Abstract: The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g., a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.

Abstract: Provided herein are methods of treating a subject, such as a subject that has cancer, that include administering a therapeutically effective amount of a STING antagonist or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having: (I) a cancer cell having one or both of (i) decreased TREX1 level and/or activity, and (ii) increased cGAS/STING signaling pathway activity, e.g., as compared to a reference level, and/or (II) an elevated level of cGAMP in a serum or tumor sample obtained from the subject, e.g., as compared to a reference level.

Abstract: Provided herein are methods of treating a subject, such as a subject that has cancer, that include administering a therapeutically effective amount of a STING antagonist or a cGAS inhibitor or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having decreased SMARCB1 level and/or activity in a tumor sample obtained from the subject as compared to a reference level.

Abstract: The invention relates to a topical formulation in order to deliver an effective amount of broad-spectrum cannabidiol ointment, in conjunction with active ingredients, menthol and camphor. This invention is for the treatment of symptoms and improvement of sensation associated with peripheral neuropathy, particularly of the feet and hands. The present invention also provides for various topical application formulations.

Abstract: Combinations of nanoparticle-encapsulated cargo entities and methods of making and using same.

Abstract: The invention relates to a topical formulation in order to deliver an effective amount of broad-spectrum cannabidiol ointment, in conjunction with active ingredients, menthol and camphor. This invention is for the treatment of symptoms and improvement of sensation associated with peripheral neuropathy, particularly of the feet and hands. The present invention also provides for various topical application formulations.

Abstract: The invention relates to a topical formulation in order to deliver an effective amount of broad-spectrum cannabidiol ointment, in conjunction with active ingredients, menthol and camphor. This invention is for the treatment of symptoms and improvement of sensation associated with peripheral neuropathy, particularly of the feet and hands. The present invention also provides for various topical application formulations.

Abstract: The invention relates to a topical formulation in order to deliver an effective amount of broad-spectrum cannabidiol ointment, in conjunction with active ingredients, menthol and camphor. This invention is for the treatment of symptoms and improvement of sensation associated with peripheral neuropathy, particularly of the feet and hands. The present invention also provides for various topical application formulations.

Abstract: A concentrating solar power plant utilizes two heat transfer fluids. A first heat transfer fluid is heated in a field of concentrating solar collectors. A second heat transfer fluid is heated through a heat exchanger using heat imparted from the first heat transfer fluid. The second heat transfer fluid is then further heated, for example in a second field of concentrating solar collectors, and power is generated utilizing thermal energy extracted from the second heat transfer fluid. The second heat transfer fluid may be a solar salt, and may thus have a higher working temperature than the first heat transfer fluid. The power plant may realize the power generation efficiency improvements offered by utilizing a high temperature working fluid, while at least some of the plant does not require backup heating to protect against freezing events.

Abstract: A ram air turbine (RAT) prevents release of its turbine blades due an over-speed condition by detecting an over-speed condition with a turbine hub-mounted centrifugally operated trigger mechanism and rotating the blades to a fixed coarse pitch position with a release mechanism that responds to the trigger mechanism.

Abstract: A brake system for a ram air turbine (RAT) causes the RAT to slow or lock if the RAT achieves an over-speed condition with a centrifugal force operated trigger system that actuates a compression type brake pack to slow or lock the turbine hub

Abstract: An improved ram air turbine (RAT) prevents release of its turbine blades due an over-speed condition by detecting an over-speed condition with a trigger mechanism and rotating the blades to a fixed coarse pitch position with a release mechanism.