Patents by Inventor Wolfgang Maier-Borst
Wolfgang Maier-Borst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6812209Abstract: This invention relates to a conjugate which consists of an active substance and a native protein which is not regarded as exogenous and distinguish itself in that an intracellulary cleavable linker is present between the active substance and the protein. In addition, this invention concerns a process for the preparation of such a conjugate and its use.Type: GrantFiled: August 16, 2000Date of Patent: November 2, 2004Assignee: Deutsches Krebsforschungszentrum Stiftung des öffentlichen RechtsInventors: Hansjörg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Gerd Stehle, Andreas Wunder, Dirk Hoff-Biederbeck, Dieter Ludwig Heene
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Patent number: 6720304Abstract: The invention relates to conjugates comprising a D-enantiomer of a folic acid antagonist and a carrier. Furthermore, the invention relates to the production of such conjugates as well as their use.Type: GrantFiled: July 13, 2000Date of Patent: April 13, 2004Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen RechtsInventors: Hannsjörg Sinn, Hans-Herman Schrenk, Wolfgang Maier-Borst, Eva Frei, Gerd Stehle
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Patent number: 6706713Abstract: This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/or skin diseases.Type: GrantFiled: October 14, 1997Date of Patent: March 16, 2004Assignees: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Hansjörg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Gerd Stehle
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Patent number: 6410695Abstract: The present invention relates to a conjugate comprising an active substance and a compound having a binding site for metallic compounds. In addition, this invention relates to a process for the preparation of such a conjugate and its use.Type: GrantFiled: February 9, 1998Date of Patent: June 25, 2002Assignee: Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen RechtsInventors: Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle
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Patent number: 6395254Abstract: The present invention relates to conjugates, comprising an active substance, a polypeptide and a polyether, a process for the production of such conjugates as well as their use.Type: GrantFiled: May 4, 1999Date of Patent: May 28, 2002Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle, Heinz H. Fiebig
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Patent number: 6310352Abstract: The invention relates to a device for detecting input radiation such as X-rays, &ggr;-rays, ionizing radiation or fluorescent and low-level light. The device has at least one detection element comprising a sensor component (scintillator) for converting the input radiation into photons (scintillation light) in the UV, visible or IR part of the electromagnetic spectrum and an optical amplifier component which receives the light converted by the sensor component, forwards it for further processing and amplifies it at the same time. According to the invention, the amplifier component comprises at least one optical waveguide (1, 2, 2a, 2b, 20) whose material is optically pumped to amplify the scintillation light (3, 24, 25).Type: GrantFiled: March 26, 1999Date of Patent: October 30, 2001Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen RechtsInventors: Karlheinz Gross, Wolfgang Maier-Borst, Michael Klaus, Hans-Hermann Schrenk, Gerd Stehle, Hannsjörg Sinn
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Patent number: 6306367Abstract: The present invention relates to conjugates comprising a compound capable of emitting fluorescence, a linker and a protein. The present invention also concerns the preparation of such conjugates as well as their use.Type: GrantFiled: November 19, 1998Date of Patent: October 23, 2001Assignee: Deutsches Krebsforschungszentrum Stiftung des offentlichen RechtsInventors: Hansjörg Sinn, Wolfgang Maier-Borst, Gerd Stehle, Michael Kaus, Andreas Wunder, Hans-Hermann Schrenk
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Publication number: 20010012885Abstract: This invention relates to a conjugate which consists of an active substance and a native protein which is not regarded as exogenous and distinguishes itself in that an intracellularly cleavable linker is present between the active substance and the protein.Type: ApplicationFiled: April 4, 2001Publication date: August 9, 2001Applicant: Deutsches Krebsforschungszentrum stiftung des Offentlichen RechtsInventors: Hansjorg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Gerd Stehle, Andreas Wunder, Dirk Hoff-Biederbeck, Dieter Ludwig Heene
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Patent number: 6188748Abstract: A contour collimator has a plurality of plate-shaped diaphragm elements movably arranged with respect to each other in a guiding block to form a contour diaphragm for a radiation beam emitted by a radiation source towards the collimator, and at least one drive for moving the diaphragm elements. A drive is associated with each diaphragm element with the drives of a group of diaphragm elements being substantially adjacent, and a driving transmission arranged between each drive and the associated diaphragm element.Type: GrantFiled: May 15, 1998Date of Patent: February 13, 2001Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Otto Pastyr, Wolfgang Schlegel, Karl-Heinz Hover, Wolfgang Maier-Borst
