Abstract: Devices, systems and methods are described which are capable of producing vibrational energy within a lumen of a mammal and further including a measurement sensor capable of detecting, measuring and recording nerve activity in response to the vibrational energy.

Abstract: Devices, systems and methods are described which control blood pressure and nervous system activity by stimulating baroreceptors. By selectively and controllably activating baroreceptors and/or nerves, the present disclosure, according to some embodiments reduces blood pressure and alters the sympathetic nervous system; thereby minimizing deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device or other sensory activation device is positioned near a dermal bone to provide the treatment.