Abstract: The present invention provides new pharmaceutical and vaccine compositions comprising Treponema spp. bacterins, supplemented with antigens from Treponema spp. or other digital dermatitis causative pathological agents such as but not limited to D. nodosus or F. necrophorum, for effectively immunizing susceptible mammals, preferably ungulates, against DD, in particular against bovine digital dermatitis. The present invention also identifies Treponema pedis and Treponema phagedenis as two of the etiologic agents of digital dermatitis (DD) in mammals, in particular ungulate digital dermatitis. The invention therefore also provides isolated cultures of Treponema pedis and Treponema phagedenis for effectively immunizing susceptible mammals, preferably ungulates, against DD, in particular against bovine digital dermatitis. In addition, the present invention provides methods of diagnosing DD by detecting infection with a series of specific Treponema antigens.

Abstract: The present invention provides new pharmaceutical and vaccine compositions comprising Treponema spp. bacterins, supplemented with antigens from Treponema spp. or other digital dermatitis causative pathological agents such as but not limited to D. nodosus or F. necrophorum, for effectively immunizing susceptible mammals, preferably ungulates, against DD, in particular against bovine digital dermatitis. The present invention also identifies Treponema pedis and Treponema phagedenis as two of the etiologic agents of digital dermatitis (DD) in mammals, in particular ungulate digital dermatitis. The invention therefore also provides isolated cultures of Treponema pedis and Treponema phagedenis for effectively immunizing susceptible mammals, preferably ungulates, against DD, in particular against bovine digital dermatitis. In addition, the present invention provides methods of diagnosing DD by detecting infection with a series of specific Treponema antigens.

Abstract: The present disclosure is directed to the sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid, pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: The present disclosure is directed to novel crystalline addition salts of (i) tromethamine with (ii) an azabiphenylaminobenzoic acid derivatives of formula (I), pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: The present disclosure is directed to the sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid, pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: A process for preparing 3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one which process comprises the steps of: (a) reacting 1-phenylbutane-1,3-dione with ethyl 2-chloro-2-(hydroxyimino)actetate; and (b) subsequently reacting the product from step (a) with hydrazine or an hydrate thereof to yield 3-methyl-4-phenylisoxazolo-[3,4-d]pyridin-7(6H)-one, wherein step (b) is carried out on the mixture resulting from step (a) without isolating ethyl 4-benzoyl-5-methylisoxazole-3-carboxylate therefrom.

Abstract: An apparatus is constructed for converting an input voice signal into an output voice signal according to a target voice signal. In the apparatus, an input device provides the input voice signal composed of original sinusoidal components and original residual components other than the original sinusoidal components. An extracting device extracts original attribute data from at least the sinusoidal components of the input voice signal. The original attribute data is characteristic of the input voice signal. A synthesizing device synthesizes new attribute data based on both of the original attribute data derived from the input voice signal and target attribute data being characteristic of the target voice signal composed of target sinusoidal components and target residual components other than the sinusoidal components. The target attribute data is derived from at least the target sinusoidal components.

Abstract: A voice converting apparatus is constructed for converting an input voice into an output voice according to a target voice. The apparatus includes a storage section, an analyzing section including a characteristic analyzer, a producing section, a synthesizing section, a memory, an alignment processor, and target decoder.

Abstract: An apparatus is constructed for converting an input voice signal into an output voice signal according to a target voice signal. In the apparatus, an input device provides the input voice signal composed of original sinusoidal components and original residual components other than the original sinusoidal components. An extracting device extracts original attribute data from at least the sinusoidal components of the input voice signal. The original attribute data is characteristic of the input voice signal. A synthesizing device synthesizes new attribute data based on both of the original attribute data derived from the input voice signal and target attribute data being characteristic of the target voice signal composed of target sinusoidal components and target residual components other than the sinusoidal components. The target attribute data is derived from at least the target sinusoidal components.

Abstract: A voice converter synthesizes an output voice signal from an input voice signal and a reference voice signal. In the voice converter, an analyzer device analyzes a plurality of sinusoidal wave components contained in the input voice signal to derive a parameter set of an original frequency and an original amplitude representing each sinusoidal wave component. A source device provides reference information characteristic of the reference voice signal. A modulator device modulates the parameter set of each sinusoidal wave component according to the reference information. A regenerator device operates according to each of the parameter sets as modulated to regenerate each of the sinusoidal wave components so that at least one of the frequency and the amplitude of each sinusoidal wave component as regenerated varies from original one, and mixes the regenerated sinusoidal wave components altogether to synthesize the output voice signal.

Abstract: A singing voice synthesizing apparatus is provided, which enables achievement of a natural sounding synthesized singing voice with a good level of comprehensibility. A phoneme database stores a plurality of voice fragment data formed of voice fragments each being a single phoneme or a phoneme chain of at least two concatenated phonemes, each of the plurality of voice fragment data comprising data of a deterministic component and data of a stochastic component. A readout device that reads out from the phoneme database the voice fragment data corresponding to inputted lyrics. A duration time adjusting device adjusts time duration of the read-out voice fragment data so as to match a desired tempo and manner of singing. An adjusting device adjusts the deterministic component and the stochastic component of the read-out voice fragment so as to match a desired pitch.

