Patents by Inventor Wolfgang Stenzel
Wolfgang Stenzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040242633Abstract: The present invention relates to a &bgr;3 adrenergic receptor agonist of formula I: 1Type: ApplicationFiled: May 4, 2004Publication date: December 2, 2004Inventors: Britta Evers, Cynthia Darshini Jesudason, Rushad Eruch Karanjawala, David Michael Remick, Gerd Ruehter, Daniel Jon Sall, Theo Schotten, Miles Goodman Siegel, Wolfgang Stenzel, Russell Dean Stucky, John Arnold Werner
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Patent number: 6730792Abstract: The present invention relates to a &bgr;3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obesity. The compound can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compound can be used to reduced neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.Type: GrantFiled: December 13, 2002Date of Patent: May 4, 2004Assignee: Eli Lilly and CompanyInventors: Britta Evers, Cynthia Darshini Jesudason, Rushad Eruch Karanjawala, David Michael Remick, Daniel Jon Sall, Miles Goodman Siegel, Wolfgang Stenzel, Russell Dean Stucky, John Arnold Werner
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Patent number: 6693109Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: GrantFiled: January 29, 2003Date of Patent: February 17, 2004Assignees: Eli Lilly and Company, Millennium Pharmaceuticals, Inc.Inventors: Matthew J. Fisher, Joseph A. Jakubowski, John J. Masters, Jeffrey T. Mullaney, Michael Paal, Gerd Ruhter, Kenneth J. Ruterbories, Robert M. Scarborough, Theo Schotten, Wolfgang Stenzel
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Publication number: 20030191156Abstract: The present invention relates to a &bgr;3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obesity. The compound can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compound can be used to reduced neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.Type: ApplicationFiled: December 13, 2002Publication date: October 9, 2003Inventors: Britta Evers, Cynthia Darshini Jesudason, Rushad Eruch Karanjawala, David Michael Remick, Daniel Jon Sall, Miles Goodman Siegel, Wolfgang Stenzel, Russell Dean Stucky, John Arnold Werner
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Publication number: 20030171373Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: ApplicationFiled: January 29, 2003Publication date: September 11, 2003Inventors: Matthew J. Fisher, Joseph A. Jakubowski, John J. Masters, Jeffrey T. Mullaney, Michael Paal, Gerd Ruhter, Kenneth J. Ruterbories, Robert M. Scarborough, Theo Schotten, Wolfgang Stenzel
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Publication number: 20030130342Abstract: This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: ApplicationFiled: September 9, 2002Publication date: July 10, 2003Inventors: Matthew J. Fisher, Anne Marie Happ, Joseph A. Jakubowski, Michael Dean Kinnick, Allen D. Kline, Michael John Martinelli, John Michael Morin, Michael Paal, Gerd Ruhter, Kenneth James Ruterbories, Daniel J. Sall, Theo Schotten, Marshall A. Skelton, Wolfgang Stenzel, Robert Theodore Vasileff
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Patent number: 6528534Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: GrantFiled: July 6, 2001Date of Patent: March 4, 2003Assignees: Millennium Pharmaceuticals, Inc., Eli Lilly and CompanyInventors: Matthew J. Fisher, Joseph A. Jakubowski, John J. Masters, Jeffrey T. Mullaney, Kenneth J. Ruterbories, Michael Paal, Gerd Ruhter, Theo Schotten, Wolfgang Stenzel, Robert M. Scarborough
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Patent number: 6448269Abstract: This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: GrantFiled: June 18, 2001Date of Patent: September 10, 2002Assignee: Eli Lilly and CompanyInventors: Matthew J. Fisher, Anne Marie Happ, Joseph A. Jakubowski, Michael Dean Kinnick, Allen D. Kline, Michael John Martinelli, John Michael Morin, Jr., Michael Paal, Gerd Rühter, Kenneth James Ruterbories, Daniel J. Sall, Theo Schotten, Marshall A. Skelton, Wolfgang Stenzel, Robert Theodore Vasileff
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Patent number: 6410562Abstract: This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present, to pharmaceutical compositions comprising them, and to processes for their preparation.Type: GrantFiled: December 8, 2000Date of Patent: June 25, 2002Assignee: Eli Lilly and CompanyInventors: Michael R. Jirousek, Michael Paal, Gerd Ruhter, Theo Schotten, Kumiko Takeuchi, Wolfgang Stenzel
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Publication number: 20020013325Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: ApplicationFiled: July 6, 2001Publication date: January 31, 2002Inventors: Matthew J. Fisher, Joseph A. Jakubowski, John J. Masters, Jeffrey T. Mullaney, Kenneth J. Ruterbories, Michael Paal, Gerd Ruhter, Theo Schotten, Wolfgang Stenzel, Robert M. Scarborough
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Patent number: 6291469Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.Type: GrantFiled: October 5, 1998Date of Patent: September 18, 2001Assignees: Eli Lilly and Company, COR Therapeutics Inc.Inventors: Matthew J. Fisher, Joseph A. Jakubowski, John J. Masters, Jeffrey T. Mullaney, Kenneth J. Ruterbories, Michael Paal, Gerd Ruhter, Robert M. Scarborough, Theo Schotten, Wolfgang Stenzel