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Patent number: 6177561Abstract: The present invention relates to a process for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. This invention also concerns a process for metalating compounds which can be bonded to a metal ion by reacting the compound with a metal ion in molten urea. Furthermore, the invention deals with the thus obtained products and their use for the therapy and/or diagnosis of tumors or inflammatory diseases.Type: GrantFiled: December 6, 1999Date of Patent: January 23, 2001Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle
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Patent number: 6150327Abstract: This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/or skin diseases.Type: GrantFiled: October 14, 1997Date of Patent: November 21, 2000Assignee: Deutsches Krebsforschungszentrum Stiftund des Offentlichen RechtsInventors: Hannsjorg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Gerd Stehle
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Patent number: 6147207Abstract: This invention relates to a process for the preparation of polyether-including chlorins and/or bacteriochlorins, comprising the following steps:(a) bonding a polyether to a porphyrin and(b) reacting the polyether-including porphyrin with a reducing agent.Furthermore, this invention concerns the polyether-including chlorins and bacteriochlorins, obtained by the process, as well as the use thereof for the photodynamic treatment of tumors.Type: GrantFiled: December 31, 1998Date of Patent: November 14, 2000Assignee: Deutsches Krebsforschungszentrum Stiftung des OffentlichenInventors: Hannsjorg Sinn, Hans-Hermann Schrenk, Michael Kaus, Wolfgang Maier-Borst, Gerd Stehle
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Patent number: 5906977Abstract: The present invention relates pharmaceutical compositions comprising a conjugate of an active substance, a linker and a carrier for the treatment and/or diagnosis of inflammatory diseases. The present invention further relates to methods using such pharmaceutical compositions for treating and diagnosing inflammatory diseases including, but not limited to, infectious diseases, autoimmune diseases, skin diseases, and inflammatory neovascularization.Type: GrantFiled: September 23, 1997Date of Patent: May 25, 1999Assignee: Deutsches Krebsforschungszentrum Stiftung des offentlichen RechtsInventors: Hansjorg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Gerd Stehle, Andreas Wunder, Dirk Hoff-Biederbeck, Dieter Ludwig Heene
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Patent number: 5622685Abstract: Tumor-active or tumor-diagnostic substances having preferred accumulation in the tumor, which are characterized in that they haveat least two phenolic hydroxyl and/or amino groups,at least one aliphatic amino group, orat least one phenolic hydroxyl and/or amino group andat least one aliphatic amino groupand that these groups are substituted with polyethylene glycol chains whose polymerization degree n is 5 to 250 and whose terminal hydroxyl group is substituted by C.sub.1 -C.sub.12 alkyl ester or ether, each of the substances being substituted by at least two such polyethylene glycol chains.Type: GrantFiled: June 7, 1995Date of Patent: April 22, 1997Assignee: Deutches Krebsforchunszentrum Stiftung des Offentlichen RechtsInventors: Hans J. Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Eckhard Friedrich, Georgi Graschew, Dieter Wohrle, Thomas Klenner
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Patent number: 5308604Abstract: The invention relates to conjugates composed ofa) at least one polyalcohol or a derivatized polyalcohol,b) at least one active agent,c) at least one linker andd) a protein,wherein the polyalcohol(s) or the derivatized polyalcohol(s) are polyalcohols or derivatized polyalcohols which are not recognized by the defense system of an organism as exogenous, and the protein is a protein which can be taken up by the tumor specifically or non-specifically, and is not recognized by the defense system of an organism as exogenous. These conjugates are suitable for, on the one hand, making possible a very sensitive method in nuclear medicine for the diagnosis of tumors and, on the other hand, for example also offering new methods for diagnosing tumors in X-ray diagnosis, computerized tomography, nuclear spin tomography, electron spin resonance spectroscopy or electron microscopy.Type: GrantFiled: March 26, 1992Date of Patent: May 3, 1994Assignee: Deutsches KrebsforschungsinstitutInventors: Hansjorg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Eckhard Friedrich, Georgi Graschew, Dieter Worhle
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Patent number: 4794629Abstract: A contour collimator has diaphragm plates arranged in displaceable fashion relative to one another. Each diaphragm plate is individually engageable with an adjustment element shared by all of the diaphragm plates for displacing one diaphragm plate relative to the remaining diaphragm plates. An interlock mechanism in engagement with the remaining diaphragm plates retains those plates in their respectively existing positions during displacement of the one plate. The adjustment element is displaceable from the one diaphragm plate to another diaphragm plate which can then be displaced by the adjustment element while the other plates are retained in position.Type: GrantFiled: May 14, 1987Date of Patent: December 27, 1988Assignee: Siemens AktiengesellschaftInventors: Otto Pastyr, Wolfgang Maier-Borst