Abstract: The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing cancer, preferably colorectal cancer, towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the expression level of at least SPON-2, and optionally determining the expression level of SPON-1, in said sample; c) comparing the expression level or expression levels determined in (b) with one or several reference expression levels; and d) predicting therapeutic success for said given mode of treatment in said patient or implementing therapeutic regimen in said subject from the outcome of the comparison in step (C).

Abstract: The present invention relates to uses of granulocyte colony stimulating factor (GCSF) or fragment thereof for the preparation of a pharmaceutical composition for treating organ dysfunction caused by ischemia, whereby the pharmaceutical composition is to be administered to a patient who is subjected to a surgical or interventional procedure in order to improve organ function, to improve organ function, to improve blood flow and/or to induce revascularization. Furthermore, the present invention relates to methods of treating organ dysfunction caused by ischemia comprising administering a therapeutically effective amount of G-CSF or fragment thereof to a patient who is subjected to a surgical or interventional procedure in order to improve organ function, to improve organ function, to improve blood flow and/or to induce revascularization.

Abstract: The invention relates to a method (i) for detecting a carcinoma, especially an adenocarcinoma, preferably a gastrointestinal carcinoma and more preferably a colorectal carcinoma, (ii) for predicting metastases, preferably liver metastases, depending on a primary colon carcinoma and/or (iii) for predicting the response of metastases to a 5-fluorouracil-containing chemotherapy. The inventive method comprises determining a gene expression profile of 120 marker genes or a selection thereof.

Abstract: Disclosed is a base module for a motion sensor, particularly a tacho generator, phase transducer, or transmission sensor for a motor vehicle. Said base module (22) comprises at least one busbar (11) for contacting an integrated circuit (36) used for sensing a motion. The base module (22) further comprises at least one wiring means (12, 14) which is arranged on the busbar (11). The busbar (11) and the wiring means (12) are surrounded at least in part by a sheath (26).

Abstract: A computer-implemented method and system for building a neural network is disclosed. The neural network predicts at least one target based upon predictor variables defined in a state space. First, an input data set is retrieved that includes the predictor variables and at least one target associated with the predictor variables for each observation. In the state space, a number of points is inserted in the state space based upon the values of the predictor variables. The number of points is less than the number of observations. A statistical measure is determined that describes a relationship between the observations and the inserted points. Weights and activation functions of the neural network are determined using the statistical measure.

Abstract: A computer-implemented method and system for building a neural network is disclosed. The neural network predicts at least one target based upon predictor variables defined in a state space. First, an input data set is retrieved that includes the predictor variables and at least one target associated with the predictor variables for each observation. In the state space, a number of points is inserted in the state space based upon the values of the predictor variables. The number of points is less than the number of observations. A statistical measure is determined that describes a relationship between the observations and the inserted points. Weights and activation functions of the neural network are determined using the statistical measure.

Abstract: Methods and/or devices for detecting the flow rate of a flowing medium, in particular the flow rate of a flowing air mass, are described, in which the flowing medium is detected with two evaluation methods that operate according to different principles and the two measurement signals obtained are set in relation to each other in order to determine correction methods. Since the two measurement methods react differently to interference effects, the comparison of the two output signals permits conclusions to be drawn as to the type and the order of magnitude of the interference effects and a corrected measurement signal can be obtained, which is independent of the interference effects.

Abstract: A computer-implemented method and system for building a neural network is disclosed. The neural network predicts at least one target based upon predictor variables defined in a state space. First, an input data set is retrieved that includes the predictor variables and at least one target associated with the predictor variables for each observation. In the state space, a number of points is inserted in the state space based upon the values of the predictor variables. The number of points is less than the number of observations. A statistical measure is determined that describes a relationship between the observations and the inserted points. Weights and activation functions of the neural network are determined using the statistical measure.

Abstract: A vibration sensor for direct or indirect mounting on a vibrating component has a housing, a pressure sleeve having a central bore and a piezoelectric disk situated between two insulator disks and two contact disks, a seismic mass acting on the disks by way of a spring element. The spring element is designed with a ring shape and has a projection on its inside ring area. On the outside circumference of the pressure sleeve there is a recess which is designed to correspond to the projection and is formed to accommodate the projection on the spring element.

Abstract: A vibration sensor for direct or indirect mounting on a vibrating component such as an engine block. The vibration sensor has a housing and a pressure sleeve, which includes a central bore, a cylindrical area and a flange-like edge. A piezoelectric disk is situated between two contact disks. A seismic mass acts on piezoelectric disk by way of a spring element and a threaded ring. Insulating disks are situated on the sides of the contact disks facing away from the piezoelectric disk. The insulating disks have an inside diameter that is less than an outside diameter of the cylindrical area of the pressure sleeve.

Abstract: A vibration pickup has a pressure sleeve which is placeable on a component causing vibrations, a sensor element which detects the vibration, a seismic mass which is placeable outside of the sleeve on a support surface of the sensor element with an axial pretensioning, so that the sensor element is held between the seismic mass and a flange-like segment of the pressure sleeve, the seismic mass and the pressure sleeve being formed as a one-piece integral component.

