Patents by Inventor Wim Dehaen

Wim Dehaen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonate nucleosides useful in the treatment of viral diseases
    Patent number: 10167302
    Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, and their use in medicine particular as anti-viral agents; wherein: X is selected from O and NR11; Y is selected from O, S and NR12; A is selected from —(CR1R2)n-, —(CR9R10)—, —(CR9R10)—(CR1R2)n-, —(CR1R3)—(CR2R4)—(CR1R2)n-, —CR3?CR4—(CR1R2)n- and —C?C—(CR1R2)n-; R1 and R2 are independently selected from H, alkyl, hydroxyl, hydroxymethyl and halogen; R3 and R4 are independently selected from H and alkyl, or R3 and R4 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected from cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl and heteroaryl; R5 is selected from H, P(?O)(OH)2 and P(?O)(OH)—O—P(?O)(OH)2; R6 is selected from H and alkyl; R7 and R8 are independently selected from H, alkyl, halogen and hydroxymethyl R9 and R19 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: January 1, 2019
    Assignees: UNIVERSITY COLLEGE CORK, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Anita Maguire, Alan Ford, Jan Balzarini, Wim Dehaen
  • Phosphonucleosides useful in the treatment of viral disorders
    Patent number: 9822137
    Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein the groups are as defined in the claims. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for treating a viral disorder.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: November 21, 2017
    Assignees: UNIVERSITY COLLEGE CORK, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Wim Dehaen, Jan Balzarini, Anita Maguire, Sarah Jane Keane, Alan Ford, Nuala Maguire, Nicholas D. Mullins
  • PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES
    Publication number: 20170218001
    Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, and their use in medicine particular as anti-viral agents; wherein: X is selected from O and NR11; Y is selected from O, S and NR12; A is selected from —(CR1R2)n-, —(CR9R10)—, —(CR9R10)—(CR1R2)n-, —(CR1R3)—(CR2R4)—(CR1R2)n-, —CR3?CR4—(CR1R2)n- and —C?C—(CR1R2)n-; R1 and R2 are independently selected from H, alkyl, hydroxyl, hydroxymethyl and halogen; R3 and R4 are independently selected from H and alkyl, or R3 and R4 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected from cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl and heteroaryl; R5 is selected from H, P(?O)(OH)2 and P(?O)(OH)—O—P(?O)(OH)2; R6 is selected from H and alkyl; R7 and R8 are independently selected from H, alkyl, halogen and hydroxymethyl R9 and R19 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected
    Type: Application
    Filed: May 22, 2015
    Publication date: August 3, 2017
    Inventors: Anita MAGUIRE, Alan Ford, Jan BALZARINI, Wim DEHAEN
  • Anti-cancer compounds
    Patent number: 9278958
    Abstract: The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 8, 2016
    Assignees: Katholieke Universiteit Leuven K.U. Leuven R&D, Universita Degli Studi Di Ferrara
    Inventors: Jan Balzarini, Wim Dehaen, Joice Thomas, Sandra Liekens, Romeo Romagnoli, Pier Giovanni Baraldi
  • PHOSPHONUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISORDERS
    Publication number: 20150291640
    Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein the groups are as defined in the claims. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for treating a viral disorder.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 15, 2015
    Inventors: Wim Dehaen, Jan Balzarini, Anita Maguire, Sarah Jane Keane, Alan Ford, Nuala Maguire, Nicholas D. Mullins
  • NOVEL ANTI-CANCER COMPOUNDS
    Publication number: 20150126559
    Abstract: The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.
    Type: Application
    Filed: June 21, 2013
    Publication date: May 7, 2015
    Applicant: UNIVERSITA DEGLI STUDI DI FERRARA
    Inventors: Jan Balzarini, Wim Dehaen, Joice Thomas, Sandra Liekens, Romeo Romagnoli, Pier Giovanni Baraldi