Patents by Inventor Wim DE MALSCHE
Wim DE MALSCHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11933710Abstract: A system for imaging particles in a fluid includes a substrate holder for holding a substrate comprising a channel or reservoir for containing the fluid in the substrate, a radiation source for providing irradiation in the substrate and a radiation detection unit for detecting particles in the fluid in the substrate. At least one of the radiation source and the radiation detection unit) are configured to obtain detection in one or more distinct detection sheets in the substrate. The system further comprises an actuator configured for imparting an oscillating mechanical movement of the substrate holder regarding the radiation detection unit and the radiation source, the oscillating mechanical movement being a movement comprising a movement component in a direction perpendicular to the plane wherein the one or more detection sheets are extending.Type: GrantFiled: April 17, 2019Date of Patent: March 19, 2024Assignee: VRIJE UNIVERSITEIT BRUSSELInventors: Wim De Malsche, Ozlem Sardan Sukas, Manly Callewaert, Pierre Gelin
-
Publication number: 20230330674Abstract: A method for producing a chemical reactor. The chemical reactor comprises one or more effective channels which comprise pillar structures, an input connected to one of the effective channels to allow fluid/gas into the effective channels and an output connected to one of the effective channels to remove at least one component of the liquid/gas. The method comprises obtaining an initial design of the reactor, further introducing into the initial design at least a structured area positioned adjacent to an effective channel of the one or more effective channels located at the edge of the initial design, the structured area not being fluidly connected to one of the effective channels, to obtain a further design and the production of the reactor according to the further design.Type: ApplicationFiled: June 19, 2023Publication date: October 19, 2023Inventors: Jeff OP DE BEECK, Paul JACOBS, Wim DE MALSCHE
-
Patent number: 11724259Abstract: A method for producing a chemical reactor, wherein the chemical reactor comprises one or more effective channels which comprise pillar structures, an input connected to one of the effective channels to allow fluid/gas into the effective channels and an output connected to one of the effective channels to remove at least one component of the liquid/gas. The method comprises obtaining an initial design of the reactor, further introducing into the initial design at least a structured area positioned adjacent to an effective channel of the one or more effective channels located at the edge of the initial design, the structured area not being fluidly connected to one of the effective channels, to obtain a further design and the production of the reactor according to the further design.Type: GrantFiled: June 30, 2017Date of Patent: August 15, 2023Assignee: PHARMAFLUIDICS nvInventors: Jeff Op De Beeck, Paul Jacobs, Wim De Malsche
-
Patent number: 11619587Abstract: A microfluidic device comprises a microfluidic channel having at least an inlet for receiving a fluid plug or an outlet for removing a fluid plug and a pillar based flow distributor for reorienting the fluid plug in such a way that the long axis of the fluid plug essentially is oriented perpendicular to the walls of the microfluidic channel, as opposed to its original orientation, in which the longer axis is oriented in the longitudinal direction of the narrower inlet channel. The width W of the microfluidic channel is substantially larger than the width w of the inlet or outlet channel. The microfluidic device is adapted for detecting a physical or chemical property of the fluid, the microfluidic device being configured for detecting the property in a detection area positioned across the microfluidic channel in a width direction of the microfluidic channel.Type: GrantFiled: April 27, 2018Date of Patent: April 4, 2023Assignee: PHARMAFLUIDICS NVInventors: Paul Jacobs, Wim De Malsche
-
Publication number: 20230056762Abstract: A fluidic device for processing a fluid or species therein is described. The device comprises a 3D channel including an inlet for receiving a sample fluid and an outlet for outputting the sample fluid. The channel is adapted for guiding flow of the sample fluid in an axial direction from the inlet to the outlet. The channel includes at least two side walls. The device also has a controllable flow inducer having electrodes for inducing, when the sample fluid is flowing through the channel, a motion of the sample fluid in the channel in a plane substantially orthogonal to the axial direction. Along at least one of the side walls at least part of the electrodes are formed by alternatingly at least an electrically conducting portion, an electrically insulating portion and a further electrically conducting portion.Type: ApplicationFiled: February 3, 2021Publication date: February 23, 2023Inventors: Wim DE MALSCHE, Eiko WESTERBEEK, Jan EIJKEL, Wouter OLTHUIS
-
