Abstract: The present invention concerns the use of very high molecular weight hyaluronic acid (HMWHA) as a transporting vehicle for bioactive agents, such as ophthalmic drugs and other active pharmaceutical ingredients (API), with minimized side effects. An aspect of the invention includes an ophthalmic drug-delivery system (ODS) comprising HMWHA fluid and a bioactive agent, wherein the hyaluronic acid has an intrinsic viscosity of at least 2.5 m3/kg, and the HMWHA fluid is capable of transporting the bioactive agent into the eye; a method for delivering a bioactive agent into the eye; a method for treating, preventing, and/or delaying the onset or recurrence of an eye disorder in a human or animal subject; and a kit useful for carrying out the methods of the invention.

Abstract: The invention concerns a method for treating nerve damage or loss in the cornea of an eye (corneal nerve damage or loss) of a human or non-human animal subject, comprising topically administering a fluid comprising high molecular weight hyaluronic acid (HMWHA) to the ocular surface of the eye, wherein the hyaluronic acid has an intrinsic viscosity of at least 2.5 m3/kg.

Abstract: The present invention concerns ophthalmic compositions comprising a combination of hyaluronic acid (HA) as a vehicle, and one or more prostaglandin analogues, such as latanoprost, as an active pharmaceutical ingredient (API), wherein the HA acts as a transporting vehicle (transporter) of the prostaglandin analogue into the eye. The invention also includes methods for the use of such ophthalmic compositions for reduction of intraocular pressure to treat, prevent, and/or delay the onset or recurrence of ocular hypertension and glaucoma. The ophthalmic compositions of the invention have improved stability, improved API solubility, and improved efficacy in reducing intraocular pressure.

Abstract: The invention concerns a method for relieving idiopathic ocular pain by administering an effective amount of a fluid composition comprising hyaluronic acid, a hyaluronic acid analogue, or a combination thereof, to the eye of a human or non-human animal subject, wherein the fluid composition is administered after onset of the idiopathic ocular pain and in the absence of detectable signs known to cause ocular pain.

Abstract: The invention concerns a method for restoring or replenishing hyaluronic acid at an epithelial surface of a subject, comprising topically administering a composition to the epithelial surface of the subject, wherein the composition comprises high molecular weight hyaluronic acid, high molecular weight hyaluronic acid analogue, or a combination thereof, and wherein the epithelial surface has a deficiency in the amount or function of hyaluronic acid.

Abstract: The invention concerns a method for reducing, preventing, or delaying the onset of severe ocular surface disease, or preventing or delaying the progression of mild or moderate ocular surface disease to severe ocular surface disease, by topically administering a fluid comprising high molecular weight hyaluronic acid to the ocular surface of the eye of a human or non-human animal subject, wherein the hyaluronic acid has an intrinsic viscosity of >2.5 m3/kg and a concentration of <0.2% w/v.

Abstract: The invention concerns a method for reducing or delaying the onset of irritation, discomfort, inflammation (acute or chronic), and/or an immune response at the ocular surface by topically administering a fluid comprising high molecular weight hyaluronic acid to the ocular surface of the eye of a human or non-human animal subject, wherein the hyaluronic acid has an intrinsic viscosity of >2.5 m3/hg and a concentration of <0.2% w/v.

Abstract: Embodiments provide a method for determining sine or cosine correction values for an error compensation in an angle sensor. At least three pairs of values for at least three rotation angle values of an angle sensor are detected. Each pair of values includes a rotation angle value and an associated measurement signal value. The associated measurement signal value includes a sine component and a cosine component. The sine correction value for an offset error of the sine components of the measurement signal values is determined by adding the sine components of two detected measurement signal values. The cosine correction value for an offset error of the cosine components of the measurement signal values is determined by adding the cosine components of two detected measurement signal values. The sine correction value for the offset error of the sine components or the cosine correction value for the offset error of the cosine components is provided for error compensation.

Abstract: Embodiments provide a method for determining sine or cosine correction values for an error compensation in an angle sensor. At least three pairs of values for at least three rotation angle values of an angle sensor are detected. Each pair of values includes a rotation angle value and an associated measurement signal value. The associated measurement signal value includes a sine component and a cosine component. The sine correction value for an offset error of the sine components of the measurement signal values is determined by adding the sine components of two detected measurement signal values. The cosine correction value for an offset error of the cosine components of the measurement signal values is determined by adding the cosine components of two detected measurement signal values. The sine correction value for the offset error of the sine components or the cosine correction value for the offset error of the cosine components is provided for error compensation.

