Patents by Inventor William S. Groene

William S. Groene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncolytic virus therapy
    Patent number: 8137663
    Abstract: A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: March 20, 2012
    Assignee: Wellstat Biologics Corporation
    Inventors: William S. Groene, Jeffrey A. Miller, Stephen N. Mueller
  • Treatment of neoplasms with viruses
    Patent number: 8105578
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: January 31, 2012
    Assignee: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Infection and treatment of neoplasms with vesicular stomatitis virus
    Patent number: 8043612
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: October 25, 2011
    Assignee: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Treatment of neoplasms with RNA viruses
    Patent number: 7780962
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: August 24, 2010
    Assignee: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Oncolytic virus therapy
    Patent number: 7595042
    Abstract: A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: September 29, 2009
    Assignee: Wellstat Biologics Corporation
    Inventors: William S. Groene, Jeffrey A. Miller, Stephen N. Mueller
  • ONCOLYTIC VIRUS THERAPY
    Publication number: 20090180994
    Abstract: A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
    Type: Application
    Filed: March 26, 2009
    Publication date: July 16, 2009
    Applicant: WELLSTAT BIOLOGICS CORPORATION
    Inventors: William S. Groene, Jeffrey A. Miller, Stephen N. Mueller
  • Treatment of neoplasms with viruses
    Publication number: 20090081161
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Application
    Filed: November 18, 2008
    Publication date: March 26, 2009
    Applicant: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. Von Borstel
  • Treatment of neoplasms with viruses
    Patent number: 7470426
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: December 30, 2008
    Assignee: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Oncolytic virus therapy
    Patent number: 7122182
    Abstract: A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: October 17, 2006
    Assignee: Wellstat Biologics Corporation
    Inventors: William S. Groene, Jeffrey A. Miller, Stephen N. Mueller
  • Treatment of neoplasms with viruses
    Publication number: 20030165465
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Application
    Filed: June 13, 2002
    Publication date: September 4, 2003
    Applicant: Pro-Virus, inc.
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Oncolytic virus therapy
    Publication number: 20030077819
    Abstract: A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
    Type: Application
    Filed: May 9, 2002
    Publication date: April 24, 2003
    Inventors: William S. Groene, Jeffrey A. Miller, Stephen N. Mueller
  • Treatment of neoplasms with viruses
    Publication number: 20030044384
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Application
    Filed: January 15, 2002
    Publication date: March 6, 2003
    Applicant: Pro-Virus, Inc.
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel