Abstract: The present disclosure relates to an isolated antibody or antigen-binding fragment thereof that binds to human Sema3A. The isolated antibody or antigen-binding fragment according to the present disclosure i) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; ii) cross-reacts with mouse, cynomolgus, rat, pig and/or dog Sema3A, particularly wherein said isolated antibody or antigen-binding fragment thereof binds to mouse, cynomolgus, rat, pig and/or dog Sema3A with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; iii) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a binding activity as measured by surface plasmon resonance (SPR) of ?60%, ?70%, ?80%, or ?90%; iv) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro mesangial cell migration assay with an EC50 of ?10 nM, ?5 nM, ?2.

Abstract: Modified rubber compositions comprise by weight about 15-60% of a highly saturated aliphatic rubber such as ethylene-propylene-diene rubber, about 25-80% of acrylate monomer units; and less than about 5% multi-functional monomer units. The compositions exist as amorphous heterogeneously dispersed phases. The first phase comprises the copolymer rubber to which polymers of at least 10% of the other monomer units are grafted. The second phase comprises the other monomers polymerized as homo and copolymers, not grafted to the rubber. Optionally, up to 20% of the composition comprises high index monomer units. The high index monomer units may be copolymerized with the acrylate and grafted to the rubber. Greater than 10% of the monomer units other than rubber are grafted to the rubber. The number average molecular weight of the grafts is between 10,000 and 80,000 daltons.

Abstract: The invention relates to electrically conducting solid plastics, the conductivity of which is attributable to their containing finely divided particulate, conducting substances. The electrically conducting solid plastics are comprised of or contain a polymer such as polymethyl methacrylate having a discrete fine-particle structure, and the polymer particles of the polymer are "doped", at least on their surface, with at least one electrically conducting substance such as carbon black in an amount which establishes electrical conductivity. The conducting substance(s) are present in the form of a plurality of conducting particulate solid bodies, and wherein the condition is imposed that the glass temperature (Tg) of the polymer is not exceeded when the conducting substance is mixed with the polymer particles.

Abstract: This invention concerns transparent polymer mixtures that can be processed thermoplastically consisting of (A) polycarbonates, particularly Bisphenol A polycarbonates, and (B) copolymers of methyl methacrylate and 5 to 40 wt. % of N-substituted maleimides, with the substituent on the imide nitrogen being an optionally substituted cyclohexyl group, in which the copolymer (B) can also be made up of other .alpha.,.beta.-unsaturated monomer units in amounts of 0 to 40 wt. %.

Abstract: The invention relates to a method of manufacturing plastic, electrically conductive pressure-formed plates from thermoplastic plastic particles which are mechanically formed. In this method, mechanically formed, thermoplastic particles each particle having maximum particle diameter in the range of about 1 mm to about 10 mm in the middle of said particle, are mechanically mixed with an amount of at least one electric-current-conducting substance sufficient to provide electrical conductivity. The electric-current-conducting substance is furnished in the form of a plurality of particulate, electrically conducting solid bodies, said mixing being effected in the temperature region below the glass temperature (Tg) of the thermoplastic plastic material of which the thermoplastic particles are comprised. The mixture thus produced is compressed to form plastic pressure-formed plates by means of a pressure-forming device.

Abstract: The invention relates to a method of manufacturing plastic, electrically conductive pressure-formed plates from thermoplastic plastic particles which are mechanically formed. In this method, mechanically formed, thermoplastic particles, each particle having maximum particle diameter in the range of about 1 mm to about 10 mm in the middle of the particle, are mechanically mixed with an amount of at least one electric-current-conducting substance sufficient to provide electrical conductivity. The electric-current-conducting substance is furnished in the form of a plurality of particulate, electrically conducting solid bodies, said mixing being effected in the temperature region below the glass temperature (Tg) of the thermoplastic plastic material of which the thermoplastic particles are comprised. The mixture thus produced is compressed to form plastic pressure-formed plates by means of a pressure-forming device.

Abstract: A method for making thermostable methyl methacrylate/alpha-methylstyrene copolymers having a high heat distortion temperature and adaptable to use as molding compounds by emulsion polymerization of these monomers together with lower alkyl acrylates and/or styrene, the water phase being less than 70 weight percent of the total monomer/water components and the amount of emulsifier being less than 0.5 weight percent of the water component, the copolymer being isolated by freeze coagulation or extruder pinch-off.

