Abstract: The present invention relates to methods of treating solid cancers and hematological malignances using MDM2 degraders.

Abstract: An electronic device includes a circuit board having heat generating components thereon. A heat sink with air current generating electric device assembly lies over the circuit board, through which heat from the circuit board and the components thereon is dispersed. The assembly includes a heat sink having a solid central core and a plurality of fins protruding from the core. An air current generating electric device is disposed over the heat sink and having an air intake facing a top of the heat sink and an exhaust opening directed parallel to a plane of the circuit board. An air duct extends from the exhaust opening of the air current generating electric device to exhaust apertures on at least one side wall of the electronic device.

Abstract: The invention is an illumination system for a logo (20) on the front of an electronic device (1) such as a set top box. The logo (20) is part of a light pipe (23) and the logo (20) is illuminated by projecting light on the front surface (24) of the light pipe (23). The front surface (24) is textured or tinted to evenly distribute the light to a viewer. The light source (11) for illuminating the logo (20) is positioned at an entrance end of the light pipe (23) as shown in the figure. The shape of the light pipe (23) is substantially uniform throughout the length of the light pipe (23) and the shape is substantially the shape of the logo (20). The light pipe (23) can have a cut away region near the front surface to create localized lighting contrasts.

Abstract: An electronic device includes a cover for one or more heat generating components, with the cover providing at least a combined conductive, convective, and radiant cooling for the heat generating components while maintaining the device within a prescribed temperature range. Conductive cooling is realized by providing thermal coupling between each of two or more depression regions in the cover and one or more heat generating components. Appropriate placement of air inlets and outlets through the cover provides convective cooling of the heat generating components and the thermally coupled depression regions. Heat from the heat generating components thermally coupled to one depression region is effectively isolated from heat generated by other heat generating components thermally coupled to another adjacent depression region at least in part via the air outlets through an interior region between the two adjacent depression regions.

Abstract: The present principles of the embodiments generally relate to an apparatus and a method for bosses such as, for example, screw bosses, serving for multiple purposes. In one exemplary embodiment, a boss comprising a plurality of ribs is mated with a guide comprising a plurality of slots to resist twisting motion of the screw boss when a screw is inserted into the screw boss.

Abstract: A light pipe bracket (6) for an electronic device is provided that comprises a planar main body, light pipes (13) each having a proximal end and a distal end in which the light pipe extends from the distal end at the planar main body toward the distal end, and circuit board holding means (7) that support at least a portion of a circuit in the electronic device.

Abstract: There is provided an electronic device. The electronic device includes a circuit board having heat generating components thereon. The electronic device further includes spring clips or bend tabs. The electronic device also includes a heat sink, disposed over the circuit board, through which heat from the circuit board and the components thereon is released. The heat sink has a generally flat horizontal base and a series of vertically directed fins. The heat sink is secured to at least one of the circuit board and at least one of the components thereon by the spring clips or bend tabs being positioned at a periphery of the horizontal base. The spring clips or bend tabs have distal contact prongs that contact and apply downward force on the horizontal base.

Abstract: An electronic device is provided. The electronic device includes a circuit board having heat generating components thereon. The electronic device further includes a heat sink with air current generating electric device assembly, disposed over the circuit board, through which heat from the circuit board and the components thereon is released. The heat sink with air current generating electric device assembly includes a heat sink having a solid central core and a plurality of fins protruding from the core. The heat sink with air current generating electric device assembly further includes an air current generating electric device disposed over the heat sink and having an air intake facing a top of the heat sink and an exhaust opening directed parallel to a plane of the circuit board.

Abstract: An electronic device is described including a sliding vertical door, the sliding vertical door having a top, a bottom, and two vertical sides, wherein each of the two vertical sides has a locking latch at a bottom edge of each of the two vertical sides, the locking latch being between two vertical encouraging slots in each of the two vertical sides of the sliding vertical door, and wherein the siding vertical door has a front face, the front face of the sliding vertical door having a door handle positioned at, near or adjacent to the bottom of the sliding vertical door, the door handle being centered horizontally on the sliding vertical door and a sliding door bay, the sliding door bay having a bottom edge, the sliding door bay having side walls, the side walls having grooves therein.

Abstract: An electronic device includes a cover for one or more heat generating components, with the cover providing at least a combined conductive, convective, and radiant cooling for the heat generating components while maintaining the device within a prescribed temperature range. Conductive cooling is realized by providing thermal coupling between each of two or more depression regions in the cover and one or more heat generating components. Appropriate placement of air inlets and outlets through the cover provides convective cooling of the heat generating components and the thermally coupled depression regions. Heat from the heat generating components thermally coupled to one depression region is effectively isolated from heat generated by other heat generating components thermally coupled to another adjacent depression region at least in part via the air outlets through an interior region between the two adjacent depression regions.