Patent number: 11491458Abstract: A method for producing a chemical reactor device based on a fluid flow comprises obtaining a substrate with a fluid channel defined by a channel wall, in which an ordered set of silicon pillar structures is positioned in the fluid channel and electrochemically anodising at least the silicon pillar structures to make the silicon pillar structures porous at least to a certain depth. After the anodising, the substrate and pillar structures are thermally treated, the treatment being carried out at a temperature, with a duration and in an atmosphere such that any silicon oxide layer formed has a thickness of less than 20 nm. The substrate and the pillar structures are further functionalized.Type: GrantFiled: September 4, 2018Date of Patent: November 8, 2022Assignee: PHARMAFLUIDICS NVInventors: Wim De Malsche, Jeff Op De Beeck, Paul Jacobs, Bo Claerebout
-
Publication number: 20220048005Abstract: A chemical reactor is implemented on a substrate. The chemical reactor has multiple ducts for transporting a fluid and/or gas during use of the chemical reactor, in which the ducts optionally include pillar structures and at least one connection duct connected between two of the multiple ducts for transporting the fluid and/or gas from one duct to another. In the connection duct, a series of individual pillar structures are positioned behind each other in the longitudinal direction of the connection duct.Type: ApplicationFiled: December 20, 2019Publication date: February 17, 2022Inventors: Jeff OP DE BEECK, Bo CLAEREBOUT, Wim DE MALSCHE, Paul JACOBS
-
Publication number: 20210140869Abstract: A system for imaging particles in a fluid includes a substrate holder for holding a substrate comprising a channel or reservoir for containing the fluid in the substrate, a radiation source for providing irradiation in the substrate and a radiation detection unit for detecting particles in the fluid in the substrate. At least one of the radiation source and the radiation detection unit) are configured to obtain detection in one or more distinct detection sheets in the substrate. The system further comprises an actuator configured for imparting an oscillating mechanical movement of the substrate holder regarding the radiation detection unit and the radiation source, the oscillating mechanical movement being a movement comprising a movement component in a direction perpendicular to the plane wherein the one or more detection sheets are extending.Type: ApplicationFiled: April 17, 2019Publication date: May 13, 2021Inventors: Wim DE MALSCHE, Ozlem Sardan SUKAS, Manly CALLEWAERT, Pierre GELIN
-
Publication number: 20210072154Abstract: A microfluidic device comprises a microfluidic channel having at least an inlet for receiving a fluid plug or an outlet for removing a fluid plug and a pillar based flow distributor for reorienting the fluid plug in such a way that the long axis of the fluid plug essentially is oriented perpendicular to the walls of the microfluidic channel, as opposed to its original orientation, in which the longer axis is oriented in the longitudinal direction of the narrower inlet channel. The width W of the microfluidic channel is substantially larger than the width w of the inlet or outlet channel. The microfluidic device is adapted for detecting a physical or chemical property of the fluid, the microfluidic device being configured for detecting the property in a detection area positioned across the microfluidic channel in a width direction of the microfluidic channel.Type: ApplicationFiled: April 27, 2018Publication date: March 11, 2021Inventors: Paul JACOBS, Wim DE MALSCHE
-
Publication number: 20210023527Abstract: A method for producing a chemical reactor device based on a fluid flow comprises obtaining a substrate with a fluid channel defined by a channel wall, in which an ordered set of silicon pillar structures is positioned in the fluid channel and electrochemically anodising at least the silicon pillar structures to make the silicon pillar structures porous at least to a certain depth. After the anodising, the substrate and pillar structures are thermally treated, the treatment being carried out at a temperature, with a duration and in an atmosphere such that any silicon oxide layer formed has a thickness of less than 20 nm. The substrate and the pillar structures are further functionalized.Type: ApplicationFiled: September 4, 2018Publication date: January 28, 2021Inventors: Wim DE MALSCHE, Jeff OP DE BEECK, Paul JACOBS, Bo CLAEREBOUT
-
Publication number: 20200333299Abstract: A microfluidic device for analysing a specimen comprises a loading area for loading the specimen of interest and an analytical column. The loading area is connected on two sides to a first duct and a second duct respectively, both integrated in the microfluidic device. The microfluidic device comprises a first integrated input connected to the first duct to take the specimen into the loading area, a first integrated output connected to the second duct to discharge the rest of the specimen, once it has flown through the loading area, and a second integrated output downstream the analytical column. The first integrated output is arranged for during a first loading period of time being in circuit connected to the first integrated input so as to load the sample into the loading zone of the device while preventing loss of specimen during loading of the sample into the analytical column.Type: ApplicationFiled: June 30, 2020Publication date: October 22, 2020Inventors: Jeff OP DE BEECK, Paul JACOBS, Wim DE MALSCHE
-
