Abstract: A medical vacuum sealing drainage device, including: a porous foam soft pad (1); a drainage tube (2) including a tail end; and an elastic sealing rubber film (3). The drainage tube (2) is arranged in the porous foam soft pad (1) and the tail end thereof extends outside the porous foam soft pad (1). The elastic sealing rubber film (3) is arranged on an outer side of the porous foam soft pad (1). A sealing opening (3a) for allowing the drainage tube (2) to extend out is formed on the elastic sealing rubber film (3). A diameter of the opening portion of the sealing opening (3a) is less than the outer diameter of the corresponding extending pipe.