Abstract: Provided are methods of clinical treatment of Richter's syndrome in human subjects using a bispecific antibody which binds to CD3 and CD20.

Abstract: A multiple static vane component includes a plurality of airfoils each formed of ceramic matrix composite materials. Each of the airfoils are attached to an inner platform and an outer platform both formed of ceramic matrix composite materials. There is a plurality of individual parts forming the plurality of airfoils, the inner platform or the outer platform, bonded to each other with a braze joint. A gas turbine engine and a method are also disclosed.

Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

Abstract: An aerial device for operating on energized powerlines is disclosed. The aerial device may have a boom assembly with a lower, electrically non-insulating boom section coupled to an upper, electrically insulating boom section. The lower and upper boom sections may be coupled by a pinned connection that utilizes structural collars and structural pins to handle loads applied to the upper boom section. The upper boom section may articulate relative to the lower boom section using a 4-bar mechanism employing a split pivot pin that enables a greater range of motion for the articulation. A modular sled that can be coupled to various boom assemblies is also disclosed.

Abstract: In some embodiments, an electronic device displays an editable time input element, including a first field and a second field. In some embodiments, the electronic device receives a selection input directed to the editable time input element. In some embodiments, after receiving the selection input, the electronic device receives one or more editing inputs. In some embodiments, in response to receiving the first set of one or more editing inputs, in accordance with a determination that the selection input was a first type of input, the electronic device edits content of the first field based on the one or more editing inputs and in accordance with a determination that the selection input was a second type of input, different from the first type, the electronic device edits content of the first field and the second field based on the one or more editing inputs.

Abstract: A processor for supporting secure memory intent is disclosed. The processor of the disclosure includes a memory execution unit to access memory and a processor core coupled to the memory execution unit. The processor core is to receive a request to access a convertible page of the memory. In response to the request, the processor core to determine an intent for the convertible page in view of a page table entry (PTE) corresponding to the convertible page. The intent indicates whether the convertible page is to be accessed as at least one of a secure page or a non-secure page.

Abstract: A device having a sheath, a medical device, a stylet, a handle and a plunger device. The handle includes portions connected proximal ends of the sheath, the medical device and the stylet and a chamber portion connected to the actuator. The chamber portion includes a volume of space configured to volumetrically connect to at a lumen of the medical device, the sheath or the stylet and a plunger device configured to be slidably received within the chamber portion. The plunger device is able to pneumatically isolate a proximal portion of the volume of space from a distal portion of the volume of space. Proximal movement of the stylet and the plunger device cause a suction effect (i.e., reduced pressure) at the distal end of the sheath, the medical device and/or the stylet.

Abstract: A process and apparatus integrate recovery of propylene from a pyrolysis reactor and a paraffin dehydrogenation reactor. A common depropanizer fractionates propane feed and pyrolysis reactor effluent to provide a C3 stream. A dividing wall may be used in the column to prevent cross contamination by the pyrolysis effluent with the propane dehydrogenation feed.

Abstract: A process and apparatus integrate recovery of propylene from a pyrolysis reactor and a paraffin dehydrogenation reactor. The improved process for recovering light olefins utilizes heats of compression to heat reboil streams.

Abstract: A process and apparatus integrate recovery of propylene from a pyrolysis reactor and a paraffin dehydrogenation reactor. A common C3 splitter column fractionates propylene product from propane recycle to a paraffin dehydrogenation reactor. The C3 hydrocarbons may be provided from a pyrolysis reactor and from a dehydrogenation reactor.

Abstract: An unmanned aerial vehicle (UAV) for transporting a payload is provided. The UAV comprises a body and one or more propellers rotatably connected to the body. The UAV further comprises a battery mounted to the body. The battery is releasable from the bottom of the UAV. The UAV further comprises a payload container mounted to the body. The payload container is releasable from the bottom of the UAV to a landing platform associated with a UAV station.

