Patents by Inventor Xi Zhan

Xi Zhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of the interaction between Arp2/3 and cortactin or HS-1
    Patent number: 7192702
    Abstract: The invention relates to methods for screening compounds for their ability to modulate actin polymerization. The invention is also related to compounds which modulate actin polymerization. More specifically, the invention is related to methods of screening compounds which modulate the interaction of cortactin or HS-1 with Arp2/3. The invention is also related to compounds which modulate the interaction of cortactin of HS1 with Arp2/3. Also provided are mutants of cortactin with decreased ability to interact with Arp2/3.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: March 20, 2007
    Assignee: University of Maryland, Baltimore
    Inventors: Xi Zhan, Takehito Uruno
  • Inhibitors of cell migration and shape changes by inhibiting cortactin and hs-1 medicated actin polymerization
    Publication number: 20040038323
    Abstract: The invention relates to methods for screening compounds for their ability to modulate actin polymerization. The invention is also related to compounds which modulate actin polymerization. More specifically, the invention is related to methods of screening compounds which modulate the interaction of cortactin or HS-1 with Arp2/3. The invention is also related to compounds which modulate the interaction of cortactin of HS1 with Arp2/3. Also provided are mutants of cortactin with decreased ability to interact with Arp2/3.
    Type: Application
    Filed: February 27, 2003
    Publication date: February 26, 2004
    Inventors: Xi Zhan, Takehito Uruno
  • Oncogene encoded polypeptide having growth factor activity and methods of use thereof
    Patent number: 5238916
    Abstract: This invention provides a purified polypeptide having growth factor activity and a defined amino acid sequence. The invention also provides a purified nucleic acid molecule encoding the polypeptide. This invention further provides methods for producing the polypeptide as well as uses thereof. Finally, this invention provides methods for detecting the polypeptide.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: August 24, 1993
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Mitchell Goldfarb, Xi Zhan
  • Ongogene encoding polypeptide having growth factor activity
    Patent number: 5155217
    Abstract: This invention provides a purified polypeptide having growth factor activity and a defined amino acid sequence. The invention also provides a purified nucleic acid molecule encoding the polypeptide. This invention further provides methods for producing the polypeptide as well as uses thereof. Finally, this invention provides methods for detecting the polypeptide.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: October 13, 1992
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Mitchell Goldfarb, Xi Zhan