Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: A body for a skate boot includes a sole portion, a toe portion extending from a front end of the sole portion, two upper portions extending from two sides of the sole portion, and a heel portion extending from a rear end of the sole portion. The sole portion, toe portion, upper portions and heel portion are made of fiber laminations constructed by multiple layers of fiber fabrics and epoxy resin by means of hot-pressing in a die. At least one thermoplastic substratum is provided in the fiber laminations at the upper portions and heel portion, and has two sewn portions respectively formed at two distal ends at the upper portions and extending out from the fiber laminations inside the thermoplastic substratum. Thus, the body is light-weight, has good shock resistance, and can cover the user's foot well.

Abstract: A composite reinforced toecap for a shoe includes multiple composite fiber reinforcement layers and a larger fiber layer laminated between and extending out from the composite fiber reinforcement layers. The fiber layer is made of continuos-strands. The composite fiber reinforcement layers are made of fiber-reinforced-plastic composite materials, are laminated on the fiber layer to form a pre-product toecap. A bonding coating is applied to the fiber layer that extends beyond the composite fiber reinforcement layer to form a binding. The pre-product is cured and has a binding that can be sewn to the sole, upper or tongue of a shoe.