Patents by Inventor William Ronald Solvibile, Jr.

William Ronald Solvibile, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL STING AGONISTS
    Publication number: 20220048936
    Abstract: The present invention provides compounds of Formula I?: wherein W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
    Type: Application
    Filed: September 7, 2021
    Publication date: February 17, 2022
    Applicant: Venenum Biodesign, LLC
    Inventors: David J. DILLER, Axel METZGER, David E. KAELIN, JR., Steven PAGET, Chia-Yu HUANG, Brian F. MCGUINNESS, Audrey Julie HOSPITAL, William Ronald SOLVIBILE, JR.
  • Sting agonists
    Patent number: 11161864
    Abstract: The present invention provides compounds of Formula I?: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: November 2, 2021
    Assignee: VENENUM BIODESIGN, LLC
    Inventors: David J. Diller, Axel Metzger, David E. Kaelin, Jr., Steven Paget, Chia-Yu Huang, Brian F. Mcguinness, Audrey Julie Hospital, William Ronald Solvibile, Jr.
  • NOVEL STING AGONISTS
    Publication number: 20200131209
    Abstract: The present invention provides compounds of Formula I?: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
    Type: Application
    Filed: October 24, 2019
    Publication date: April 30, 2020
    Inventors: David J. Diller, Axel Metzger, David E. Kaelin, JR., Steven Paget, Chia-Yu Huang, Brian F. Mcguinness, Audrey Julie Hospital, William Ronald Solvibile, JR.
  • Amino-pyridines As Inhibitors Of Beta-secretase
    Publication number: 20100204245
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: April 20, 2010
    Publication date: August 12, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, JR., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Amino-pyridines as inhibitors of ?-secretase
    Patent number: 7732457
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: June 8, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, Jr., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators
    Patent number: 7459567
    Abstract: The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of ?-secretase (BACE) and for the treatment of ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: December 2, 2008
    Assignee: Wyeth
    Inventors: William Floyd Fobare, William Ronald Solvibile, Jr.