Patents by Inventor William W. Lai

William W. Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11957657
    Abstract: Disclosed are combination therapies including administration of I-DASH inhibitors and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: April 16, 2024
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, Wengen Wu
  • Patent number: 11925655
    Abstract: Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of “warhead” anthracycline or anthracycline derivative to FAP-expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compounds comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer undesirable fibrosis and undesirable inflammation.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: March 12, 2024
    Assignee: Bach Biosciences, LLC
    Inventors: William W. Bachovchin, Hung-sen Lai, David G. Sanford, Sarah E. Poplawski, Wengen Wu
  • Patent number: 9773621
    Abstract: An apparatus and method for the uniform dispersion of nano scaled redox particles in a conductive fiber including, combining at least one nano sized redox capable material having metal oxides and/or metals, at least one conductive binder, and at least one solvent to form electrically conductive metal imbedded fiber(s) by fiber spinning and the conductive polymeric binder having a molecular weight greater than 20,000 Daltons, and coating a substrate with the electrically conductive fiber(s) to form an active layer substrate complex having a conductivity greater than 0.05 S/cm.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: September 26, 2017
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca, John D. Stenger-Smith, Heather Meylemans
  • Patent number: 9670317
    Abstract: A material that can be used either as a standalone or coating additive that would both repel water and resist corrosion would greatly benefit the Navy. A method of making hydrophobic polymer, including combining a perylene derived monomer with a bisphenol derived monomer to produce a polymer mixture, and condensing said polymer mixture to produce a hydrophobic polymer.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 6, 2017
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Benjamin G. Harvey, Alfred J. Baca, Heather Meylemans
  • Patent number: 9666380
    Abstract: An apparatus and method for the uniform dispersion of nano scaled redox particles in a conductive fiber including, combining at least one nano sized redox capable material having metal oxides and/or metals, at least one conductive binder, and at least one solvent to form electrically conductive metal imbedded fiber(s) by fiber spinning and the conductive polymeric binder having a molecular weight greater than 20,000 Daltons, and coating a substrate with the electrically conductive fiber(s) to form an active layer/substrate complex having a conductivity greater than 0.05 S/cm.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: May 30, 2017
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca, John D. Stenger-Smith, Heather Meylemans
  • Patent number: 9627622
    Abstract: A method for making electronic devices based on derivatized ladder polymer (Pz-BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: April 18, 2017
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca
  • Patent number: 9558892
    Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: January 31, 2017
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Alfred J. Baca, William W. Lai
  • Patent number: 9435912
    Abstract: A wholly organic coating consisting of one or more layers of Py-BBL that is transparent in the IR region of the spectrum which is also thermally and oxdatively stable. This is coated onto IR transparent windows, domes and or optical lenses, for enhanced IR and signal filtering.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: September 6, 2016
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Lee R. Cambrea, Alfred J. Baca
  • Patent number: 9379328
    Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 28, 2016
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Alfred J. Baca, William W. Lai
  • Patent number: 9356240
    Abstract: A method for making electronic devices based on derivatized ladder polymer (Pz-BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: May 31, 2016
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca
  • Patent number: 9309440
    Abstract: A process used to cast films including; mixing Pyr-BBL and a room temperature molten salt from a range of about 35:65 weight ratio, dissolving the mixture in about 1% methanesulfonic acid to produce a Pyr-BBL solution, drop casting the solution onto glass or gold coated glass at 140° C. in air and heating for about 2 hours to produce films, drying the films in a vacuum oven at about 100° C. for at least 24 hours under dynamic vacuum, and rinsing the films to remove residual ionic liquid.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: April 12, 2016
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: John D Stenger-Smith, William W. Lai, David Irvin, Jennifer Irvin
  • Patent number: 9293267
    Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: March 22, 2016
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Alfred J Baca, William W Lai
  • Patent number: 9068043
    Abstract: A process used to cast films including; mixing Pyr-BBL and a room temperature molten salt from a range of about 35:65 weight ratio, dissolving the mixture in about 1% methanesulfonic acid to produce a Pyr-BBL solution, drop casting the solution onto glass or gold coated glass at 140° C. in air and heating for about 2 hours to produce films, drying the films in a vacuum oven at about 100° C. for at least 24 hours under dynamic vacuum, and rinsing the films to remove residual ionic liquid.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: June 30, 2015
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: John D Stenger-Smith, William W Lai, David Irvin, Jennifer Irvin
  • Patent number: 9048761
    Abstract: An energy harvesting device using auxetic materials includes a first auxetic conductive electrode layer. A second auxetic conductive electrode layer is associated with the first auxetic conductive electrode layer. The auxetic conductive electrode layers have negative Poisson ratios. At least one dielectric elastomer layer is associated in layered orientation between the first and second auxetic conductive electrode layers.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: June 2, 2015
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: M. Joseph Roberts, Alfred J. Baca, William W. Lai, Lawrence C. Baldwin, Michael T. Owens
  • Patent number: 9030079
    Abstract: An energy harvesting device using auxetic materials includes a first auxetic conductive electrode layer. A second auxetic conductive electrode layer is associated with the first auxetic conductive electrode layer. The auxetic conductive electrode layers have negative Poisson ratios. At least one dielectric elastomer layer is associated in layered orientation between the first and second auxetic conductive electrode layers.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: May 12, 2015
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: M. Joseph Roberts, Alfred J. Baca, William W. Lai, Lawrence C. Baldwin, Michael T. Owens
  • Patent number: 9017794
    Abstract: A plasmonic array and methods of fabricating having a substrate, a layer of elastomeric material cured in nanowell or nanopost features, a fluorescent layer, and a plasmonic metal layer on top.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: April 28, 2015
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Lee R. Cambrea, Alfred J. Baca
  • Patent number: 8993713
    Abstract: A n-type ladder copolymer including, a n-type ladder copolymer formed with alternating perylene and pyridine units having chemical structure A having two end groups, where perylene units having at least one solubilizing group attaching at position(s) 1, 6, 7, and/or 12, where R1, R2, R3, and R4 solubilizing group(s) are each independently selected from the group consisting of aryl, alkyl aryl, alkoxy aryl, and aryloxy aryl, and where n repeat units ranging from about 4 to about 400
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: March 31, 2015
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred Baca
  • Patent number: 8951828
    Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: February 10, 2015
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca
  • Patent number: 8692397
    Abstract: A mechanism for the conversion of vertical motion to translational or rotational motion includes a substrate, at least one permanent magnet, at least one coil of wire, at least one inelastic material, at least one elastic material, and at least one pivot point. The coil of wire is a solenoid.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: April 8, 2014
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca, M. Joseph Roberts, Lawrence C. Baldwin, Michael T. Owens
  • Patent number: 8692396
    Abstract: A hybrid system for harvesting magnetic and electrical energy includes a substrate, at least one permanent magnet, and at least one coil of wire equal in number to the permanent magnet. Each permanent magnet is configured to fit in the substrate. Each coil of wire is configured to fit circumferentially around a respective permanent magnet. Each coil of wire is configured to fit in the substrate.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: April 8, 2014
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: William W. Lai, Alfred J. Baca, M. Joseph Roberts, Lawrence C. Baldwin, Michael T. Owens