Patents by Inventor Wolf-Dieter Engel

Wolf-Dieter Engel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative test for bacterial pathogens
    Patent number: 7718361
    Abstract: The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic acid, total DNA or total RNA, (ii) quantifying the amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen, and (iii) determining whether said amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen exceeds a first predetermined cut off value.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: May 18, 2010
    Assignees: Roche Molecular Systems, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ellen J. Baron, Wolf-Dieter Engel, Gerd Haberhausen, Peter Kaspar, Andreas M. Kogelnik
  • Process for DNA decontamination
    Publication number: 20070148035
    Abstract: A method and a disposable to avoid false nucleic acid amplification results based on the alklylation of DNA present at surfaces of disposables. More particularly, the present invention is directed to an improved method and a disposable, whereby the alkylation of DNA is performed using ethylene oxide.
    Type: Application
    Filed: November 29, 2006
    Publication date: June 28, 2007
    Inventors: Armin Tgetgel, Joachim Siedel, Alois Rainer, Wolf-Dieter Engel
  • Quantitative test for bacterial pathogens
    Publication number: 20060269914
    Abstract: The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic acid, total DNA or total RNA, (ii) quantifying the amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen, and (iii) determining whether said amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen exceeds a first predetermined cut off value.
    Type: Application
    Filed: December 5, 2003
    Publication date: November 30, 2006
    Inventors: Ellen Baron, Wolf-Dieter Engel, Gerd Haberhausen, Peter Kaspar, Andreas Kogelnik
  • Heat-labile desoxyribonuclease I variants
    Publication number: 20040248272
    Abstract: According to the invention, the desoxyribonuclease with increased thermolability is a variant, by way of amino acid substitution, of bovine pancreatic desoxyribonuclease I. The variant protein retains desoxyribonuclease activity. Moreover, the specific desoxyribonuclease activity of the variant of bovine pancreatic desoxyribonuclease I is approximately zero units per mg of protein following heating of the variant of bovine pancreatic desoxyribonuclease I for about 5 min at a temperature below 95° C. In addition, the variant of bovine pancreatic desoxyribonuclease I has no measurable ribonuclease activity.
    Type: Application
    Filed: December 19, 2003
    Publication date: December 9, 2004
    Inventors: Rainer Muller, Thomas Kirschbaum, Bernhard Suppmann, Helmut Schoen, Richard Engh, Artur Hoffmann, Johann-Peter Thalhofer, Joachim Siedel, Wolf-Dieter Engel
  • Process and reagent for the specific determination of LDL in serum samples
    Patent number: 5795786
    Abstract: A process and a reagent for the specific and direct determination of the LDL-fraction in the presence of other serum lipoproteins by adding a polymeric LDL-aggregating agent, followed by direct turbidimetric measurement of the LDL aggregate. Preferred are polymers which have a comb or brush type structure with the side groups having acid character, such as branched alkane sulfonic acids.
    Type: Grant
    Filed: August 6, 1996
    Date of Patent: August 18, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Wolf-Dieter Engel, Angelika Kurrle-Weittenhiller
  • Streptolysin O peptide antigens and methods for the determination of streptolysin antibodies
    Patent number: 5688659
    Abstract: SLO peptide antigens are described. These peptide antigens are suitable for the determination of SLO antibodies, as immunogens for the production of antibodies against SLO and as vaccines for the production of vaccines against SLO.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Christoph Seidel, Geoffrey Burns, Wolf-Dieter Engel
  • Streptolysin O peptide antigens and methods for the determination of streptolysin antibodies
    Patent number: 5445820
    Abstract: SLO peptide antigens are described. These peptide antigens are suitable for the determination of SLO antibodies, as immunogens for the production of antibodies against SLO.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: August 29, 1995
    Assignee: Boehringer Mannheim GmbH
    Inventors: Christoph Seidel, Geoffrey Burns, Wolf-Dieter Engel