Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.

Abstract: A ring mechanism has pivoting hinge plates supported by a housing so pivoting of the hinge plates can open and close rings for holding the loose-leaf pages. The mechanism has an actuator including a lower arm for moving the hinge plates to open the rings and an upper arm for moving the hinge plates to close the rings. The upper arm has a hook thereon. An intermediate connector comprises a cross bar captured by the hook on the actuator. The intermediate connector connects a travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar in the housing. A locking element is moveable with the travel bar between a locking position and non-locking position.

Abstract: A ring mechanism has pivoting hinge plates supported by a housing so pivoting of the hinge plates can open and close rings for holding the loose-leaf pages. The mechanism has an actuator including a lower arm for moving the hinge plates to open the rings and an upper arm for moving the hinge plates to close the rings. The upper arm has a hook thereon. An intermediate connector comprises a cross bar captured by the hook on the actuator. The intermediate connector connects a travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar in the housing. A locking element is moveable with the travel bar between a locking position and non-locking position.

Abstract: A ring mechanism has pivoting hinge plates supported by a housing so pivoting of the hinge plates can open and close rings for holding the loose-leaf pages. The mechanism has an actuator including a lower arm for moving the hinge plates to open the rings and an upper arm for moving the hinge plates to close the rings. The upper arm has a hook thereon. An intermediate connector comprises a cross bar captured by the hook on the actuator. The intermediate connector connects a travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar in the housing. A locking element is moveable with the travel bar between a locking position and non-locking position.

Abstract: A ring mechanism has pivoting hinge plates supported by a housing so pivoting of the hinge plates can open and close rings for holding the loose-leaf pages. The mechanism has an actuator including a lower arm for moving the hinge plates to open the rings and an upper arm for moving the hinge plates to close the rings. The upper arm has a hook thereon. An intermediate connector comprises a cross bar captured by the hook on the actuator. The intermediate connector connects a travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar in the housing. A locking element is moveable with the travel bar between a locking position and non-locking position.

Abstract: A ring mechanism has pivoting hinge plates supported by a housing so pivoting of the hinge plates can open and close rings for holding the loose-leaf pages. The mechanism has an actuator including a lower arm for moving the hinge plates to open the rings and an upper arm for moving the hinge plates to close the rings. The upper arm has a hook thereon. An intermediate connector comprises a cross bar captured by the hook on the actuator. The intermediate connector connects a travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar in the housing. A locking element is moveable with the travel bar between a locking position and non-locking position.

Abstract: A ring mechanism has pivoting hinge plates supported by a housing so pivoting of the hinge plates can open and close rings for holding the loose-leaf pages. The mechanism has an actuator including a lower arm for moving the hinge plates to open the rings and an upper arm for moving the hinge plates to close the rings. The upper arm has a hook thereon. An intermediate connector comprises a cross bar captured by the hook on the actuator. The intermediate connector connects a travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar in the housing. A locking element is moveable with the travel bar between a locking position and non-locking position.

Abstract: A ring mechanism has housing supporting pivoting hinge plates. The mechanism has rings for holding loose-leaf pages. An actuator is mounted on the housing for causing pivoting motion of the hinge plates to open the rings. The mechanism includes a travel bar and intermediate connector connecting the travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar. The intermediate connector and travel bar are formed as one piece and have a living hinge adapted to allow the intermediate connector to pivot relative to the travel bar. The mechanism has a locking element moveable with the travel bar between a locking position and non-locking position. The living hinge is constructed to maintain a substantially constant spacing between the intermediate connector and the travel at points of connection of the living hinge to the intermediate connector and travel bar.

Abstract: A ring mechanism for retaining loose-leaf pages including a housing, hinge plates, and ring members mounted on the hinge plates for retaining pages on the mechanism. An actuating lever is pivotally mounted on the housing for engaging the hinge plates and pivoting them to selectively move the ring members between an open position and a closed position. A travel bar is operatively connected to the lever for selective movement between a position in which locking elements of the travel bar block the pivoting movement of the hinge plates and a position in which the travel bar allows the hinge plates to pivot. The lever is configured to deform when pivoting the hinge plates to close the ring members to delay movement of the travel bar and locking elements to the blocking position from the onset of pivoting motion of the hinge plates.

