Abstract: A tool, e.g. a downhole tool, utilizes at least one actuator which may be actuated rapidly between positions during operation of the tool. The actuator is moved via flow of an actuating fluid controlled by a main valve which, in turn, is controlled via a pilot valve. The pilot valve is operated to selectively control flow of the actuating fluid to the main valve so as to shift the main valve between desired operational positions.

Abstract: A torsional damping system includes a housing having an interior space. An inertia ring is located in the interior space, and a torsion fluid is located between the inertia ring and the housing. The inertia ring is rotatably installed relative to the housing. As the housing oscillates, the inertia ring damps at least a portion of the oscillation. The torsional damping system may be included in a downhole tool or bottomhole assembly, and used to damp oscillations along a drill string or along the bottomhole assembly, including between a downhole motor and a cutting tool.

Abstract: A tool, e.g. a downhole tool, utilizes at least one actuator which may be actuated rapidly between positions during operation of the tool. The actuator is moved via flow of an actuating fluid controlled by a main valve which, in turn, is controlled via a pilot valve. The pilot valve is operated to selectively control flow of the actuating fluid to the main valve so as to shift the main valve between desired operational positions.

Abstract: A tool, e.g. a downhole tool, utilizes at least one actuator which may be actuated rapidly between positions during operation of the tool. The actuator is moved via flow of an actuating fluid controlled by a main valve which, in turn, is controlled via a pilot valve. The pilot valve is operated to selectively control flow of the actuating fluid to the main valve so as to shift the main valve between desired operational positions.

Abstract: A tool, e.g. a downhole tool, utilizes at least one actuator which may be actuated rapidly between positions during operation of the tool. The actuator is moved via flow of an actuating fluid controlled by a main valve which, in turn, is controlled via a pilot valve. The pilot valve is operated to selectively control flow of the actuating fluid to the main valve so as to shift the main valve between desired operational positions.

Abstract: The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRP? that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human SIRP? transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of the growth and differentiation of hematopoietic and immune cells, for the in vivo assessment of an immune response, for the in vivo evaluation of vaccines and vaccination regimens, for in vivo production and collection of immune mediators, including human antibodies, and for use in testing the effect of agents that modulate hematopoietic and immune cell function.

Abstract: The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRP? that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human SIRP? transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of the growth and differentiation of hematopoietic and immune cells, for the in vivo assessment of an immune response, for the in vivo evaluation of vaccines and vaccination regimens, for in vivo production and collection of immune mediators, including human antibodies, and for use in testing the effect of agents that modulate hematopoietic and immune cell function.

Abstract: The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRP? that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human SIRP? transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of the growth and differentiation of hematopoietic and immune cells, for the in vivo assessment of an immune response, for the in vivo evaluation of vaccines and vaccination regimens, for in vivo production and collection of immune mediators, including human antibodies, and for use in testing the effect of agents that modulate hematopoietic and immune cell function.

Abstract: The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRP? that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human SIRP? transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of the growth and differentiation of hematopoietic and immune cells, for the in vivo assessment of an immune response, for the in vivo evaluation of vaccines and vaccination regimens, for in vivo production and collection of immune mediators, including human antibodies, and for use in testing the effect of agents that modulate hematopoietic and immune cell function.