Abstract: Aspects of the disclosure are directed towards generating a trajectory for use by a robot to perform an operation on a target object. A method includes a robot instructed to traverse a surface of the target object from the starting position and obtain sensor input from a sensor system of the robot using a first trajectory specified by a CAD file for the target object. Sensor input that includes a first height to the target object, a width of the seam, and a depth of the seam may be received. A second trajectory may be generated for traversing the surface of the target object and that modifies the first trajectory based on the sensor input. The robot may be instructed to move to the starting position and traverse the surface of the target object using the second trajectory and apply a sealant to the seam.

Abstract: A pump mechanism for dispensing a sealant is described. The pump mechanism can include a housing comprising a cavity; a tubing track arranged in the cavity, the tubing track having a curved surface inward from the housing; a tubing arranged in proximity to the curved surface of the tubing track; a rotor assembly arranged inward from the curved surface and the tubing, the rotor assembly comprising a rotor and a first roller in contact with the tubing, the first roller compressing the tubing to reduce fluidic communication between a first end and a second end of the tubing; a motor in operable communication with the rotor assembly; and a computing device configured to control a rotational speed of the rotor based on a velocity of a tool center point (TCP) of the robot.

Abstract: Aspects of the disclosure are directed towards generating a trajectory for use by a robot to perform an operation on a target object. A method includes a robot instructed to traverse a surface of the target object from the starting position and obtain sensor input from a sensor system of the robot using a first trajectory specified by a CAD file for the target object. Sensor input that includes a first height to the target object, a width of the seam, and a depth of the seam may be received. A second trajectory may be generated for traversing the surface of the target object and that modifies the first trajectory based on the sensor input. The robot may be instructed to move to the starting position and traverse the surface of the target object using the second trajectory and apply a sealant to the seam.

Abstract: An instrument for facilitating transseptal delivery of a cardiac therapeutic device is positionable in a left ventricle. The instrument includes an elongate shaft having a tubular lumen, the shaft having a proximal portion and a distal portion actively steerable between a generally straight position and a curved position. An external pull wire and an internal pull wire are each actuatable to move the distal portion to the curved position. The external pull wire extends internally through the proximal portion of the shaft and longitudinally along the exterior of the distal portion of the shaft, while the internal pull wire extends internally through the proximal portion of the shaft adjacent to the external pull wire, and extends internally through the distal portion of the shaft.

Abstract: A method for analyzing survivability of an infrastructure link includes determining an optimal path arrangement of the infrastructure link between two geographic locations; and determining a risk index associated with the determined optimal path arrangement based on one or more quantified cost factors and one or more quantified risk factors associated with the determined optimal path arrangement. The risk index represents a survivability of the infrastructure link.

Abstract: A computer-implemented method and a related system for determining seismic hazard related data. The method includes processing geological/seismological data associated with an area of unknown hazard using a simulation model, and determining simulated ground motion intensity data associated with the area of unknown hazard. The simulation model is determined based on geological/seismological data associated with an area of known hazard and ground motion intensity data associated with the area of known hazard. Alternatively, or additionally, the method includes processing simulated ground motion intensity data associated with the area of unknown hazard with another simulation model.

Abstract: A computer-implemented method and system for determining a path arrangement of an infrastructure link. The method includes receiving one or more inputs each indicative of a constraint; and processing the one or more inputs and a set of data based on a path arrangement determination model. The set of data includes data representing one or more factors affecting the path arrangement. The method also includes determining, based on the processing, the path arrangement of the infrastructure link.

Abstract: A computer-implemented method and a related system for determining seismic hazard related data. The method includes processing geological/seismological data associated with an area of unknown hazard using a simulation model, and determining simulated ground motion intensity data associated with the area of unknown hazard. The simulation model is determined based on geological/seismological data associated with an area of known hazard and ground motion intensity data associated with the area of known hazard. Alternatively, or additionally, the method includes processing simulated ground motion intensity data associated with the area of unknown hazard with another simulation model.

Abstract: A computer-implemented method and system for determining a path arrangement of an infrastructure link. The method includes receiving one or more inputs each indicative of a constraint; and processing the one or more inputs and a set of data based on a path arrangement determination model. The set of data includes data representing one or more factors affecting the path arrangement. The method also includes determining, based on the processing, the path arrangement of the infrastructure link.

Abstract: A method for determining an optimal path arrangement of an infrastructure link network, and a related system for performing the method. The method includes modelling a geographic terrain having a plurality of geographic locations to be connected with each other via an infrastructure link network; modelling each of a laying cost and a repair rate as a respective function affecting the optimal path arrangement of the infrastructure link network; applying a respective weighting to each of the functions to determine a minimized cost function; and determining, based on the determined minimized cost function, the optimal path arrangement connecting the plurality of geographical locations. The determined optimal path arrangement of the infrastructure link network includes a trunk-and-branch topology with a plurality of infrastructure links and one or more connection points connecting the infrastructure links.

