Abstract: An apparatus and a method for crystallization and supercritical drying of culture solution are provided. According to the embodiments of the present invention, an apparatus for crystallization and supercritical drying of culture solution to obtain target material by drying a culture solution containing a first solvent and the target material dissolved in the first solvent comprises a high pressure container to accommodate the culture solution, a first supply unit connected to the high pressure container to supply a second solvent to the high pressure container, a second supply unit connected to the high pressure container to supply a third solvent to the high pressure container, a precooler disposed adjacent to the first supply unit to precool the second solvent discharged from the first supply unit, and a preheater disposed adjacent to the high pressure container to preheat the second solvent and the third solvent supplied to the high pressure container.