Patents by Inventor Wim M. Degrave

Wim M. Degrave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallographic structure of TcPRACA and uses therefor
    Publication number: 20130143201
    Abstract: A method of identifying a substance that affects the biological activity of a Trypanosome cruzi proline racemase (TcPRAC) protein comprises providing a purified TcPRAC protein, providing a substance to be tested, combining the TcPRAC protein with the substance, and determining the effect of the substance on the biological activity of the TcPRAC protein.
    Type: Application
    Filed: July 17, 2009
    Publication date: June 6, 2013
    Inventors: Paola Minoprio, Pedro Alzari, Alejandro Buschiazzo, Christophe Grégoire, Armand Berneman, Wim M. Degrave
  • IDENTIFICATION AND CHARACTERIZATION OF RACEMASES, DEFINITION OF PROTEIN SIGNATURES, AND A TEST FOR DETECTING D-AMINO ACID AND FOR SCREENING MOLECULES CAPABLE OF INHIBITING THE ACTIVITY OF RACEMASE, ESPECIALLY PROLINE RACEMASE
    Publication number: 20120076815
    Abstract: This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 29, 2012
    Inventors: Paola Minoprio, Nathalie Chamond, Wim M. Degrave, Armand Berneman
  • Crystallographic structure of TcPRACA and uses therefor
    Patent number: 7585656
    Abstract: The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: September 8, 2009
    Assignees: Institute Pasteur, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Paola Minoprio, Pedro Alzari, Alejandro Buschiazzo, Christophe Grégoire, Armand Berneman, Wim M. Degrave
  • Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase
    Publication number: 20090162844
    Abstract: This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.
    Type: Application
    Filed: June 25, 2007
    Publication date: June 25, 2009
    Inventors: Paolo Minoprio, Nathalie Chamond, Wim M. Degrave, Armand Berneman
  • Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase
    Patent number: 7262015
    Abstract: This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: August 28, 2007
    Assignee: Institut Pasteur
    Inventors: Paolo Minoprio, Nathalie Chamond, Wim M. Degrave, Armand Berneman