Abstract: A method for determining an optimal path arrangement of an infrastructure link network, and a related system for performing the method. The method includes modelling a geographic terrain having a plurality of geographic locations to be connected with each other via an infrastructure link network; modelling each of a laying cost and a repair rate as a respective function affecting the optimal path arrangement of the infrastructure link network; applying a respective weighting to each of the functions to determine a minimized cost function; and determining, based on the determined minimized cost function, the optimal path arrangement connecting the plurality of geographical locations. The determined optimal path arrangement of the infrastructure link network includes a trunk-and-branch topology with a plurality of infrastructure links and one or more connection points connecting the infrastructure links.

Abstract: A method for analyzing survivability of an infrastructure link includes determining an optimal path arrangement of the infrastructure link between two geographic locations; and determining a risk index associated with the determined optimal path arrangement based on one or more quantified cost factors and one or more quantified risk factors associated with the determined optimal path arrangement. The risk index represents a survivability of the infrastructure link.

Abstract: A method for determining an optimal laying arrangement of a new infrastructure link for connection from a new site to an existing infrastructure network includes modeling a terrain of a region around and at the new site and the existing infrastructure network near the new site; modeling each factor affecting the laying arrangement as a respective cost function; applying a respective weighting to each of the cost function to determine a life-cycle cost function; and determining, based on the determined life-cycle cost function, an optimized laying arrangement with minimal life-cycle cost from the new site to a connection point in the existing infrastructure network.

Abstract: A method for determining an optimal laying arrangement of a new infrastructure link for connection from a new site to an existing infrastructure network includes modeling a terrain of a region around and at the new site and the existing infrastructure network near the new site; modeling each factor affecting the laying arrangement as a respective cost function; applying a respective weighting to each of the cost function to determine a life-cycle cost function; and determining, based on the determined life-cycle cost function, an optimized laying arrangement with minimal life-cycle cost from the new site to a connection point in the existing infrastructure network.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a likelihood that an individual is ready. The methods, systems, and apparatus include actions of obtaining health data for a set of individuals, providing the health data for the set of individuals to a readiness classifier that classifies individuals as either ready or as not ready, obtaining, from the readiness classifier, classifications for each of the individuals of the set of individuals, generating, from the classifications for each of the individuals of the first set of individuals, a readiness risk scoring model that determines a risk that an individual is not ready from health data of the individual, obtaining health data regarding a particular individual, and determining, from the health data regarding the particular individual and the readiness risk scoring model, a risk that the particular individual is not ready.

Abstract: A method of making pellets is provided. The method may include grinding a biomass to a smaller particle size, forming a ground biomass. The ground biomass may then be placed within a conditioner and steamed for more than about 20 seconds, forming a steamed and ground biomass. The steamed and ground biomass may be formed into a plurality of pellets using a die having a larger open area.

Abstract: The invention provides combretastatin A-4 like compounds that are modified to have enhanced tubulin binding activity and in some embodiments the ability to promote accumulation in the vasculature undergoing angiogenesis (homing activity). The compounds are based on the combretastatin A-4 skeletal structure having a tubulin-binding pharmacophore comprising two fused rings (A and B rings) in which the B ring is substituted with (a) an aromatic ring structure (C ring) and (b) a second substituent/functional group that comes off the B ring. The aromatic ring structure is typically a six membered ring phenolic or aniline structure, or may also be a fused ring structure such as a substituted or unsubstituted naphthalene.

Abstract: A method of obtaining information about at least one target, includes transmitting a stepped frequency signal, obtaining a return radar signal corresponding to the transmitted stepped frequency signal from at least one target, bandpass filtering the return radar signal based on the frequencies of the transmitted frequency signal, converting the bandpass filtered return radar signal to a digital bandpass filtered return radar signal, and digitally mixing the digital bandpass filtered return radar signal with a digital mixing signal related to the stepped frequency signal to obtain information about the at least one target.

Abstract: A method for providing to a real estate purchaser such has a home buyer an indicia such as a printed card or an entry onto a portal signifying to those concerned in the industry such as a seller or a seller's representative that the home buyer has provided the information required for obtaining a loan, that the information including the financial information has been independently verified and has been processed through an appropriate approval process such as an automated underwriting system and has been approved for a predetermined loan amount and that the home buyer's condition is such that the loan is ready to close.