Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.

Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.

Abstract: The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that the adhesion molecule CD99L2 mediates TEM of leukocytes. CD99L2 is present on endothelial cells and leukocytes and mediates leukocyte-endothelial cell adhesion. Blockade of CD99L2 by use of a specific antibody blocks migration of leukocytes into a site of inflammation. CD99L2 shows functional analogy to the structurally-related molecule, CD99, inhibition of which, in conjunction with inhibition of PECAM, causes near total blockade of TEM. Thus, blocking CD99L2 on either endothelial cells or monocytes can block migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade can approach 100%. Therapeutic treatments involving inhibition of CD99L2 show significant promise in remediation of inflammatory conditions.

Abstract: The invention provides a renewable composite filter media for removal of particles from a fluid stream. The filter media includes a membrane filtration layer comprising a porous polymeric membrane having an upstream side and a downstream side relative to the direction of fluid flow, a first depth filtration media layer having an upstream side and a downstream side relative to the direction of fluid flow, the first depth filtration media layer being disposed on upstream side of the membrane filtration layer; and at least one additional depth filtration media layer removably attached to the upstream side of the first depth filtration media layer. In this aspect, the first depth filtration media layer may be removably attached to the membrane filtration layer.

Abstract: The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that the adhesion molecule CD99L2 mediates TEM of leukocytes. CD99L2 is present on endothelial cells and leukocytes and mediates leukocyte-endothelial cell adhesion. Blockade of CD99L2 by use of a specific antibody blocks migration of leukocytes into a site of inflammation. CD99L2 shows functional analogy to the structurally-related molecule, CD99, inhibition of which, in conjunction with inhibition of PECAM, causes near total blockade of TEM. Thus, blocking CD99L2 on either endothelial cells or monocytes can block migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade can approach 100%. Therapeutic treatments involving inhibition of CD99L2 show significant promise in remediation of inflammatory conditions.

Abstract: The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.

Abstract: The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.

Abstract: The invention concerns equipment for extracting root post prosthetic elements or implants, such as an instrument including two lever assembled together by a pivoting and non-intersecting articulation, each of the levers having a handle and an extracting branch extending on either side of the articulation such that when the two handles are brought closer together, the two extracting branches are spaced apart. The ends of the extracting branches of the instruments are curved so as to form an angle with the remaining part of the branches. There are U-shaped extracting end pieces designed to be removably positioned and pivotably mounted, at the curved ends of the extracting branches.

Abstract: An instrument for removing a crown by generating a couple of forces between the occlusal surface of the stump of the tooth and the basal surface of the crown. The instrument has an indented intermediate portion and a working part extending from a tapered intermediate portion and a handle. When inserted in a groove formed at the occlusal part of the stump along a plane substantially parallel to the occlusal surface of the crown, the working portion enables, by a physical action, exertion of a couple of forces between the respective occlusal surfaces of the stump and the basal surface of the crown. The working part is rotatable integrally and correspondingly with a rotation of the handle.

Abstract: A flexure endurant composition of an elastomer reinforced with a continuous phase of microporous, expanded polytetrafluoroethylene (ePTFE) having a ratio of elastomer to PTFE of approximately 1:1 to 50:1 on a volume basis. The composite is prepared by a coating process and the final articles are prepared by molding or vulcanizing. Such materials can be used to fabricate pump tubing, pump diaphragms, gaskets, bellows and other mechanical devices.

Abstract: The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.

Abstract: An instrument for setting a crown or a sealed prosthesis on a natural or prosthetic support by generating a couple of forces between the occlusal surface of the stump and the basal surface of the crown. The instrument includes an indented intermediate portion and a working portion, which may include an extension of a handle and a tapered intermediate portion. When inserted in a groove previously performed by the practitioner at a supposed level of the occlusal part of the stump along a plane substantially parallel to the occlusal surface of the crown, the working portion enables, by a physical action, exertion of a couple of forces between the respective occlusal surfaces of the stump and the basal surface of the crown. The couple of forces being generated subtantially in the vertical axis of the tooth or implant, the instrument enables to limit the traumas for the patient, to preserve the support base, to safeguard the prosthesis for future resetting.

Abstract: A flexure endurant composition of an elastomer reinforced with a continuous phase of microporous, expanded polytetrafluoroethylene (ePTFE) having a ratio of elastomer to PTFE of approximately 1:1 to 50:1 on a volume basis. The composite is prepared by a coating process and the final articles are prepared by molding or vulcanizing. Such materials can be used to fabricate pump tubing, pump diaphragms, gaskets, bellows and other mechanical devices.

Abstract: A flexure endurant composition of an elastomer reinforced with a continuous phase of microporous, expanded polytetrafluoroethylene (ePTFE) having a ratio of elastomer to PTFE of approximately 1:1 to 50:1 on a volume basis. The composite is prepared by a coating process and the final articles are prepared by molding or vulcanizing. Such materials can be used to fabricate pump tubing, pump diaphragms, gaskets, bellows and other mechanical devices.