Abstract: Stable and bioavailable extended-release formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyrid azine-3-carboxamide (Formula (I); BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.

Abstract: Stable and bioavailable formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide (Formula (I); BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.

Abstract: Generating a cryptographic key, for example using a received external key. A system to generate a cryptographic key may include a first data store which may store an authorization key. A system may include a second data store which may store a secure key and/or a public key. A system may include an access controller, which may allow access to a secure key, for example to an access request which may be accompanied by a digital signature. A system may include a key generator, which may generate a private key, for example using a received external key, a stored authorization key and/or a mapping function. A system may include an access request signal generator which may generate a digital signature and/or which may transmit an access request, for example including a generated digital signature, to an access controller to retrieve a secure key.

Abstract: A method is provided for determining in real time the course of proteolytic, e.g., thrombin activity, in a sample of clotting blood or plasma. By frequent mixing of a sample, clot formation may be controlled in a dense manner such that the majority of the sample remains fluid. This will inhibit cell precipitation and allow for informative monitoring as signal substrate is added.

Abstract: A process for generating a number representative of an analogue data source (ADS) in which during enrolment a distinctive characteristic of the ADS is measured to obtain physical data (PD). Part of the PD is used to generate a physical value (PV) representative of the ADS. An error correction algorithm (ECA) is applied to the PV to generate error correction data (ECD), which is transformed, using another part of the PD, to generate transform data. During subsequent regeneration of the PV, the distinctive characteristic is re-measured to generate a new set of PD, and a PV is generated using the same part of the PD physical data as was used during enrolment. ECD is generated by transforming the transform data, using the same part of the PD as was used to transform the ECD during enrolment. The ECA uses the regenerated ECD to correct errors in the PV representative of the ADS.

Abstract: A captioning system is provided for providing captions for audio and/or video presentations. The captioning system can be used to provide text captions or audio descriptions of a video presentation. A user device is provided for the captioning system having a receiver operable to receive the captions together with synchronization information and a caption output circuit which is operable to output the captions at the appropriate timings defined by the synchronization information. The user device is preferably a portable hand-held device such as a mobile telephone, PDA or the like.

Abstract: There is decribed an apparatus for generating a number from data originating from an analogue source, the apparatus comprising means for performing a set of the data and then processing, in accordance with stored processing instructions predetermined by a training process, the data to generate the number. During the training process, the sensitivity of the value of the generated number to variation in each of the measurement values is analyzed, and the process instructions are generated so that the processing of individual measurement values is modified to reduce this sensitivity. In this way, the repeatability of the generated number is improved.

Abstract: There is described a communication system in which data is received by and/or transmitted to a telecommunications apparatus using an acoustic data channel. In embodiments, the data is encoded within the audio track of a media broadcast or other public broadcast. The invention has particular, but not exclusive, relevance to a cellular communication system. There are also described acoustic position detection systems for determining the position of a telecommunications apparatus.

Abstract: An industrial process control apparatus and method that includes a number of processors and a number of input/output modules. Each processor is connected to a plurality of the input/output modules by a unidirectional command line. Each input/output module is connected to a plurality of the processors by a unidirectional response line. The processors are arranged to issue an identifier request to all of the connected input/output modules and each input/output module is arranged to respond to the identifier request via the respective response line with a response that includes a unique identifier. Such a configuration allows each processor to identify the physical location of each respective input/output module.

Abstract: There is described an authentication system in which during an enrolment process a distinctive characteristic of a subject being enrolled is measured to generate a reference number representative of the subject. Authentication data is then generated using the reference number, and the authentication data is stored for use in a subsequent verification process. During verification, the representative characteristic of the subject being verified is re-measured to generate a test number representative of the subject being verified and the authentication data during enrolment is retrieved. The authentication system then checks for equality between the test number and the reference number using the retrieved authentication data. If the test number and the reference number are equal, then the authenticity of the subject is verified, otherwise the authenticity is denied.

Abstract: There is described a communication system in which data is received by and/or transmitted to a telecommunications apparatus using an acoustic data channel. In embodiments, the data is encoded within the audio track of a media broadcast or other public broadcast. The invention has particular, but not exclusive, relevance to a cellular communication system. There are also described acoustic position detection systems for determining the position of a telecommunications apparatus.