Abstract: Transparent, thermoplastically processible polymer mixtures comprised of:(A) Polycarbonates, particularly bisphenol A polycarbonates; and(B) Copolymers of methyl methacrylate and monosubstituted (meth)acrylamides, the latter present in the amount of 5-25 wt. %, wherein the substituent on the amide nitrogen is a cyclic organic group having an aliphatic, aromatic, or heterocyclic structure, which has no appreciable absorption capability for visible light as far as the UV wavelength of 340 nm.

Abstract: A method of producing X-ray resist with etching patterns, using known supports which are coated with a film comprised of copolymers of methacrylonitrile and methacrylic acid is disclosed. This method uses the following protocol.(a) A copolymer of methacrylonitrile and methacrylic acid with molecular weight <700,000 is used for coating the support.(b) Before X-ray irradiation, the film is thermally treated at temperatures below 150.degree. C. until a solvent-free, uncrosslinked film is obtained.(c) After the X-ray irradiation, the film is tempered for 15-30 min at temperatures in the range 140.degree.-170.degree. C.(d) And subsequently the film is developed with a solvent system L comprised of water and/or an organic solvent which contains oxygen in the form of a hydroxyl group and/or an ether group and/or an ester group.

Abstract: A radiation sensitive polymeric material comprising a copolymer of methyl methacrylate and allyl methacrylate and at least one organosulfur compound having at least two --SH groups per molecule, said material being useful as a polymer resist sensitive to high energy radiation.

Abstract: Difficultly flammable polyarylene ether resins containing phosphorus having the structure ##STR1## and methods for making the same.

Abstract: What are disclosed are resinous polyarylene esters containing more than 1 percent by weight of phosphorus and having the formula--CO--A--CO--O--B--O.sub.n, wherein B is a bivalent aromatic group and A represents at least in part--phenylene--P(O).sub.x (R)--phenylene--,wherein R is lower alkyl or aryl and x is 0 or 1, the rest, if any, of A having the formula given for B, which esters have decomposition temperatures of at least 450.degree. C. and can be sintered or thermoplastically processed into sheets or other shapes having good self-extinguishing properties.

Abstract: What are disclosed are phosphorus-containing polyarylene esters,--O--A--O--CO--B--CO].sub.n,wherein A represents at least in part groups of the structure ##STR1## wherein x is 0 or 1 and R is aromatic or aliphatic, and wherein B represents either two different aromatic groups or at least one group with the structure --C.sub.6 H.sub.4 --R'--C.sub.6 H.sub.4 --, wherein R' is a bridging link of the group --O--, --S--, --SO.sub.2 --, --CO--, or isopropylidene, and wherein n is greater than 20, which esters have a phosphorus content of over 1 weight percent, are distinguished by improved thermoplastic processability, and are prepared by condensation of HO--A--OH, for example with ClCO--B--COCl in the presence of a base.

Abstract: What is disclosed are a method for making a transparent impact-resistant polymer comprising a rubbery phase of grafted polybutadiene and a hard copolymer phase, which polymer is adaptable to use as a molding material, which method comprises:(1) in a first polymerization stage, dissolving a solid polybutadiene rubber in a monomer mixture comprising (a) methyl methacrylate, (b) styrene, and (c) at least one of methyl acrylate or ethyl acrylate to give a solution containing from 3 to 10 percent by weight of said rubber, and then polymerizing the solution using an initiator promoting graft copolymerization and in the presence ab initio of a chain transfer agent until an amount of said monomer mixture which is one to two times the weight of said polybutadiene rubber introduced is converted, said monomers (a), (b), and (c) being present in said monomer mixture in a ratio by weight of (73.+-.5): (22.+-.2); (5.+-.

Abstract: What is disclosed is the polymerization of free radically-polymerizable compounds such as acryl compounds and methacryl compounds under the influence of light having a wave length from 200 nm to 500 nm in the presence of a symmetric azo compound comprising tertiary aliphatic hydrocarbon groups each having a molecular weight of 71 to 97 bound to the azo group, whereby the polymerization temperature can be maintained under 100.degree. C. by regulation of the light intensity.

Abstract: Symmetric azo-bis-mercapto compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are methyl or ethyl, R.sub.3 and R.sub.4 are the same or different alkylene having 1 to 4 carbon atoms, and n is 0 or 1, and a method for forming block copolymers of vinyl monomers in a two-step process employing such compounds as polymerization initiators.