Abstract: A method for processing a CMC airfoil includes nesting an airfoil fiber preform in a cavity of a fixture that has first and second tool segments, closing the fixture by rotating a first tool segment about a hinge, the closing causing the tool segments to clamp on a tail portion of the fiber preform and thereby conform the tail portion to the fixture. While in the fixture, the fiber preform is then partially densified with an interface coating material to form a partially densified fiber preform. While still in the fixture, one or more cooling holes are drilled into the trailing edge of the partially densified fiber preform. After the drilling, the partially densified fiber preform is removed from the fixture and further densified with a ceramic matrix material to form a fully densified CMC airfoil.

Abstract: An analyte sensor comprising: a non-conductive material; a conductive material disposed on the non-conductive material; and at least two sensing structures defined by a removed portion of the conductive material, the at least two sensing structures comprising a reagent composition.

Abstract: A finger-mounted device may include finger-mounted units. The finger-mounted units may each have a body that serves as a support structure for components such as force sensors, accelerometers, and other sensors and for haptic output devices. The body may have sidewall portions coupled by a portion that rests adjacent to a user's fingernail. The body may be formed from deformable material such as metal or may be formed from adjustable structures such as sliding body portions that are coupled to each other using magnetic attraction, springs, or other structures. The body of each finger-mounted unit may have a U-shaped cross-sectional profile that leaves the finger pad of each finger exposed when the body is coupled to a fingertip of a user's finger. Control circuitry may gather finger press input, lateral finger movement input, and finger tap input using the sensors and may provide haptic output using the haptic output device.

Abstract: A process and apparatus integrate recovery of propylene from a pyrolysis reactor and a paraffin dehydrogenation reactor. A stripping column for fractionating a dehydrogenation stream is coupled with a demethanizer column for fractionating a pyrolyzed stream. The stripping overhead stream comprising C2? hydrocarbons are fractionated with the pyrolyzed stream in the demethanizer column. The coupling omits the need for a conventional deethanizer column and separate refrigeration system in the propane dehydrogenation unit.

Abstract: A process and apparatus cool a pyrolyzed stream and a dehydrogenated stream in respective cold boxes by use of a refrigerant compressed with a common compressor. The refrigerant is compressed and used to cool a pyrolysis cold box and a dehydrogenation cold box.

Abstract: In accordance with at least one aspect of this disclosure, an isolated drive (e.g., for a generator controller) includes a gate driver configured to operatively connect to a switch to drive the switch between a first state and a second state, a transformer configured to power the gate driver and provide an ON/OFF signal to the gate driver, an input line configured to connect a first side of the transformer to the gate driver, and a floating return line configured to connect a second side of the transformer directly to a source terminal of the switch such that parasitic currents from the transformer and/or drive circuit bypasses the gate driver and flows to the floating return line.

Abstract: In some embodiments, an electronic device presents representations of messaging conversations. In some embodiments, an electronic device indicates which messages are replies to other messages in a messaging conversation. In some embodiments, an electronic device creates and presents links (e.g., rich links) to contacts in a messaging conversation (e.g., “mentions”). In some embodiments, an electronic device presents indications of messages that are replies to other messages. In some embodiments, an electronic device presents options to create a link (e.g., a rich link) to contacts in a messaging conversation (e.g., “mentions”) using a suggested entry user interface element.

Abstract: The present disclosure provides systems and methods for refilling fluid containers. A fluid container may include a bottle and a valve assembly. The valve assembly may include two valves and be configured to engage with the bottle and a filling head or dispensing head. A system is configured to provide pressurized fluid to the refillable container, monitor filling, determine when to stop filling, and determine how much fluid was provided. The valve assembly may include a float mechanism coupled to one of the valves of the valve assembly to ensure fluid flow is stopped when the fluid container is full. The fluid, which can include carbon dioxide, is stored in a storage tank. A flow system provides the fluid to a filling head, which engages with the fluid container. The flow system includes a transfer pump, valves, and sensors configured to provide the fluid to the filling head.

Abstract: Disclosed in the present invention are a series of fused polycyclic substituted 5-carboxylic acid thienopyrimidine dione compounds and the use thereof. Specifically disclosed are a compound represented by formula (H) and a pharmaceutically acceptable salt thereof.