Abstract: A tool for machining materials has a main part and one or more blades. The main part is made of a low-alloy steel. The socket is welded to the main part, and the blade edges are made of a hard metal. The hard metal contains at least 82 vol. % of tungsten carbide and a metallic binder made of a cobalt-nickel-based alloy. The hardness of the hard metal is greater than 1350 HV10. The socket has a sintered composite, and 40 vol. % to 60 vol. % of the composite is composed of a metal carbide and a metallic binder. At least 95 vol. % of the metallic binder is made of nickel, and the hardness of the composite is less than 800 HV10.

Abstract: A tool for machining materials has a main part and one or more blades. The main part is made of a low-alloy steel. The socket is welded to the main part, and the blade edges are made of a hard metal. The hard metal contains at least 82 vol. % of tungsten carbide and a metallic binder made of a cobalt-nickel-based alloy. The hardness of the hard metal is greater than 1350 HV10. The socket has a sintered composite, and 40 vol. % to 60 vol. % of the composite is composed of a metal carbide and a metallic binder. At least 95 vol. % of the metallic binder is made of nickel, and the hardness of the composite is less than 800 HV10.

Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signaling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signaling.

Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signalling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signalling.

Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signalling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signalling.

Abstract: The invention relates to a process for treating cast iron melts with silicon carbide. In this process, the silicon carbide used is subjected, before being introduced into the cast iron melt, to an oxidizing treatment in such a manner that the individual SiC granules are coated with a covering containing silica. A silicon carbide of this quality can be manufactured, for example, by subjecting the SiC in granular form, in a static or agitated mass, to an oxidizing atmosphere, such as air, oxygen or water vapor, at temperatures within the range of 900.degree.-1600.degree. C. and subsequently subjecting the agglomerates formed to gentle comminution to expose the SiC surfaces which, as a result of the formation of an agglomerate, completely or partially escaped the oxidizing attack.