Abstract: A networked system for providing transcranial magnetic stimulation (TMS) based on analyzed electroencephalogram (EEG) data is disclosed. The networked system interfaces with portable neuro¬electroencephalogram synchronization therapy (NEST) devices for capturing EEG data from a patient. The network also may also include an electrophysiology database and customized TMS treatment system for receiving the EEG data from the portable NEST system. The electrophysiology database and customized TMS treatment system are configurable and operable to determine a TMS treatment based on the received EEG data. The portable NEST system may provide synchronized TMS based on the determined TMS treatment.

Abstract: A method for providing transcranial magnetic stimulation (TMS) based on electroencephalogram (EEG) data. The method may include use of a portable neuro-electroencephalogram synchronization therapy (NEST) system for capturing EEG data from a patient. The method may also include use of an electrophysiology database and customized TMS treatment system for receiving the EEG data from the portable NEST system. The electrophysiology database and customized TMS treatment system may determine a TMS treatment based on the received EEG data. The portable NEST system may deliver synchronized TMS based on the determined TMS treatment.

Abstract: Systems and methods are described, which provides electrical stimulation to a person, while also facilitating delivery of a drug through the system to a target region of the brain. The electrical stimulation to the target region of the brain increases a permeability of a blood brain barrier.

Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: A water heater includes a tank configured to hold a fluid, a sacrificial anode located within the tank, and a controller coupled to the sacrificial anode. The controller is configured to selectively complete and break an electrical circuit connecting the tank and the sacrificial anode. The controller is also configured to measure a shorted anode current through the electrical circuit, to determine a modulation duty cycle based on a current setpoint and the measured shorted anode current, and to repeatedly complete and break the electrical circuit using the modulation duty cycle.

Abstract: A method of treating a subject that includes measuring at least one alpha burst associated with the subject's brain, determining at least one intrinsic frequency of the subject's brain based on the at least one measured alpha burst, selecting a stimulation frequency based on the at least one intrinsic frequency of the subject's brain, and providing a stimulation treatment at the stimulation frequency close to a head of the subject to influence at least one alpha burst parameter of the subject's brain.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: A cleaning brush includes first and second rigid base parts which are coupled together by a coupler. Each base part has bristles extending therefrom. Free ends of the bristles extending from the first base part face free ends of the bristles extending from the second base part.

Abstract: A system for generating a non-fungible token (NFT) associated with cognitive data. The system includes at least one memory storing computer-executable instructions and at least one processor for executing the instructions stored on the memory. Execution of the instructions programs the at least one processor to perform operations that include receiving cognitive data collected from a subject, the cognitive data being collected via at least one collection device, and generating an NFT based on the cognitive data, the NFT including a description of the NFT and a viewable representation of the cognitive data.

Abstract: Disclosed are nucleic acid preserving compositions and methods of manufacturing and using the same, particularly for detection of COVID-19 virus. Compositions include a carrier, a chaotropic agent, a buffering agent, a chelating agent, a surfactant, an alcohol, an acid, and a mucolytic agent. Compositions as aqueous solutions can include water as a carrier. Preferred embodiments include water, guanidine thiocyanate, Tris, EDTA, SLS, SDA 3C, HCl, and N-acetyl-L-cysteine. Some embodiments include a colored dye as a visual indicator. Kits include the composition disposed in a portion of a biological sample collection apparatus. Methods of manufacturing include combining the components into a mixture, such as an aqueous solution. Methods of use include providing a biological sample that includes nucleic acid and contacting the biological sample with the composition. Detection of COVID-19 virus is demonstrated. Compositions also preserve and stabilize human nucleic acid for subsequent analysis.

Abstract: A method and device is described, which provides electrical stimulation to the brain of a person, where the device comprises an external portion and at least one implantable portion. The external portion provides the energy source for stimulation to the implantable portions. The implantable portions provide at least two conductive paths through the skull and use the skull's high impedance to generate a current loop with the focus of stimulation lying in the current path.

Abstract: A method is described, which provides electrical stimulation to a person, where the current flows from a subcranial electrode, through a target brain region, through a separate conductive path, and back to a subcutaneous electrode, and where the parameters of the electric current pulses are set to influence the resonant properties of the brain.

Abstract: High frequency repetitive magnetic pulses may be used to treat pain in the foot of a person by relaxing the muscle and reducing communication of pain signals by neurons in the treatment region. A device is disclosed, which is floor mounted and incorporates a cooling mechanism and heat sink to allow high frequency magnetic stimulation to the person's foot.

Abstract: The present disclosure provides compounds of Formula I, Ia, Ib, Ib-1, Ib-2, Ic, Ic-1, Id-1, and Id-2. Compounds of Formula I, Ia, Ib, Ib-1, Ib-2, Ic, Ic-1, Id-1, and Id-2 may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: A temperature sensor assembly for measuring a gas temperature in a gas flow stream includes a first substrate having a first surface configured to be connected to a thermally conductive structure in a gas path, a first temperature sensor mounted to the first substrate a first distance from the first surface, and a second temperature sensor mounted to the first substrate a second distance from the first surface. The second distance is less than the first distance. The first and second temperature sensors are arranged along a temperature gradient.

Abstract: Methods and apparatus for self-assembled monolayer (SAM) deposition are provided herein. In some embodiments, an apparatus for self-assembled monolayer (SAM) deposition includes: a chamber enclosing a processing volume; a substrate support disposed in the chamber and configured to support a substrate in the processing volume; a gas distribution system coupled to the chamber and configured to distribute a process gas into the processing volume; a first SAM precursor source fluidly coupled to the gas distribution system to provide a first SAM precursor as a part of the process gas; and a second SAM precursor source fluidly coupled to the gas distribution system to provide a second SAM precursor, different than the first SAM precursor, as a part of the process gas, wherein the first and second SAM precursor sources are independently controllable to control a relative percentage of the first and second SAM precursors in the process gas with respect to each other.

Abstract: The present disclosure provides piperazine substituted fused azadecalin compounds of Formula J, I, Ia, Ib, Ib-1, Ib-2, Ic and Id for use in pharmaceutical formulations, and for modulating glucocorticoid receptors.

Abstract: Exemplary embodiments described herein provide systems and methods for administer multiple stimulus to a patient in order to improve the efficacy of the administered stimulus on the brain activity of the patient. Exemplary embodiments described herein may combined magnetic stimulation along with sensory stimulation to influence the intrinsic frequency of an EEG band of a person.

Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.