Abstract: An electronic device includes a circuit board having heat generating components thereon. A heat sink with air current generating electric device assembly lies over the circuit board, through which heat from the circuit board and the components thereon is dispersed. The assembly includes a heat sink having a solid central core and a plurality of fins protruding from the core. An air current generating electric device is disposed over the heat sink and having an air intake facing a top of the heat sink and an exhaust opening directed parallel to a plane of the circuit board. An air duct extends from the exhaust opening of the air current generating electric device to exhaust apertures on at least one side wall of the electronic device.

Abstract: An electronic device is provided. The electronic device includes a circuit board having heat generating components thereon. The electronic device further includes a heat sink with air current generating electric device assembly, disposed over the circuit board, through which heat from the circuit board and the components thereon is released. The heat sink with air current generating electric device assembly includes a heat sink having a solid central core and a plurality of fins protruding from the core. The heat sink with air current generating electric device assembly further includes an air current generating electric device disposed over the heat sink and having an air intake facing a top of the heat sink and an exhaust opening directed parallel to a plane of the circuit board.

Abstract: There is provided an electronic device. The electronic device includes a circuit board having heat generating components thereon. The electronic device further includes spring clips or bend tabs. The electronic device also includes a heat sink, disposed over the circuit board, through which heat from the circuit board and the components thereon is released. The heat sink has a generally flat horizontal base and a series of vertically directed fins. The heat sink is secured to at least one of the circuit board and at least one of the components thereon by the spring clips or bend tabs being positioned at a periphery of the horizontal base. The spring clips or bend tabs have distal contact prongs that contact and apply downward force on the horizontal base.

Abstract: An electronic device is described including a sliding vertical door, the sliding vertical door having a top, a bottom, and two vertical sides, wherein each of the two vertical sides has a locking latch at a bottom edge of each of the two vertical sides, the locking latch being between two vertical encouraging slots in each of the two vertical sides of the sliding vertical door, and wherein the siding vertical door has a front face, the front face of the sliding vertical door having a door handle positioned at, near or adjacent to the bottom of the sliding vertical door, the door handle being centered horizontally on the sliding vertical door and a sliding door bay, the sliding door bay having a bottom edge, the sliding door bay having side walls, the side walls having grooves therein.

Abstract: A variable geometry turbine comprising: a housing; a turbine wheel supported in the housing for rotation; an annular inlet passage defined between respective inlet surfaces defined by an annular nozzle ring and a facing annular shroud; the nozzle ring can vary the size of the inlet passage; a circumferential array of inlet vanes; the shroud covering the opening of a shroud cavity defined by the housing inlet passage and inboard of the shroud, and defining a circumferential array of slots, the slots and shroud cavity being configured to receive said vanes accommodating movement of the nozzle ring; wherein the annular shroud comprises an outer flange, the outer flange defining a circumferential groove for receiving a retaining ring for securing the shroud in the opening of the shroud cavity and defined on an inboard side by a flange wall; wherein an annular flange rim extends axially inboard from said flange wall.

Abstract: A light pipe bracket (6) for an electronic device is provided that comprises a planar main body, light pipes (13) each having a proximal end and a distal end in which the light pipe extends from the distal end at the planar main body toward the distal end, and circuit board holding means (7) that support at least a portion of a circuit in the electronic device.

Abstract: A piston ring for sealing gas flow past a sliding cylinder is provided at the interface of the turbine and bearing housings, and is axially close to the turbine inlet. A V-band or similar connection joins the turbine and bearing housings but it is axially further away from the turbine inlet. The piston ring is provided with a spacer element between it and the bearing housing that is at least partially thermally decoupled from the bearing housing.

Abstract: A variable geometry turbine comprising: a housing; a turbine wheel supported in the housing for rotation; an annular inlet passage defined between respective inlet surfaces defined by an annular nozzle ring and a facing annular shroud; the nozzle ring can vary the size of the inlet passage; a circumferential array of inlet vanes; the shroud covering the opening of a shroud cavity defined by the housing inlet passage and inboard of the shroud, and defining a circumferential array of slots, the slots and shroud cavity being configured to receive said vanes accommodating movement of the nozzle ring; wherein the annular shroud comprises an outer flange, the outer flange defining a circumferential groove for receiving a retaining ring for securing the shroud in the opening of the shroud cavity and defined on an inboard side by a flange wall; wherein an annular flange rim extends axially inboard from said flange wall.

Abstract: A turbocharger having a cleaning port communicating between an external surface of the turbocharger housing and an internal cavity which communicates with a component of a gas flow control mechanism.

Abstract: The present invention relates to a device for measuring both the color and turbidity of a liquid sample. LEDs are used as light sources and reference detectors are included to control the output of the LEDs. The device is also capable of monitoring and correcting for fouling of optical surfaces. The device is intended to be installed in-line in a mains water supply line. The device can be used in domestic water meters or on sewage treatment sites to monitor the effluent discharged back to the river.