Abstract: A wire bonding method and apparatus are provided for electronic components to enable PR processing and wire bonding to be carried out substantially concurrently. The apparatus comprises a bond head carrying a bonding tool for performing wire bonding and a rotary motor coupled to the bond head that is configured to change an angular orientation of the bonding tool relative to an electronic component to be bonded. There are first and second carriers for respectively mounting electronic components for wire bonding, and an optical system is arranged and configured to view bonding points on an electronic component mounted on the first carrier when the bonding tool is located over an electronic component mounted on the second carrier to perform wire bonding.

Abstract: A speaker assembly which includes a first diaphragm, a second diaphragm and a driver operationally positioned in an enclosure formed by the first diaphragm and the second diaphragm. The second diaphragm is made of a material composition which allows it to block sound energy, and reflect sound energy along to the first diaphragm.

Abstract: A flat panel speaker system is provided. The system includes, a modified panel having a front surface and a rear surface, wherein the modified panel acts as a diaphragm for the flat panel speaker system; a supporting member coupled to the rear surface of the modified panel; and a detachable driver operationally coupled to the supporting member.

Abstract: A vehicle seat for supporting a passenger of a vehicle. The seat includes a seat frame having a mount for mounting the frame to the vehicle, a support extending from the mount, a seat bottom mounted on the support for supporting the passenger when occupying the seat, and a seat back extending upward from the seat bottom. The seat back has a front surface oriented to face the passenger occupying the seat and a rear surface opposite the front surface. A video monitor is mounted on the seat frame, and a digital processor is operatively connected to the video monitor for processing a digital input for display as an image on the video monitor.

Abstract: The present invention includes nuclear fertility restorer genes, proteins encoded by those genes and transgenic plants and plant cells containing those genes. More particularly, the nuclear fertility restorer genes can be used to restore fertility in cytoplasmic male-sterile plants such as Brassica napus. Preferably, the nuclear fertility restorer genes are used with the Ogura (ogu) CMS system in Brassica napus.

Abstract: The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.

Abstract: The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

Abstract: A mist delivery system includes an enclosure having at least one misting nozzle coupled thereto. The enclosure includes a primary wall and a secondary wall, whereby an air channel is defined between the primary wall and the secondary wall. A controller directs misted air through the misting nozzle and further activates an air flow system such that misted air within the shower area flows through and is dried in the air channel.

Abstract: A rabbit skin containing biologically active substances is obtained by the process including vaccinating rabbit skin tissues with vaccinia virus, feeding a rabbit vaccinated with vaccinia virus, killing the rabbit when its skin tissues are sufficiently inflamed, and skinning the rabbit. The rabbit skin of the present invention can be used for preparing drugs and health foods.

Abstract: The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and/or efficacy can be determined.

Abstract: The present invention provides a combination dosing regimen for erythropoietin (EPO). More particularly, the present dosing regimen includes administration of at least a first dosing segment comprising a first exposure to EPO capable of stimulating the production of reticulocytes followed by a second exposure to EPO capable of sustaining the maturation of the reticulocytes into neocytes, and ultimately, red blood cells. Advantageously, the dosing segment may be cycled or repeated, any number of times and according to any desired time scheme, in order to provide or maintain any desired total red blood cell count and/or hemoglobin concentration. Methods of treatment employing the combination dosing regimen, as well as kits are also provided.

Abstract: The present invention refers to microcapsules with high permeability for low molecular weight molecules and no permeability for high molecular weight molecules encapsulating a nucleic acid amplification reaction mixture, in particular, a PCR reaction mixture and providing a compartment to perform a nucleic acid amplification, in particular, a PCR reaction and to applications of such capsules to perform parallel PCR, screening, construction of DNA libraries and sequencing.

Abstract: The present invention is directed to sustained-release pharmaceutical formulations of therapeutic proteins containing carboxymethyl ether cellulose polymer and methods of manufacture and use thereof.

Abstract: The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract: An interconnect switch stores data messages received from one or more source devices and prioritizes the data messages received from each source device based on the order that the data messages were received from the source device. For each available destination device associated with the interconnect switch, the interconnect switch identifies the data messages with the highest priority that are to be routed to the available destination device and selects one of the identified data messages for the available destination device. The interconnect switch then routes the selected data messages to the available destination devices.

Abstract: A cache management system in a multiprocessing computing system avoids blocking subsequent memory requests to access data in the cache after a previous memory request to access the data in the cache generates a cache miss and while the cache is being updated with the data. The previous memory request and subsequent memory requests are stored in a piggyback FIFO while the data is retrieved from a memory device. The cache is then updated with the data and the previous memory request and subsequent memory requests are processed on the cache.

Abstract: An apparatus for providing both a visual message and audio information simultaneously. The apparatus includes a display sign including an image or indicia thereon which provides visual information to an individual or a group of individuals being addressed by a user. The apparatus further includes a loud speaker and a lightweight, miniature microphone which is worn or carried by the user. The microphone provides an input signal to a microphone and amplifier module which drives the loud speaker. An optional volume control allows the volume of the audio signal generated by the loud speaker to be adjusted by the user. The apparatus forms a lightweight, easy to carry and convenient means for allowing a user to provide both visual and audio information simultaneously. The apparatus can easily be held with one or both hands of the user.

Abstract: A high fidelity sound system for a mobile platform is provided. The system includes a plurality of panels forming interior surfaces of a passenger cabin of the mobile platform. The system additionally includes a plurality of exciters. Various selected panels have at least one exciter is affixed thereto, wherein the exciters are adapted to resonate the panels to thereby generate sound waves. The system further includes a processing center that controls signals that drive the exciters. The signals are modified by the processing center so that each exciter generates sound waves within a specific frequency bandwidth that is based on the panel material or structure to which each exciter is affixed.

Abstract: Wedge wire bonding apparatus are disclosed with an improved configuration in which the transducer axis lies on a line that bisects the XY axes, and the operator views the bonding process by looking directly along the axis of the transducer. The result is a shorter bonding cycle time as time is saved as the bonding head moves from a first to a second bonding position while at the same time the operator is placed in the best possible position for viewing the bonding operation, which facilitates in particular any necessary alignment and set-up steps.