Patent number: 10807054Abstract: A micro-reactor system for contacting fluids is described. The system comprises a first microfluidic channel structure for guiding a first fluid to at least one output nozzle thus generating a first sub-flow, a second microfluidic channel structure for guiding a second fluid to at least a second output nozzle thus generating a second sub-flow, said first output nozzle being aligned with said second output nozzle and arranged for contacting the first sub-flow and the second sub-flow. The micro-reactor comprises at least a third microfluidic channel structure for at least a third, inert, fluid generating at least a third sub-flow arranged to be positioned adjacent at least the first and/or the second sub-flows so as to act as a wall between said first and/or second sub-flows.Type: GrantFiled: June 22, 2015Date of Patent: October 20, 2020Assignee: VRUE UNIVERSITEIT BRUSSELInventors: Wim De Malsche, Tobias Vandermeersch
-
Patent number: 10794876Abstract: A chromatographic column assembly is described, comprising a channel and a flow inducer. The channel comprises an inlet for receiving a sample liquid and an outlet, and is adapted for separating the sample liquid into components when the sample liquid flows through the channel in an axial direction from the inlet to the outlet. The flow inducer is adapted for controllably inducing, when the sample fluid is flowing through the channel, a motion of the sample liquid in the channel in a plane substantially orthogonal to the axial direction.Type: GrantFiled: July 14, 2016Date of Patent: October 6, 2020Assignee: VRIJE UNIVERSITEIT BRUSSELInventor: Wim De Malsche
-
Patent number: 10697942Abstract: A microfluidic device for separating a phase in a specimen has been described. This is based on a microfluidic trapping area, channels connected to it and integrated inputs and outputs connected onto the channels. An additional integrated input is provided which allows the flow in the device to be controlled and which may prevent leaking of the specimen and the phase.Type: GrantFiled: July 12, 2016Date of Patent: June 30, 2020Assignee: PHARMAFLUIDICS NVInventors: Jeff Op De Beeck, Paul Jacobs, Wim De Malsche
-
Publication number: 20190314817Abstract: A method for producing a chemical reactor, wherein the chemical reactor comprises one or more effective channels which comprise pillar structures, an input connected to one of the effective channels to allow fluid/gas into the effective channels and an output connected to one of the effective channels to remove at least one component of the liquid/gas.Type: ApplicationFiled: June 30, 2017Publication date: October 17, 2019Inventors: Jeff OP DE BEECK, Paul JACOBS, Wim DE MALSCHE
-
Publication number: 20180202979Abstract: A microfluidic device for separating a phase in a specimen has been described. This is based on a microfluidic trapping area, channels connected to it and integrated inputs and outputs connected onto the channels. An additional integrated input is provided which allows the flow in the device to be controlled and which may prevent leaking of the specimen and the phase.Type: ApplicationFiled: July 12, 2016Publication date: July 19, 2018Inventors: Jeff OP DE BEECK, Paul JACOBS, Wim DE MALSCHE
-
Publication number: 20180202981Abstract: A chromatographic column assembly is described, comprising a channel and a flow inducer. The channel comprises an inlet for receiving a sample liquid and an outlet, and is adapted for separating the sample liquid into components when the sample liquid flows through the channel in an axial direction from the inlet to the outlet. The flow inducer is adapted for controllably inducing, when the sample fluid is flowing through the channel, a motion of the sample liquid in the channel in a plane substantially orthogonal to the axial direction.Type: ApplicationFiled: July 14, 2016Publication date: July 19, 2018Inventor: Wim DE MALSCHE
-
Publication number: 20170151537Abstract: A micro-reactor system for contacting fluids is described. The system comprises a first microfluidic channel structure for guiding a first fluid to at least one output nozzle thus generating a first sub-flow, a second microfluidic channel structure for guiding a second fluid to at least a second output nozzle thus generating a second sub-flow, said first output nozzle being aligned with said second output nozzle and arranged for contacting the first sub-flow and the second sub-flow. The micro-reactor comprises at least a third microfluidic channel structure for at least a third, inert, fluid generating at least a third sub-flow arranged to be positioned adjacent at least the first and/or the second sub-flows so as to act as a wall between said first and/or second sub-flows.Type: ApplicationFiled: June 22, 2015Publication date: June 1, 2017Inventors: Wim DE MALSCHE, Tobias VANDERMEERSCH
-
Publication number: 20160001199Abstract: A chemical reactor is described comprising a substrate with a fluid channel and a set of organized pillar structures positioned in the channel. The individual pillar structures have a length in the longitudinal direction of the channel and a width in the width direction of the channel whereby their width-to-length aspect ratio is at least 7.Type: ApplicationFiled: February 5, 2014Publication date: January 7, 2016Applicant: PHARMAFLUIDICS NVInventors: Wim DE MALSCHE, Gert DESMET, Jeff OP DE BEECK, Paul JACOBS