Abstract: A voice converting apparatus is constructed for converting an input voice into an output voice according to a target voice. In the apparatus, a storage section provisionally stores source data, which is associated to and extracted from the target voice. An analyzing section analyzes the input voice to extract therefrom a series of input data frames representing the input voice. A producing section produces a series of target data frames representing the target voice based on the source data, while aligning the target data frames with the input data frames to secure synchronization between the target data frames and the input data frames. A synthesizing section synthesizes the output voice according to the target data frames and the input data frames. In the recognizing feature analysis, a characteristic analyzer extracts from the input voice a characteristic vector. A memory memorizes target behavior data representing a behavior of the target voice.

Abstract: A voice converting apparatus is constructed for converting an input voice into an output voice according to a target voice. In the apparatus, a storage section provisionally stores source data, which is associated to and extracted from the target voice. An analyzing section analyzes the input voice to extract therefrom a series of input data frames representing the input voice. A producing section produces a series of target data frames representing the target voice based on the source data, while aligning the target data frames with the input data frames to secure synchronization between the target data frames and the input data frames. A synthesizing section synthesizes the output voice according to the target data frames and the input data frames.

Abstract: An apparatus is constructed for converting an input voice signal into an output voice signal according to a target voice signal. In the apparatus, an input device provides the input voice signal composed of original sinusoidal components and original residual components other than the original sinusoidal components. An extracting device extracts original attribute data from at least the sinusoidal components of the input voice signal. The original attribute data is characteristic of the input voice signal. A synthesizing device synthesizes new attribute data based on both of the original attribute data derived from the input voice signal and target attribute data being characteristic of the target voice signal composed of target sinusoidal components and target residual components other than the sinusoidal components. The target attribute data is derived from at least the target sinusoidal components.

Abstract: An apparatus is constructed for converting an input voice signal into an output voice signal according to a target voice signal. In the apparatus, an input device provides the input voice signal composed of original sinusoidal components and original residual components other than the original sinusoidal components. An extracting device extracts original attribute data from at least the sinusoidal components of the input voice signal. The original attribute data is characteristic of the input voice signal. A synthesizing device synthesizes new attribute data based on both of the original attribute data derived from the input voice signal and target attribute data being characteristic of the target voice signal composed of target sinusoidal components and target residual components other than the sinusoidal components. The target attribute data is derived from at least the target sinusoidal components.

Abstract: An apparatus is constructed for converting an input voice signal into an output voice signal according to a target voice signal. In the apparatus, an input device provides the input voice signal composed of original sinusoidal components and original residual components other than the original sinusoidal components. An extracting device extracts original attribute data from at least the sinusoidal components of the input voice signal. The original attribute data is characteristic of the input voice signal. A synthesizing device synthesizes new attribute data based on both of the original attribute data derived from the input voice signal and target attribute data being characteristic of the target voice signal composed of target sinusoidal components and target residual components other than the sinusoidal components. The target attribute data is derived from at least the target sinusoidal components.

Abstract: A singing voice synthesizing apparatus is provided, which enables achievement of a natural sounding synthesized singing voice with a good level of comprehensibility. A phoneme database stores a plurality of voice fragment data formed of voice fragments each being a single phoneme or a phoneme chain of at least two concatenated phonemes, each of the plurality of voice fragment data comprising data of a deterministic component and data of a stochastic component. A readout device that reads out from the phoneme database the voice fragment data corresponding to inputted lyrics. A duration time adjusting device adjusts time duration of the read-out voice fragment data so as to match a desired tempo and manner of singing. An adjusting device adjusts the deterministic component and the stochastic component of the read-out voice fragment so as to match a desired pitch.

Abstract: A voice converter synthesizes an output voice signal from an input voice signal and a reference voice signal. In the voice converter, an analyzer device analyzes a plurality of sinusoidal wave components contained in the input voice signal to derive a parameter set of an original frequency and an original amplitude representing each sinusoidal wave component. A source device provides reference information characteristic of the reference voice signal. A modulator device modulates the parameter set of each sinusoidal wave component according to the reference information. A regenerator device operates according to each of the parameter sets as modulated to regenerate each of the sinusoidal wave components so that at least one of the frequency and the amplitude of each sinusoidal wave component as regenerated varies from original one, and mixes the regenerated sinusoidal wave components altogether to synthesize the output voice signal.

Abstract: Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid with the formula (I), where: ?A.ident.F, Cl or Br; X.ident.O, NH or NR (R.ident.C.sub.1 -C.sub.8 alkyl); R.sub.1 and R.sub.2 independently.ident.C.sub.1 -C.sub.8 alkyl and n is a whole number from 1 to 10. The procedure includes the condensation of 2-(2,6-diahlophenylamino) phenylacetoxyacetic acid with a compound with the formula: ##STR1## where Y.ident.OH, NH.sub.2 or NHR and Z is Cl, Br or ONO.sub.2.

Abstract: Analysis data are provided which are indicative of plural components making up an original sound waveform. The analysis data are analyzed to obtain a characteristic concerning a predetermined element, and then data indicative of the obtained characteristic is extracted as a sound or musical parameter. The characteristic corresponding to the extracted musical parameter is removed from the analysis data, and the original sound waveform is represented by a combination of the thus-modified analysis data and the musical parameter. These data are stored in a memory. The user can variably control the musical parameter. A characteristic corresponding to the controlled musical parameter is added to the analysis data. In this manner, a sound waveform is synthesized on the basis of the analysis data to which the controlled characteristic has been added. In such a sound synthesis technique of the analysis type, it is allowed to apply free controls to various sound elements such as a formant and a vibrato.