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Patent number: 6020362Abstract: This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: GrantFiled: March 24, 1998Date of Patent: February 1, 2000Assignee: Eli Lilly and CompanyInventors: Matthew J. Fisher, Anne Marie Happ, Joseph A. Jakubowski, Michael Dean Kinnick, Allen D. Kline, Michael John Martinelli, John Michael Morin, Jr., Michael Paal, Gerd Ruhter, Kenneth James Ruterbories, Daniel J. Sall, Theo Schotten, Marshall A. Skelton, Wolfgang Stenzel, Robert Theodore Vasileff
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Patent number: 5843938Abstract: The use of a compound of the formula: ##STR1## in which X is --O-- or --NH--, or a pharmaceutically-acceptable acid addition salt thereof, in the treatment of atherosclerosis.Type: GrantFiled: October 3, 1996Date of Patent: December 1, 1998Assignee: Beiersdorf-Lilly GmbHInventors: Hans-Juergen Mest, Wolfgang Stenzel
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Patent number: 5731324Abstract: This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.Type: GrantFiled: January 19, 1995Date of Patent: March 24, 1998Assignee: Eli Lilly and CompanyInventors: Matthew J. Fisher, Anne Marie Happ, Joseph A. Jakubowski, Michael Dean Kinnick, Allen D. Kline, Michael John Martinelli, John Michael Morin, Jr., Michael Paal, Gerd Ruhter, Kenneth James Ruterbories, Daniel J. Sall, Theo Schotten, Marshall A. Skelton, Wolfgang Stenzel, Robert Theodore Vasileff
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Patent number: 5695252Abstract: A motor-vehicle head rest has a one-piece plastic body formed with a pair of like recesses opening parallel to each other, and respective pivot assemblies in each recess. Each such pivot assembly has a holder and a pivot element held in the holder. Interengaging formations on the body and holder retain the holders in the recesses, and respective rods engage up through the pivot elements of the assemblies. Such a head rest is made by fitting the holders to the respective pivot elements, engaging the holders carrying the respective pivot elements into the respective recesses and thereby interengaging the formations and locking the holders with their pivot elements in the respective recesses, and fitting the rods through the pivot elements.Type: GrantFiled: March 25, 1996Date of Patent: December 9, 1997Assignee: R. Schmidt GmbHInventors: Reinhard Schmidt, Wolfgang Stenzel, Hermann Griech
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Patent number: 5672618Abstract: The present invention discloses compounds that are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. Accordingly, the present invention provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2. As isozyme selective inhibitors of beta-1 and beta-2, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of the beta-1 and beta-2 isozyme.Type: GrantFiled: May 25, 1995Date of Patent: September 30, 1997Assignee: Eli Lilly and CompanyInventors: William F. Heath, Jr., John H. McDonald, III, Michael Paal, Theo Schotten, Wolfgang Stenzel
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Patent number: 5664840Abstract: A motor-vehicle headrest has a hollow housing having a front face and a back face, at least one mounting rod seated in the housing and adapted to be secured to a motor-vehicle seat back, and a body of soft cushion material on the front housing face. The back face is formed with a peripheral backwardly open groove and is substantially free of cushioning. A flexible cover sheet overlies the cushion body and has an outer edge engaged in the groove. A stiff rear cover has a forwardly directed rim tightly fitted in the groove and retains the cover edge therein. The housing is formed of a pair of joined-together cup-shaped parts. The groove is formed with teeth engaging and holding the cover-sheet edge.Type: GrantFiled: November 22, 1996Date of Patent: September 9, 1997Assignee: R. Schmidt GmbHInventor: Wolfgang Stenzel
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Patent number: 5602136Abstract: Compounds having the formula ##STR1## and the other variables are as defined herein, and are indicated for use in the treatment and prophylaxis of, for example, hypertension, congestive heart failure, ocular hypertension, renal failure, and CNS disorders, or are intermediates thereto.Type: GrantFiled: May 26, 1995Date of Patent: February 11, 1997Assignee: Beiersdorf-Lilly GmbHInventors: Gerd R uhter, Theo Schotten, Wolfgang Stenzel, Michael Paal
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Patent number: 5602137Abstract: Compounds for treating cardiovascular or circulatory disorders of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1, R.sup.2, R.sup.3, R.sup.7, Ar.sup.1, Ar.sup.2, X, Y, and n are defined herein.Type: GrantFiled: May 26, 1995Date of Patent: February 11, 1997Assignee: Beiersdorf-Lilly GmbHInventors: Gerd R uhter, Theo Schotten, Wolfgang Stenzel, Michael Paal
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Patent number: 5571813Abstract: Pharmaceutical compounds which are azolo-fused pyrimidine compounds having the formula ##STR1## in which .dbd.Type: GrantFiled: June 6, 1994Date of Patent: November 5, 1996Assignee: Beiersdorf-Lilly GmbHInventors: Gerd R uhter, Theo Schotten, Wolfgang Stenzel, Michael Paal