Abstract: There is described a communication system in which data is received by and/or transmitted to a telecommunications apparatus using an acoustic data channel. In embodiments, the data is encoded within the audio track of a media broadcast or other public broadcast. The invention has particular, but not exclusive, relevance to a cellular communication system. There are also described acoustic position detection systems for determining the position of a telecommunications apparatus.

Abstract: A method is provided for determining in real time the course of thrombin activity in a sample of clotting blood or plasma as it appears in and disappears from the sample which comprises adding a signal substrate to said sample, said signal substrate causing a detectable signal related to the amount of conversion product formed upon reaction by the generated proteolytic activity, monitoring the signal development in time in said sample to provide a curve, and mixing said sample frequently so that clot formation occurs in a dense manner such that the majority of the sample remains fluid and that cell precipitation is inhibited, wherein said monitoring and mixing steps are repeated and performed in an alternate way.

Abstract: An industrial process control apparatus and method that includes a number of processors and a number of input/output modules. Each processor is connected to a plurality of the input/output modules by a unidirectional command line. Each input/output module is connected to a plurality of the processors by a unidirectional response line. The processors are arranged to issue an identifier request to all of the connected input/output modules and each input/output module is arranged to respond to the identifier request via the respective response line with a response that includes a unique identifier. Such a configuration allows each processor to identify the physical location of each respective input/output module.

Abstract: A number of encoders for encoding a data signal within an audio signal are provided. In some of the encoders, the audio signal is separated into a tonal part, and a residual part, and the data signal is shaped based on the residual part. In other encoders, the data signal is separated into a tonal part and a residual part, and the data signal is combined with the audio signal independence upon the residual part. In other encoders, the rate at which the data is encoded within the audio signal is varied in dependence upon the audio signal. There are also described various decoders associated with the described encoders.

Abstract: There is described a number of encoders for encoding a data signal within an audio signal. In some of the encoders, the audio signal is separated into a tonal part and a residual part, and the data signal is shaped based on the residual part. In other encoders, the data signal is separated into a tonal part and a residual part, and the data signal is combined with the audio signal independence upon the residual part. In other encoders, the rate at which the data is encoded within the audio signal is varied in dependence upon the audio signal. There are also described various decoders associated with the described encoders.

Abstract: The combined light source and air purifier unit includes a body (11) and a centrifugal fan (12) with rearwardly facing blades (20) run at low speed and mounted by the body with its axis upright and a central intake (17) through which air containing contaminants is drawn from a target zone (80) below the unit. A light source (14) mounted within a peripheral projecting skirt (75) is located radially outside the intake (17) of the centrifugal fan (12) so as not to obstruct the flow of intake air. A filter (13) extends circumferentially around the fan (12) and an air discharge (60) includes a smoothly curved flow deflecting means (62) provided by the body (11) to deflect air flowing outwardly from the fan in an upwards direction at about 45° or less to the vertical.

Abstract: A position determining system in which a mobile tag having an unknown position is tracked in space over time. In use, the mobile tag either transmits or receives signals including a pair of tones at different frequencies from a number of base stations having known locations. The phase of each of the received signals is then measured and the measured phases are then passed to a processing unit which determines the position of the tag at the time of the transmission of the signals on the basis of the difference between the measured phases of the two tones. In one embodiment, this system is combined with a conventional phase-based position measurement which is derived from phase measurements of similar tones transmitted between the mobile tag and different base stations.

Abstract: An improved system and method for a computer-implemented auction in which multiple types of items are auctioned together without imposing a particular division of supply or demand among the individual types of items. In some embodiments the auction of the present invention provides a means or method for establishing prices for the types of items, wherein the prices maintain a relationship. In other embodiments, the present invention provides a means or method for implying prices from price parameters in the bids received form bidders, based on a relation among the prices for the types of items. Market clearing may be defined by the condition that the aggregate quantity bid for all types of items is less than or equal to the available quantity of all types of items. The division among the types of items within is thus determined flexibly, based on the bids at the associated prices.

Abstract: A position determining system in which a mobile tag having an unknown position is tracked in space over time. In use, the mobile tag either transmits or receives signals including a pair of tones at different frequencies from a number of base stations having known locations. The phase of each of the received signals is then measured and the measured phases are then passed to a processing unit which determines the position of the tag at the time of the transmission of the signals on the basis of the difference between the measured phases of the two tones. In one embodiment, this system is combined with a conventional phase-based position measurement which is derived from phase measurements of similar tones transmitted between the mobile tag and different base stations.