Patents by Inventor Wolfgang Raether

Wolfgang Raether has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5188832
    Abstract: A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the endo- or ectoparasites.
    Type: Grant
    Filed: February 14, 1990
    Date of Patent: February 23, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz Mehlhorn, Horst Taraschewski, Gunter Schmahl, Wolfgang Raether, Manfred Rosner
  • Patent number: 5158888
    Abstract: Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: October 27, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Peter Hammann, Susanne Grabley, Hartmut Voelskow, Burkhard Sachse, Wolfgang Raether, Carlo Giani, Gerhard Seibert
  • Patent number: 5100921
    Abstract: New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: March 31, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck
  • Patent number: 5100890
    Abstract: Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a--(CH.sub.2).sub.2-11 chain or a bridged--(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomes are resolved.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: March 31, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Siegel, Klaus-Dieter Kampe, Hans-Georg Alpermann, Hermann J. Gerhards, Patricia Usinger, Ulrich Schacht, Margret Leven, Wolfgang Raether, Walter Dittmar, Burkhard Sachse
  • Patent number: 5023357
    Abstract: Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 l and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a --(CH.sub.2).sub.2-11 chain or a bridged --(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III 0=CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.
    Type: Grant
    Filed: September 21, 1989
    Date of Patent: June 11, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Siegel, Klaus-Dieter Kampe, Hans-Georg Alpermann, Hermann J. Gerhards, Patricia Usinger, Ulrich Schacht, Margret Leven, Wolfgang Raether, Walter Dittmar, Burkhard Sachse
  • Patent number: 4945108
    Abstract: New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: July 31, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck
  • Patent number: 4914216
    Abstract: Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: April 3, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Peter Hammann, Susanne Grabley, Hartmut Voelskow, Burkhard Sachse, Wolfgang Raether, Carlo Giani, Gerhard Seibert
  • Patent number: 4877878
    Abstract: Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R.sup.1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N-R.sup.3 ; R.sup.2 =alkyl, alkoxy, halogen, SCH.sub.3, COC.sub.6 H.sub.5, CF.sub.3, COOCH.sub.3, COOC.sub.2 H.sub.5, or NO.sub.2 ; n=0-2; R.sup.2, under certain circumstances, is alternatively --CH.dbd.CH--CH.dbd.CH-- or phenoxy are described. Processes for the preparation thereof are also described. ##STR2## are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.
    Type: Grant
    Filed: December 29, 1988
    Date of Patent: October 31, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Dieter Kampe, Wolfgang Raether, Walter Dittmar
  • Patent number: 4876354
    Abstract: Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a --(CH.sub.2).sub.2-11 chain or a bridged --(CH.sub.2).sub.4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.
    Type: Grant
    Filed: May 3, 1988
    Date of Patent: October 24, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Siegel, Klaus-Dieter Kampe, Hans G. Alpermann, Hermann J. Gerhards, Patricia Usinger, Ulrich Schacht, Margret Leven, Wolfgang Raether, Walter Dittmar, Burkhard Sachse
  • Patent number: 4873347
    Abstract: It is possible to prepare the demalonyl compound of macrolide lactones by hydrolysis in the presence of a base without a retro-aldol cleavage occurring.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: October 10, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Peter Hammann, Susanne Grabley, Wolfgang Raether, Bernd Ciommer, Heinz Kluge, Burkhard Sachse
  • Patent number: 4870088
    Abstract: Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides.They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent).The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: September 26, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ernst Blume, Wolfgang Schaper, Heinz Ehrhardt, Wolfgang Raether, Walter Dittmar, Heinz Hanel, Burkhard Sachse
  • Patent number: 4861758
    Abstract: Coccidiocidal compositions which contain the polyether antibiotic maduramicin or its salt in combination with one or more active substances from the group comprising meticlorpindol methyl benzoquate, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Wolfgang Raether
