Abstract: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.

Abstract: Spent pyrophoric reaction catalyst from a reaction mixture is removed safely, cheaply, and rapidly using a single plate pressure filter. After hydrogenation, the reaction mixture is decanted, the desired hydrogenation product is removed, and catalyst-rich material which settles at the bottom of the vessel is delivered to a single plate pressure filter fitted with a filter bag 40 of permeable material. The spent catalyst is retained in the filter bag 40 and stored under water awaiting recovery. The filter apparatus 1 comprises a container having a domed base 2, a generally cylindrical sidewall 3 terminating in an upper rim 4 closed by a lid 5 having lifting lugs 6. The lid 5 is fixed in pressure-tight engagement with the sidewall 3 by flange engaging screw clamps 7 and an embedded polytetrafluoroethene gasket 8. The filter bag 40 is held in position by a band 11 and may be readily released for removal of the spent catalyst material. The bag 40 may be reused.

Abstract: Spent pyrophoric reaction catalyst from a reaction mixture is removed safely, cheaply, and rapidly using a single plate pressure filter. After hydrogenation, the reaction mixture is decanted, the desired hydrogenation product is removed, and catalyst-rich material which settles at the bottom of the vessel is delivered to a single plate pressure filter fitted with a filter bag 40 of permeable material. The spent catalyst is retained in the filter bag 40 and stored under water awaiting recovery. The filter apparatus 1 comprises a container having a domed base 2, a generally cylindrical sidewall 3 terminating in an upper rim 4 closed by a lid 5 having lifting lugs 6. The lid 5 is fixed in pressure-tight engagement with the sidewall 3 by flange engaging screw clamps 7 and an embedded polytetrafluoroethene gasket 8. The filter bag 40 is held in position by a band 11 and may be readily released for removal of the spent catalyst material. The bag 40 may be reused.

Abstract: A batch process for carrying out a hydrogenation reaction comprises mixing a pyrophoric catalyst with reactants and solvents to form a reaction mixture in a reaction vessel. Hydrogen is added to the reaction vessel. After hydrogenation, the desired hydrogenation product is removed from the reaction vessel and the pyrophoric catalyst-rich material from the reaction vessel is delivered to a pressure filter. Water is added to the pyrophoric catalyst-rich material in the filter and the spent pyrophoric material is removed from the pressure filter in a water wet form.

Abstract: A factory scale process for producing crystalline atorvastatin calcium includes the step of drying the isolated product in a vacuum pan dryer. The vacuum pan dryer has an agitator which is continuously rotated at a speed of approximately 1 rpm. High quality material is routinely and consistently produced with reduced cycle time.

Abstract: Spent pyrophoric reaction catalyst from a reaction mixture is removed safely, cheaply, and rapidly using a single plate pressure filter. After hydrogenation, the reaction mixture is decanted, the desired hydrogenation product is removed, and catalyst-rich material which settles at the bottom of the vessel is delivered to a single plate pressure filter fitted with a filter bag 40 of permeable material. The spent catalyst is retained in the filter bag 40 and stored under water awaiting recovery. The filter apparatus 1 comprises a container having a domed base 2, a generally cylindrical sidewall 3 terminating in an upper rim 4 closed by a lid 5 having lifting lugs 6. The lid 5 is fixed in pressure-tight engagement with the sidewall 3 by flange engaging screw clamps 7 and an embedded polytetrafluoroethene gasket 8. The filter bag 40 is held in position by a band 11 and may be readily released for removal of the spent catalyst material. The bag 40 may be reused.

Abstract: A factory scale process for producing crystalline atorvastatin calcium includes the step of drying the isolated product in a vacuum pan dryer. The vacuum pan dryer has an agitator which is continuously rotated at a speed of approximately 1 rpm. High quality material is routinely and consistently produced with reduced cycle time.

Abstract: An improved process for removing trace solvent from a material comprises rewetting the product with water during the drying process. Finished products such as suramin are produced efficiently to a high quality on a factory scale.

Abstract: Spent pyrophoric reaction catalyst from a reaction mixture is removed safely, cheaply, and rapidly using a single plate pressure filter. After hydrogenation, the reaction mixture is decanted, the desired hydrogenation product is removed, and catalyst-rich material which settles at the bottom of the vessel is delivered to a single plate pressure filter fitted with a filter bag 40 of permeable material. The spent catalyst is retained in the filter bag 40 and stored under water awaiting recovery. The filter apparatus 1 comprises a container having a domed base 2, a generally cylindrical sidewall 3 terminating in an upper rim 4 closed by a lid 5 having lifting lugs 6. The lid 5 is fixed in pressure-tight engagement with the sidewall 3 by flange engaging screw clamps 7 and an embedded polytetrafluoroethene gasket 8. The filter bag 40 is held in position by a band 11 and may be readily released for removal of the spent catalyst material. The bag 40 may be reused.

