Abstract: Some embodiments are directed to a device for a surgical instrument, including at least one sensor, a circuit for controlling and processing signals coming from the at least one sensor, a memory for storing information coming from the circuit, and a radio interface for transmitting this information to an external device, the sensor(s), the circuit, the memory and the radio interface being powered by a power source, the circuit, the memory, the radio interface and the power source being housed in one or several hermetic and heat and pressure resistant case(s), in order to allow an autonomous operation of the device.

Abstract: Some embodiments are directed to a device for a surgical instrument, including at least one sensor, a circuit for controlling and processing signals coming from the at least one sensor, a memory for storing information coming from the circuit, and a radio interface for transmitting this information to an external device, the sensor(s), the circuit, the memory and the radio interface being powered by a power source, the circuit, the memory, the radio interface and the power source being housed in one or several hermetic and heat and pressure resistant case(s), in order to allow an autonomous operation of the device.

Abstract: The present invention relates to benzimidazolyl-methyl urea derivatives of formula (I), wherein n, D, E, R1, R2, R3, R4, R6, R7, R8 and R9 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The present invention relates to benzimidazolyl-methyl urea derivatives of formula (I), wherein n, D, E, R1, R2, R3, R4, R6, R7, R8 and R9 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: A modular acetabular impactor and reamer system including a main body extending between a proximal handle end and a distal end. The system also includes a transmission rotatingly extending within the main body. The transmission has an accessory mount. The system also has at least one of an impactor handle and a reamer handle removably coupled to the main body proximal handle end. The impactor handle has a drive shaft to drive rotation relative to the impactor handle. The reamer handle has a drive mount to drive rotation relative to the reamer handle. The system also has at least one of an impactor cup and a reamer module removably coupled to the main body distal end. The transmission and the at least one of the impactor cup and the reamer module correspondingly rotate relative to the main body.

Abstract: The invention relates to hydroxylated aminotriazole derivatives of formula (I), wherein Q, R1, R2, R3 and R4 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The invention relates to a method for preparing linear polymers having an amide end or having a star architecture comprising an amide core, by means of a ring opening using lactide and glycolide monomers or a lactide monomer ring in the presence of a catalyst, wherein the method includes the steps of: (i) reacting the excess monomer(s) with an initiator in a solvent, said initiator being selected from among an amine and an amino alcohol, given that the initiator has at least one primary or secondary amine function; (ii) adding a catalyst, said catalyst being a non-nucleophilic base and including at least one neutral sp2 nitrogen atom; and (iii) neutralizing the reaction mixture. Said novel method is particularly advantageous in that it can be easily monitored and enables better modulation of the polymers, and thus of the properties thereof, than the methods of the prior art. The invention also relates to novel polymers that are obtainable by means of said method.

Abstract: The invention relates to the identification of Neuropeptide Q as ligand of the GALR2 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of GALR2 polypeptides and Neuropeptide Q polypeptides as the basis of screening assays for agents that modulate the activity of the GALR2 receptor. The invention also encompasses diagnostic assays based upon the GALR2/Neuropeptide Q polypeptide interaction, as well as kits for performing diagnostic and screening assays.

Abstract: The invention relates to oxazolyl-methylether derivatives of formula (I), wherein R1, R2, R3, R4 and R5 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: An acetabular cup impactor for surgery. The impactor has a handle, a bow arm and a prehension fastener secured to the bow arm opposite the handle. An elongated spine extends within the length of the bow arm between the handle and the prehension fastener. In use, the elongated spine rotates with respect to the bow arm and causes corresponding rotation of the prehension fastener with respect to the bow arm.

Abstract: The invention relates to the identification of Humanin and derivatives thereof as ligands of the GPR1 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of GPR1 polypeptides and Humanin polypeptides as the basis of screening assays for agents that modulate the activity of the GPR1 receptor. The invention also encompasses diagnostic assays based upon the GPR1/Humanin polypeptide interaction, as well as kits for performing diagnostic and screening assays.

Abstract: The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.

Abstract: The invention relates to hydroxylated aminotriazole derivatives of formula (I), wherein Q, R1, R2, R3 and R4 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The invention relates to oxazolyl-methylether derivatives of formula (I), wherein R1, R2, R3, R4 and R5 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: The invention relates to a method for preparing linear polymers having an amide end or having a star architecture comprising an amide core, by means of a ring opening using lactide and glycolide monomers or a lactide monomer ring in the presence of a catalyst, wherein the method includes the steps of: (i) reacting the excess monomer(s) with an initiator in a solvent, said initiator being selected from among an amine and an amino alcohol, given that the initiator has at least one primary or secondary amine function; (ii) adding a catalyst, said catalyst being a non-nucleophilic base and including at least one neutral sp2 nitrogen atom; and (iii) neutralizing the reaction mixture. Said novel method is particularly advantageous in that it can be easily monitored and enables better modulation of the polymers, and thus of the properties thereof, than the methods of the prior art. The invention also relates to novel polymers that are obtainable by means of said method.

Abstract: The invention relates to the identification of Neuropeptide Q as ligand of the GALR2 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of GALR2 polypeptides and Neuropeptide Q polypeptides as the basis of screening assays for agents that modulate the activity of the GALR2 receptor. The invention also encompasses diagnostic assays based upon the GALR2/Neuropeptide Q polypeptide interaction, as well as kits for performing diagnostic and screening assays.

Abstract: The inventive method for controlling access to data which is used by reference in a program execution system (including processes and aims) during the program execution consists in memorising by the system the totality of references obtainable by said program with the aid of means considered legal, before any operation which can be prohibited if it relates to values which are not legal references, in verifying by the system whether said values are amongst the legal references memorized for the program and in accepting or rejecting the operation, respectively.