Abstract: A ring mechanism has housing supporting pivoting hinge plates. The mechanism has rings for holding loose-leaf pages. An actuator is mounted on the housing for causing pivoting motion of the hinge plates to open the rings. The mechanism includes a travel bar and intermediate connector connecting the travel bar to the actuator so movement of the actuator to pivot the hinge plates causes longitudinal movement of the travel bar. The intermediate connector and travel bar are formed as one piece and have a living hinge adapted to allow the intermediate connector to pivot relative to the travel bar. The mechanism has a locking element moveable with the travel bar between a locking position and non-locking position. The living hinge is constructed to maintain a substantially constant spacing between the intermediate connector and the travel at points of connection of the living hinge to the intermediate connector and travel bar.

Abstract: A ring mechanism for retaining loose leaf pages has a housing and hinge plates supported by the housing for pivoting motion relative to the housing. Ring members are mounted on the hinge plates and are moveable between a closed position and an open position. An actuator is mounted on the housing for movement relative to the housing for causing pivoting motion of the hinge plates. A locking element releasably locks the closed ring members in a locked position and releases the closed ring members to move to the open position in an unlocked position. An intermediate connector operably connects the locking element to the actuator. The intermediate connector is deformable during movement of the actuator.

Abstract: A ring binder mechanism includes a housing that supports two hinge plates for loose pivoting motion, moving the ring members apart or together. The mechanism also includes an actuating lever pivotally mounted on the housing. The lever moves a travel bar and its locking elements for controllably pivoting the hinge plates and the ring members mounted thereon between closed and open positions. In particular, the locking elements cam the hinge plates to softly close the ring members. When the ring members are apart, the locking elements register with openings in at least one of the hinge plates. When the ring members are together, the locking elements are substantially out of registration with the openings, blocking the hinge plates from pivoting to separate the ring members. The travel bar is formed with reinforcing structure to resist deforming the travel bar upon repeated operation.

Abstract: A ring mechanism for retaining loose-leaf pages comprises a housing, hinge plates, and ring members mounted on the hinge plates for retaining pages on the mechanism. An actuating lever is pivotally mounted on the housing for engaging the hinge plates and pivoting them to selectively move the ring members between an open position and a closed position. A travel bar is operatively connected to the lever for selective movement between a position in which locking elements of the travel bar block the pivoting movement of the hinge plates and a position in which the travel bar allows the hinge plates to pivot. The lever is configured to deform when pivoting the hinge plates to close the ring members to delay movement of the travel bar and locking elements to the blocking position from the onset of pivoting motion of the hinge plates.

Abstract: A ring mechanism for retaining loose-leaf pages comprises a housing, hinge plates, and ring members mounted on the hinge plates for retaining pages on the mechanism. An actuating lever is pivotally mounted on the housing for engaging the hinge plates and pivoting them to selectively move the ring members between an open position and a closed position. A travel bar is operatively connected to the lever for selective movement between a position in which locking elements of the travel bar block the pivoting movement of the hinge plates and a position in which the travel bar allows the hinge plates to pivot. The lever is configured to deform when pivoting the hinge plates to close the ring members to delay movement of the travel bar and locking elements to the blocking position from the onset of pivoting motion of the hinge plates.

Abstract: A ring binder mechanism comprises a housing, at least one ring for mounting loose leaf paper, and at least one mounting post extending outwardly from the housing. A base plate is adapted to be attached to a ring binder cover and has a surface adapted to receive the mounting post of the ring binder mechanism. A key can be received by the base plate into an affixing position with respect to the base plate and mounting post for securing the mounting post to the base plate.

Abstract: A ring mechanism for retaining loose-leaf pages comprises a housing, hinge plates, and ring members mounted on the hinge plates for retaining pages on the mechanism. An actuating lever is pivotally mounted on the housing for engaging the hinge plates and pivoting them to selectively move the ring members between an open position and a closed position. A travel bar is operatively connected to the lever for selective movement between a position in which locking elements of the travel bar block the pivoting movement of the hinge plates and a position in which the travel bar allows the hinge plates to pivot. The lever is configured to deform when pivoting the hinge plates to close the ring members to delay movement of the travel bar and locking elements to the blocking position from the onset of pivoting motion of the hinge plates.

Abstract: A ring mechanism for retaining loose leaf pages has a housing and hinge plates supported by the housing for pivoting motion relative to the housing. Ring members are mounted on the hinge plates and are moveable between a closed position and an open position. An actuator is mounted on the housing for movement relative to the housing for causing pivoting motion of the hinge plates. A locking element releasably locks the closed ring members in a locked position and releases the closed ring members to move to the open position in an unlocked position. An intermediate connector operably connects the locking element to the actuator. The intermediate connector is deformable during movement of the actuator.