Abstract: A unit 1 for producing pyrogen controlled water on a small to medium factory scale comprises a number of charged ultrafiltration units 10 arranged in parallel. Orifice plates 15 are used to restrict and control the flow of deionized water to each filter 10. The filter units 10 are mounted on a frame 2 with a wheeled chassis 3 which may be pushed or moved by a forklift truck to a site where pyrogen controlled water is required. The unit 1 has an inlet line 4 for connection to a supply of deionized water and an outlet line 6 for connection to a user of pyrogen controlled water. The unit 1 may be purged with nitrogen from a supply 18. Sampling ports 17 in a common supply inlet 4 and a common outlet 6 ensure that the filtration efficiency can be closely monitored. The flow of water is monitored by a flowmeter 19 and pressure sensors 16 upstream of each filter facilitate a high level of control.

Abstract: A factory scale process for producing crystalline atorvastatin calcium includes the step of drying the isolated product in a vacuum pan dryer. The vacuum pan dryer has an agitator which is continuously rotated at a speed of approximately 1 rpm. High quality material is routinely and consistently produced with reduced cycle time.

Abstract: A factory scale process for producing crystalline atorvastatine trihydrate hemi calcium salt includes the addition of extra methyl tert-butyl ether to the reaction mixture to supersaturate the crystallization matrix. A seed slurry is made up in a make-up/delivery vessel and delivered, under pressure, to the reaction mixture. The process produces crystalline atorvastatin calcium within a consistent size range on a factory scale.

Abstract: A factory scale process for producing crystalline atorvastatin calcium includes the step of drying the isolated product in a vacuum pan dryer. The vacuum pan dryer has an agitator which is continuously rotated at a speed of approximately 1 rpm. High quality material is routinely and consistently produced with reduced cycle time.

Abstract: A unit 1 for producing pyrogen controlled water on a small to medium factory scale comprises a number of charged ultrafiltration units 10 arranged in parallel. Orifice plates 15 are used to restrict and control the flow of deionized water to each filter 10. The filter units 10 are mounted on a frame 2 with a wheeled chassis 3 which may be pushed or moved by a forklift truck to a site where pyrogen controlled water is required. The unit 1 has an inlet line 4 for connection to a supply of deionized water and an outlet line 6 for connection to a user of pyrogen controlled water. The unit 1 may be purged with nitrogen from a supply 18. Sampling ports 17 in a common supply inlet 4 and a common outlet 6 ensure that the filtration efficiency can be closely monitored. The flow of water is monitored by a flowmeter 19 and pressure sensors 16 upstream of each filter facilitate a high level of control.

Abstract: A batch process for carrying out a hydrogenation reaction comprises mixing a pyrophoric catalyst with reactants and solvents to form a reaction mixture in a reaction vessel. Hydrogen is added to the reaction vessel. After hydrogenation, the desired hydrogenation product is removed from the reaction vessel and the pyrophoric catalyst-rich material from the reaction vessel is delivered to a pressure filter. Water is added to the pyrophoric catalyst-rich material in the filter and the spent pyrophoric material is removed from the pressure filter in a water wet form.

Abstract: A factory scale process for producing crystalline atorvastatine trihydrate hemi calcium salt includes the addition of extra methyl tert-butyl ether to the reaction mixture to supersaturate the crystallization matrix. A seed slurry is made up in a make-up/delivery vessel and delivered, under pressure, to the reaction mixture. The process produces crystalline atorvastatin calcium within a consistent size range on a factory scale.

Abstract: An improved process for removing trace solvent from a material comprises rewetting the product with water during the drying process. Finished products such as suramin are produced efficiently to a high quality on a factory scale.

Abstract: A process for the preparation of 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl-4-chloro-4-deoxy-.alpha. -galactopyranoside comprising the steps of (a) reacting sucrose with a tritylating agent; (b) acetylating the tritylated reaction product; (c) detritylating the acetylated reaction product; (d) isomerizing the resulting penta-acetate; (e) chlorinating the isomerized product; and (f) deacetylating the chlorinated reaction product.