  • Patent number: 4859670
    Abstract: Compounds of the formula I ##STR1## in which A equals CH or N, Ar equals phenyl, naphthyl or thienyl, R.sup.1 equals alkyl or halogen, and Y is a number of nitrogen-containing heterocyclic rings, have an excellent antimycotic action.The compounds IIIa ##STR2## are valuable intermediates for the preparation thereof.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: August 22, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Dieter Kampe, Wolfgang Raether, Walter Dittmar, Heinz Hanel
  • Patent number: 4855299
    Abstract: Coccidiocidal agents which contain the polyether antibiotic monensin or its salt in combination with one or more active substances from the group comprising methyl benzoquate, nicarbazin, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: August 8, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Wolfgang Raether
  • Patent number: 4829075
    Abstract: Compounds I ##STR1## where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, fluorenyl, thienyl, furyl, pyridyl, isoxazolyl, pyrazolyl, benzofuryl or benzothienyl,Z equals CO, CH.sub.2 or radicals of ketone derivatives;Y equals azole or equals --X--R.sup.8 (R.sup.8 =(cyclo)alkyl or an aromatic) or equals a number of amine derivatives or equal acyl,are antimycotics. The preparation and use as medicaments are described.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: May 9, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz Ehrhardt, Ernst Blume, Wolfgang Raether, Walter Dittmar
  • Patent number: 4824846
    Abstract: Compounds I ##STR1## where A equals CH or N; Ar equals naphthyl, thienyl or phenyl; R.sup.1 equals alkyl, F or Cl; g equals zero, 1 or 2; and Y equals various heterocyclic bases, and the acid-addition salts thereof, are described.Several preparation processes are described.The compounds IIIa ##STR2## where R.sup.1, g and Y are as specified in the case of the formula I, serve as intermediates for the preparation of these compounds. Processes are also specified for the preparation of IIIa.I represent valuable antimycotics.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: April 25, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus D. Kampe, Wolfgang Raether, Walter Dittmar, Heinz Hanel
  • Patent number: 4824847
    Abstract: Coccidiocidal compositions which contain the polyether antibiotic lasalocid A or its salt or ester in combination with one or more active substances from the group comprising meticlorpindol, methyl benzoquate, nicarbazin, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: April 25, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Wolfgang Raether
  • Patent number: 4818758
    Abstract: Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R.sup.1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N--R.sup.3 ; R.sup.2 =alkyl, alkoxy, halogen, SCH.sub.3, COC.sub.6 H.sub.5, CF.sub.3, COOCH.sub.3, COOC.sub.2 H.sub.5, or NO.sub.2 ; n=0-2; R.sup.2, under certain circumstances, is alternatively --CH.dbd.CH--CH.dbd.CH-- or phenoxy are described. Processes for the preparation thereof are also described.Compounds IIIa ##STR2## are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: April 4, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Dieter Kampe, Wolfgang Raether, Walter Dittmar
  • Patent number: 4808606
    Abstract: Alkenylazoles of formula I a/b ##STR1## in which X/Y is H, alkyl, phenyl, Hal, alkoxy or alkylthio; Z is CH or N; R is alkyl or a bridged (CH.sub.2).sub.m chain; and A is alkylene or a bridged alkylene chain; and the salts of these alkenylazoles are antimycotic agents or fungicides.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: February 28, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Siegel, Wolfgang Raether, Walter Dittmar
  • Patent number: 4797409
    Abstract: New 1-hydroxy-2-pyridones of the general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R.sup.1 and R.sup.3 preferably being hydrogen, and R.sup.2 preferably being methyl,X denotes S or, preferably, O,Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine,Z denotes a single bond or the bivalent radicals O, S, --CR.sub.2 -- (R=H or C.sub.1 -C.sub.4 -alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C.sub.1 -C.sub.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: January 10, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Lohaus, Walter Dittmar, Heinz Hanel, Wolfgang Raether, Dieter Reuschling, Bengt-Thomas Grobel