Abstract: A hot-beverage machine includes a water-storage tank, a heating device and a brewing chamber, which are connected to one another by a conduit system. A valve arrangement is disposed in a conduit segment of the conduit system and includes a gas-permeable membrane which includes a material made of PTFE and can be coated with a water-repellent coating.

Abstract: A mounting panel arrangement having a plurality of mounting panels for optoelectronic components. Two adjacent mounting panels (1, 2) are connected to one another, in a mechanically stable manner, a connection body (3). Each of the two mounting panels has a connection area (110, 210), each of which is associated with an attachment section (31, 32) of the connection body. For each connection area, a plug connection is formed between the connection area and the associated attachment section.

Abstract: A method for removal of CO2 from a gas stream by anti-sublimation, comprising the steps of: a) introducing a gas stream containing CO2 into a frosting vessel; b) reducing the temperature of at least a portion of the gas stream in said frosting vessel to a temperature at which solid CO2 is deposited by anti-sublimation; c) discharging the gas stream depleted of CO2 from the frosting vessel; and d) recovering the deposited solid CO2; wherein the pressure of the gas stream in step b) is higher than atmospheric pressure. An anti-sublimation system for removal of CO2 from a gas stream, comprising: a frosting vessel configured to receive the gas stream, said frosting vessel comprising a low temperature refrigeration device configured for reducing the temperature of at least a portion of a gas stream in said frosting vessel to a temperature at which solid CO2 is deposited by anti-sublimation; and a compressor configured to increase the gas pressure of the gas stream which is fed to the frosting vessel.

Abstract: A semiconductor lamp having a light-emitting semiconductor device, the semiconductor device comprising a carrier and at least one light-emitting semiconductor component on the carrier, and a heatsink. The heatsink has a first main face, the semiconductor device is located adjacent to the first main face, and the carrier faces the first main face. The semiconductor device is thermally coupled to the heatsink, and the heatsink has at least one feedthrough for electrical connection of the semiconductor device.

Abstract: The present invention relates to methods and systems for capture of CO2 from a gas stream by anti-sublimation, comprising the steps of evacuation of liquefied CO2 from a frosting vessel 1; evacuation of residual gases containing CO2 from the frosting vessel 1; and refrigeration of evacuated residual gases to a temperature at which liquid CO2 is formed.

Abstract: A method for removal of CO2 from a gas stream by anti-sublimation, comprising the steps of: a) introducing a gas stream containing CO2 into a frosting vessel; b) reducing the temperature of at least a portion of the gas stream in said frosting vessel to a temperature at which solid CO2 is deposited by anti-sublimation; c) discharging the gas stream depleted of CO2 from the frosting vessel; and d) recovering the deposited solid CO2; wherein the pressure of the gas stream in step b) is higher than atmospheric pressure. An anti-sublimation system for removal of CO2 from a gas stream, comprising: a frosting vessel configured to receive the gas stream, said frosting vessel comprising a low temperature refrigeration device configured for reducing the temperature of at least a portion of a gas stream in said frosting vessel to a temperature at which solid CO2 is deposited by anti-sublimation; and a compressor configured to increase the gas pressure of the gas stream which is fed to the frosting vessel.

Abstract: A mounting panel arrangement having a plurality of mounting panels for optoelectronic components. Two adjacent mounting panels (1, 2) are connected to one another, in a mechanically stable manner, a connection body (3). Each of the two mounting panels has a connection area (110, 210), each of which is associated with an attachment section (31, 32) of the connection body. For each connection area, a plug connection is formed between the connection area and the associated attachment section.

Abstract: A semiconductor lamp having a light-emitting semiconductor device, the semiconductor device comprising a carrier and at least one light-emitting semiconductor component on the carrier, and a heatsink. The heatsink has a first main face, the semiconductor device is located adjacent to the first main face, and the carrier faces the first main face. The semiconductor device is thermally coupled to the heatsink, and the heatsink has at least one feedthrough for electrical connection of the semiconductor device.

Abstract: A method and system for determining the position of a sound source in relation to a reference position, comprising the steps of generating a sound signal emitted from the sound source, detecting the emitted sound signal, processing the sound signal by the use of a physiological model of the ear, deducing at least one of lateral deviation in relation to the reference position, time delay of the sound signal from the sound source to the reference position, and the sound level of the detected sound signal.

Abstract: The invention relates to a method for carrying out the imaging processing of data sets of three-dimensional characters obtained from medical examination methods. According to the invention, a separation of the data of relevant anatomic structures as well as of other structures is carried out based on data provided in the form of volume elements. In addition, a spatial representation of at least one structure of interest ensues, and the individual objects of the structure of interest are separated from one another in such a manner that enables them to be repositioned in the spatial representation.