Abstract: An apparatus for synthesizing a biopolymer includes a reaction chamber, an outlet tube connected to the reaction chamber, a plurality of recovery tanks connected to the outlet tube, and a plurality of recovery valves configured to open or block the passageway between the outlet tube and each of the recovery tanks.

Abstract: Disclosed are substrate structures, an oligomer probe array and methods of producing the same. The substrate structure may include a substrate, and an intermediate film including the chemical structure represented by the following Formula 1, on the substrate. (wherein R1 is alkyl, aryl, alkoxy, nitrile, ester, phenyl, hydroxyl, aliphatic lactone, cycloalkyl or cycloalkenyl, R2 is alkyl, aryl, alkoxy, nitrile, ester, phenyl, hydroxyl, aliphatic lactone, cycloalkyl or cycloalkenyl, and X is coupled with the substrate directly or via an immobilization layer).

Abstract: An oligomer probe array includes a substrate, an immobilization layer on the substrate, nanoparticles coupled to the immobilization layer and forming a photonic crystal structure, and oligomer probes coupled to the nanoparticles. The immobilization layer includes probe cell regions coupled to nanoparticles. Adjacent probe cell regions are separated by a probe cell separation region.

Abstract: A microarray includes a substrate, a plurality of fine particles disposed on the substrate at regular intervals, and a plurality probes coupled with the fine particles.

Abstract: A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.

Abstract: Example embodiments may include an oligomer probe array chip based on an analysis-friendly layout. Example oligomer probe array chips may include a substrate, a main array on the substrate having a plurality of sub-arrays in rows or panels, and/or a plurality of alignment spot arrays outside of each of the sub-arrays. The sub-arrays may include a plurality of spots arranged in a matrix to which oligomer probes having different sequences may be attached. Example embodiments may further provide masks for fabricating oligomer probe array chips and hybridization analysis methods of oligomer probe array chips.

Abstract: The present invention provides a biochip kit including a first housing; a biochip disposed inside the first housing and configured to include a plurality of molecular probes; and a second housing joined to the first housing and configured to form a reaction space with the first housing and to cover the biochip, wherein the second housing and the first housing are removably joined in a configuration to allow exposure of an upper surface of the biochip. Methods of testing biological samples using the biochip kits are also provided.

Abstract: A microarray includes a substrate, a siloxane resin layer represented by the following general formula 1 or 2 and includes a siloxane resin having a molecular weight of about 1,000 to about 10,000: where R1 and R2 are independently hydrocarbons having 1 to 30 carbon atoms and X1 and X2 are independently a hydroxyl, aldehyde, carboxyl amino, amide, thiol halo, or sulfonate group, and a plurality of oligomer probes coupled with the siloxane resin layer.

Abstract: A probe array includes a substrate having at least two projecting features adjacent to one another, each feature including a top surface and a side surface, an isolation region separating the at least two features, at least two active regions, the at least two active regions including the top surfaces of the at least two features, and an inactive region separating the at least two active regions, the inactive region including the isolation region.

Abstract: A method of manufacturing a microarray includes providing a substrate having a surface that is immobilized with a functional group protected with an acid-labile protecting group and capable of coupling with an oligomer probe, providing a photoacid generator onto the substrate, disposing on the substrate an imprint template comprising a convex region and a plurality of concave regions surrounding the convex region so that the convex region contacts with or is adjacent to an upper surface of the substrate to define a plurality of reaction zones by the upper surface of the substrate and the convex region and the concave regions of the imprint template, exposing one or more of the reaction zones to light so that an acid is generated by the photoacid generator in the one or more exposed reaction zones and a functional group in the one or more exposed reaction zones is deprotected by the acid, and providing an oligomer probe onto the substrate so that the oligomer probe couples with the deprotected functional group

Abstract: An oligomer probe array with improved signal-to-noise ratio includes a substrate, a plurality of probe cell active regions formed on or in the substrate, with each of the plurality of probe cell active regions having a substantially planar surface and being coupled with at least one oligomer probe with own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.

Abstract: A non-linear silicon compound is provided. The non-linear silicon compound may be a non-linear aromatic compound used as a linker for manufacturing an oligomer probe array. The non-linear silicon compound may reduce self-aggregation so as to form a stable and uniform monolayer. As a result, upon hybridization analysis, the fluorescent intensity may be increased.

Abstract: Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.

Abstract: According to some embodiments of the invention, provided herein is a microarray comprising a substrate; a plurality of probe cells formed in the substrate, wherein at least one probe cell includes a linker; and a probe cell separation area. In addition, in some embodiments, the microarray may include a molecular probe coupled to the linker. Related methods are also described herein.

Abstract: An oligomer probe array with improved signal-to-noise ratio and desired detection sensitivity ever when a reduced design rule is employed includes a substrate, a plurality of probe cell active regions formed on or in the substrate, each of the plurality of probe cell active regions having a three-dimensional surface and being coupled, with at least one oligomer probe with its own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.

Abstract: An oligomer probe array having improved reaction yield is provided. The oligomer probe array includes a substrate, an immobilization layer on the substrate, a plurality of nano particles coupled with a surface of the immobilization layer, and a plurality of oligomer probes coupled with surfaces of the nano particles.

Abstract: A multifunctional oligomer probe array capable of simultaneously performing different analyses such as gene expression profiling and genotyping includes a substrate, a first array region, a second array region, and a column spacer. The first array region has a plurality of first probe cell active regions, one or more oligomer probes, and a first probe cell defining region, wherein the plurality of first probe cell active regions are disposed on or in the substrate. The second array region has a plurality of second probe cell active regions, one or more oligomer probes, and a second probe cell defining region, wherein the plurality of second probe cell active regions are disposed on or in the substrate. The column spacer prevents cross-talk between a target sample applied to the first array region and another target sample applied to the second array region.

Abstract: A DNA chip includes a substrate, at least one first electrode and at least one second electrode on the substrate, the first electrode and the second electrode being opposite to and separated from each other, multiple oligonucleotide probes, one end of the oligonucleotide probes being immobilized on the first electrode, and a charge-carrier transport layer on the second electrode, the charge-carrier layer contacting an other end of the oligonucleotide probes.

Abstract: A biopolymer synthesis apparatus including at least one chamber in which a biopolymer is to be synthesized includes a chamber body and a chamber cover covering the chamber body, wherein the chamber cover includes at least one through hole at an upper surface thereof, and at least one first fluid-supply pipe coupled with the chamber via the at least one through-hole of the chamber cover.

Abstract: The present invention relates to an organic-inorganic hybrid composition comprising: (a) a copolymer matrix having an organic functional group; (b) an inorganic nanoparticle having an inorganic functional group on the surface of the nanoparticle; (c) a photopolymerizable monomer; (d) a photoinitiator, and (e) a photosensitizer.