Abstract: Methods and/or devices for detecting the flow rate of a flowing medium, in particular the flow rate of a flowing air mass, are described, in which the flowing medium is detected with two evaluation methods that operate according to different principles and the two measurement signals obtained are set in relation to each other in order to determine correction methods. Since the two measurement methods react differently to interference effects, the comparison of the two output signals permits conclusions to be drawn as to the type and the order of magnitude of the interference effects and a corrected measurement signal can be obtained, which is independent of the interference effects.

Abstract: A vibration sensor (1) is provided for direct or indirect mounting on a vibrating component such as an engine block. The vibration sensor has a housing (10) and a pressure sleeve (2), which includes a central bore (14), a cylindrical area (12) and a flange-like edge (13). A piezoelectric disk (3) is situated between two contact disks (7). A seismic mass (4) acts on piezoelectric disk (3) by way of a spring element (5) and a threaded ring (6). Insulating disks (8) are situated on the sides of the contact disks (7) facing away from the piezoelectric disk (3). The insulating disks (8) have an inside diameter (D1) that is less than an outside diameter (D2) of the cylindrical area (12) of the pressure sleeve (2).

Abstract: A vibration sensor for direct or indirect mounting on a vibrating component has a housing, a pressure sleeve (3) having a central bore (14) and a piezoelectric disk (4) situated between two insulator disks (12) and two contact disks (9), ca seismic mass (5) acting on the disks by way of a spring element (6). The spring element (6) is designed with a ring shape and has a projection (17) on its inside ring area. On the outside circumference of the pressure sleeve (3) there is a recess (15) which is designed to correspond to the projection (17) and is formed to accommodate the projection (17) on the spring element (6).

Abstract: A computer-implemented method and system for building a neural network is disclosed. The neural network predicts at least one target based upon predictor variables defined in a state space. First, an input data set is retrieved that includes the predictor variables and at least one target associated with the predictor variables for each observation. In the state space, a number of points is inserted in the state space based upon the values of the predictor variables. The number of points is less than the number of observations. A statistical measure is determined that describes a relationship between the observations and the inserted points. Weights and activation functions of the neural network are determined using the statistical measure.

Abstract: A vibration pickup has a pressure sleeve which is placeable on a component causing vibrations, a sensor element which detects the vibration, a seismic mass which is placeable outside of the sleeve on a support surface of the sensor element with an axial pretensioning, so that the sensor element is held between the seismic mass and a flange-like segment of the pressure sleeve, the seismic mass and the pressure sleeve being formed as a one-piece integral component.

Abstract: The invention concerns an in vitro test procedure for the detection of chemically induced effects on embryonic development and for differentiation for the purpose of embryotoxicity/teratogenicity screening based on differentiated pluripotent embryonic stem (ES) cells from mice and rats using embryonic germ (EG) cells obtained from primoridial germ cells. The proposed test procedure is characterised in that stable transgenic ES or EG cell clones containing tissue-specific promoters and reporter genes are selected, differentiation-dependent expression of tissue-specific genes is carried out following differentiation of ES cells in the presence of embryotoxic substances acting at specific times into different germination path derivatives; this is followed by detection of chemically induced activation, repression or modulation of tissue-specific genes which regulate embryonic development.

Abstract: The invention concerns embryonal (cardiomyocytary and cardiomyoblastary) cardiac muscle cells, their preparation and their use, in particular for cell-mediated gene transplant. The areas of application of the invention are medicine and genetic engineering. The embryonal cardiac muscle cells according to the invention contain two gene constructs comprising: a) a regulatory, 1.2-kb long DNA sequence of the ventricle-specific myosin light-chain-2 (MLC-2v) promoter, the selectable marker gene .beta.-galactosidase in fusion with the reporter gene neomycin; and b) a regulatory DNA sequence of the herpes simplex virus thymidine kinase promoter and the selectable marker gene hygromycin, and optionally immortalizing genes and/or optionally genes inactivated by homologous recombination and/or optionally one or a plurality of therapeutic genes.

Abstract: A transfer press or similar press installation is provided with a press frame including press supports, a press bed, and headpieces, these press parts being rigidly connected with one another by turnbuckles. The press installation includes slides and a transfer device, which are movable by driving devices. Longitudinal traverses are provided which extend along the length of at least the working stages. The press supports are arranged in front of and behind the working stages, and the longitudinal traverses are placed on these press supports. The longitudinal traverses are provided with guides which interact with guides mounted on the slides for the bearing of the slides which move up and down. As a result, a stable and cost-effective construction of the press installation is achieved while supports in the central working areas are omitted.

Abstract: A multistand press or similar press facility for the forming of sheet metal parts, is provided with bedplate, press stand and several press slides driven by the press drive for tool top parts interacting with tool bottom parts. Gearings for deflecting the rotating movement of the motor drive into the upward and downward movement of the press slides are arranged between press stands which each form a pair of stands, and are disposed opposite one another, and above the introduction of force into the press slides. Two gearings are provided for the respective pair of stands of two press slides. This make it possible to drive the press slides assigned to a pair of press stands from one press stand area.