a sealing element disposed around the mandrel, an upper cone disposed around the mandrel proximate an upper end of the sealing element, an upper slip assembly disposed around the mandrel adjacent a sloped surface of the upper cone, a lower cone disposed around the mandrel proximate a lower end of the sealing element, a lower slip assembly disposed around the mandrel adjacent a sloped surface of the lower cone, two element end rings, a first element end ring disposed adjacent the upper end of the sealing element and a second element end ring disposed adjacent the lower end of the sealing element, and two element barrier assemblies, each assembly disposed adjacent one of the two element end rings is disclosed.

Abstract: A downhole tool for isolating zones in a well includes a mandrel, a sealing element disposed around the mandrel, an upper cone disposed around the mandrel proximate an upper end of the sealing element, an upper slip assembly disposed around the mandrel adjacent a sloped surface of the upper cone, a lower cone disposed around the mandrel proximate a lower end of the sealing element, a lower slip assembly disposed around the mandrel adjacent a sloped surface of the lower cone, and two element end rings. The two element end rings include a first element end ring disposed adjacent the upper end of the sealing element and a second element end ring disposed adjacent the lower end of the sealing element. The downhole tool includes two element barrier assemblies; each assembly disposed adjacent one of the two element end rings.

Abstract: A downhole tool for providing a pressure differential between sub-assemblies, the downhole tool including an elongated body, a tubular assembly disposed within the elongated body, the tubular assembly including a central flowbore with an inner diameter and a central longitudinal axis, a camming device, an actuator member located below the tubular assembly, having a dual-bore configuration, the actuator member including a first bore, a second bore, and a concave seating surface formed within the second bore for receiving a obstructing device, wherein the first bore and the second bore are oriented 90 degrees to one another so that fluid may flow through the actuator while it is in either a first or a second position, and a stationary sleeve concentrically disposed between the actuator member and the elongated body is disclosed.

Abstract: An anchoring device to secure a packer assembly within a casing, including a frangible ring having a plurality of grips on an outer circumference, wherein a first end of the frangible ring includes a plurality of circumferentially spaced slots, and an expansion ring having a plurality of castellations configured to engage the slots of the first end of the frangible ring is disclosed. A method to secure a packer assembly in a casing, including engaging a plurality of arcuate segments of a segmented ring with a plurality of slots in a first end of a frangible ring, engaging a plurality of castellations of an expansion ring with the plurality of slots on a second end of the frangible ring, and moving the expansion ring in an axial direction towards the frangible ring and splitting the frangible ring into a plurality of slip segments, thereby radially extending the plurality of slip segments and segmented ring into the casing is also disclosed.

Abstract: A drillable bridge plug comprising a mandrel, a sealing element disposed around the mandrel, a plurality of backup rings adjacent the sealing element, a lower slip assembly disposed around the mandrel, an upper slip assembly disposed around the mandrel, an upper cone adjacent the upper slip assembly and engaged with the mandrel with at least one axial locking apparatus and at least one rotational locking apparatus, and a lower cone adjacent the lower slip assembly and engaged with the mandrel with at least one axial locking apparatus and at least one rotational locking apparatus. A drillable bridge plug comprising a mandrel and at least one slip assembly at least partially made of a material having less than 10% elongation.

Abstract: A downhole tool includes a mandrel, a sealing element disposed around the mandrel, an upper cone disposed above the sealing element and a lower cone disposed below the sealing element, an upper slip assembly disposed above the upper cone and a lower slip assembly disposed below the sealing element, at least one lock ring configured to maintain energization of the sealing element when the downhole tool is set, and a secondary lock that couple the upper cone with the at least one lock ring. A method of increasing pack-off force of a downhole tool includes setting the downhole tool and energizing further the sealing element by applying a differential pressure to the downhole tool.

Abstract: An anchoring device to secure a packer assembly within a casing, including a frangible ring having a plurality of grips on an outer circumference, wherein a first end of the frangible ring includes a plurality of circumferentially spaced slots, and an expansion ring having a plurality of castellations configured to engage the slots of the first end of the frangible ring is disclosed. A method to secure a packer assembly in a casing, including engaging a plurality of arcuate segments of a segmented ring with a plurality of slots in a first end of a frangible ring, engaging a plurality of castellations of an expansion ring with the plurality of slots on a second end of the frangible ring, and moving the expansion ring in an axial direction towards the frangible ring and splitting the frangible ring into a plurality of slip segments, thereby radially extending the plurality of slip segments and segmented ring into the casing is also disclosed.

Abstract: A drillable bridge plug comprising a mandrel, a sealing element disposed around the mandrel, a plurality of backup rings adjacent the sealing element, a lower slip assembly disposed around the mandrel, an upper slip assembly disposed around the mandrel, an upper cone adjacent the upper slip assembly and engaged with the mandrel with at least one axial locking apparatus and at least one rotational locking apparatus, and a lower cone adjacent the lower slip assembly and engaged with the mandrel with at least one axial locking apparatus and at least one rotational locking apparatus. A drillable bridge plug comprising a mandrel and at least one slip assembly at least partially made of a material having less than 10% elongation.

Abstract: A downhole tool for isolating zones in a well, the tool including a mandrel, a sealing element disposed around the mandrel, an upper cone disposed around the mandrel proximate an upper end of the sealing element, an upper slip assembly disposed around the mandrel adjacent a sloped surface of the upper cone, a lower cone disposed around the mandrel proximate a lower end of the sealing element, a lower slip assembly disposed around the mandrel adjacent a sloped surface of the lower cone, two element end rings, a first element end ring disposed adjacent the upper end of the sealing element and a second element end ring disposed adjacent the lower end of the sealing element, and two element barrier assemblies, each assembly disposed adjacent one of the two element end rings is disclosed.

Abstract: A downhole mill includes a plurality of cutters extending generally radially from a center region to a gage diameter, wherein the plurality of cutters includes a first serrated cutter blade having a plurality of peaks and valleys along its length. The plurality of cutters includes a second serrated cutter blade having a plurality of peaks and valleys along its length. The plurality of cutters includes a non-serrated cutter blade positioned upon the cutting face between the first serrated cutter blade and the second serrated cutter blade, wherein the peaks of the first serrated cutter blade is radially aligned with the valleys of the second serrated cutter blade. A pump-off sub configured to release a downhole mill includes a dovetail connection maintained by a c-ring in an expanded state.

Abstract: A well bore tool with a torsional resistant slip mechanism for resisting axial and torsional forces comprising a mandrel, a plurality of slips disposed about the circumference of the mandrel. The slips include a plurality of inserts oriented to resist axial forces and torsional forces. The tool also comprises a setting means adjacent each to slip for radially expanding and setting said slips.

Abstract: A well bore tool with a torsional resistant slip mechanism for resisting axial and torsional forces comprising a mandrel, a plurality of slips disposed about the circumference of the mandrel. The slips include a plurality of inserts oriented to resist axial forces and torsional forces. The tool also comprises a setting means adjacent each to slip for radially expanding and setting said slips.