Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: A method for global navigation satellite system (GNSS)-based navigation may include retrieving terrain data for a geographical region and satellite orbit data for a GNSS comprising a plurality of satellites. Then, for of a plurality of time steps in a time period and for each of a plurality of lateral positions in the geographic region, a minimum height at which each satellite is visible from the lateral position at the time step may be determined. Unique combinations of satellites visible from the lateral position at the time step may be identified and error objects indicating GNSS performance quality corresponding to the unique combination of satellites may be generated. Performance quality information may be produced based on the one or more unique combinations of satellites and the respective one or more error objects. At least one aircraft may be operated based on this performance quality information.

Abstract: Disclosed are systems and methods for providing distributed security event monitoring. The system can include a central monitoring system and sensor devices positioned throughout a premises that passively detect conditions and emit signals guiding people on the premises when a security event is detected. The sensor devices can include suites of sensors and can transmit detected conditions to the central monitoring system.

Abstract: Various forms of skin irritations are treated with an appropriately configured and sized pad provided with a chilled skim milk additive which is useful for treating skin irritations such as diaper rash, irritations caused by incontinence, breast irritations experienced by nursing mothers, hemorrhoidal irritation, and skin irritations resulting from burns, insect bites, and the like. The irritated skin can be treated by applying the pad directly to the irritated skin. The treatment can continue during normal daily activities in various ways. The pad can take the form of breast pads that can be worn inside of a nursing bra, or it can take the form of an adhesive strip that can be adhered to the skin at the affected site. For treating diaper rash or incontinence-caused irritations, the pad can be placed in diapers or in suitable incontinence undergarments.

Abstract: A mini pad is provided with a chilled skim milk additive which is useful for reducing vulvar inflammation and lowering the acidity of a female's vulva which result from vaginal secretions which leak onto the tissue of the vulva. The mini pad can be provided with a self-contained cooling component which can be frozen or, when compressed and ruptured, will lower the temperature of the mini pad to provide the soothing cold. The skim milk can be incorporated into the mini pad in several different ways. The mini pad is useful for soothing and healing vulvar irritation, and it is mobile and can be easily used during normal daily activities without any problems whatsoever.

Abstract: A ceiling tile product and method in which a slurry formed mat primarily comprising mineral wool and binder is provided with a binder enhancement zone at its face. The binder enhancement zone can reduce the total required latex content, reduce the amount of finish or paint needed to achieve a commercially acceptable color and improve noise reduction.

Abstract: A method for relieving skin irritation caused by hair removal involves applying a chilled skim milk additive which to the irritated skin. The additive is applied to the skin on pads or similar carriers which are provided with a self-contained component that can be frozen or, when compressed and ruptured, will lower the temperature of the pads or carriers to provide the soothing cold. The skim milk can be incorporated into the pads or carriers in several different ways. One preferred way is to form a slurry of the dry skim milk in glycerin, which slurry is applied to the pads or carriers.

Abstract: Various forms of skin irritations are treated with an appropriately configured and sized pad provided with a chilled skim milk additive which is useful for treating skin irritations such as diaper rash, irritations caused by incontinence, breast irritations experienced by nursing mothers, hemorrhoidal irritation, and skin irritations resulting from burns, insect bites, and the like. The irritated skin can be treated by applying the pad directly to the irritated skin. The treatment can continue during normal daily activities in various ways. The pad can take the form of breast pads that can be worn inside of a nursing bra, or it can take the form of an adhesive strip that can be adhered to the skin at the affected site. For treating diaper rash or incontinence-caused irritations, the pad can be placed in diapers or in suitable incontinence undergarments.

Abstract: A mini pad is provided with a chilled skim milk additive which is useful for reducing vulvar inflammation and lowering the acidity of a female's vulva which result from vaginal secretions which leak onto the issue of the vulva. The mini pad can be provided with a self-contained component which can be frozen or, when compressed and ruptured, will lower the temperature of the mini pad to provide the soothing cold. The skim milk can be incorporated into the mini pad in several different ways. The mini pad is useful for soothing and healing vulvar irritation, and it is mobile and can be easily used during normal daily activities without any problems whatsoever.

Abstract: An aerosol dispenser utilizes a vertical container filled with a pressurized liquid. An actuator which has a nozzle is positioned on the valve stem which is located on the top of the container. The actuator when pressed vertically or horizontally allows a jet flow of liquid to spray from the nozzle. The dispenser is provided with apparatus for preventing formation of a residual liquid film after termination of the jet flow spray which would otherwise clog the nozzle.

Abstract: A ceiling tile product and method in which a slurry formed mat primarily comprising mineral wool and binder is provided with a binder enhancement zone at its face. The binder enhancement zone can reduce the total required latex content, reduce the amount of finish or paint needed to achieve a commercially acceptable color and improve noise reduction.

Abstract: A system for cleaning a particulate trap comprises locating the trap in a chamber and forcing cleaning air through the trap. The air and removed particulates is extracted from the trap towards a filter. The expelled air essentially without the removed particulates from the chamber, the removed particulates being essentially trapped in the filter. The trap is locatable about a longitudinal axis such that air is urged in a longitudinal direction through the trap. The trap is supportable on at least one rotatable roller to affect rotation about the axis. A motor and blower draws air from the chamber and an air pressure differential about the filter causes the particulate to be directed through the filter and excess air is pumped out of the blower by the motor operating the blower.

Abstract: Disclosed are a variety of methods and computer systems for use in the analysis of gene and protein expression data. Also disclosed are methods for the definition of the cellular state of cells and tissues from multidimensional physiological data such as those obtained from gene expression measurements with DNA microarrays. A variety of classification methods can be applied to expression data to achieve this goal. Demonstrated is the application of several statistical tools including Wilks' lambda ratio of within-group to total variance, Fisher Discriminant Analysis, and the misclassification error rate to the identification of discriminating genes and the overall classification of expression data. Examples from several different cases demonstrate the ability of the method to produce well-separated groups in the projection space representing distinct physiological states. The method can be augmented and is useful in disease diagnosis, drug screening and bioprocessing applications.

Abstract: A toothbrush is provided that includes a handle formed with an elongated cavity and a mouth opening at a terminus thereof. At least two stems consisting of a bar and a brushhead are hingedly supported at a first end of each bar within the elongated cavity. The toothbrush enables a user despite incorrect stroking to convert lateral motion into a corrected up and down movement of the bristles.