Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.

Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.

Abstract: The present application relates to a kind of fused ring phenolic compound, or a pharmaceutically acceptable salt or ester thereof, in the manufacture of medicaments for treating, inhibiting or preventing bacterial infections. The disclosed fused ring phenolic compounds can inhibit PPK1 and PPK2 and can be used to treat infections or conditions caused by bacteria such as Pseudomonas aeruginosa.

Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: A resource scheduling method and a communication apparatus. In the method, a terminal device receives first indication information for determining a quantity of layers to be scheduled corresponding to each frequency domain unit in a plurality of frequency domain units, or for determining a quantity of layers to be scheduled corresponding to each frequency domain unit group in one or more frequency domain unit groups, where one frequency domain unit group includes one or more frequency domain units, one frequency domain unit includes one or more frequency domain resources with a same quantity of layers to be scheduled; and determines, based on the first indication information, a quantity of layers to be scheduled that are on frequency domain resources for data transmission, where at least two of the frequency domain resources for data transmission have different quantities of layers to be scheduled.

Abstract: Embodiments of the present technology relate to semiconductor processing methods that include providing a structured semiconductor substrate including a trench having a bottom surface and top surfaces. The methods further include depositing a portion of a silicon-containing material on the bottom surface of the trench for at least one deposition cycle, where each deposition cycle includes: depositing the portion of the silicon-containing material on the bottom surface and top surfaces of the trench, depositing a carbon-containing mask layer on the silicon-containing material on the bottom surface of the trench, where the carbon-containing mask layer is not formed on the top surfaces of the trench, removing the portion of the silicon-containing material from the top surfaces of the trench, and removing the carbon-containing mask layer from the silicon-containing material on the bottom surface of the trench, where the as-deposited silicon-containing material remains on the bottom surface of the trench.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a manual of joint and bone disorders such as arthritis and osteoporosis.

Abstract: Disclosed is a method for task planning of a space information network based on resource interchange. The method includes: initializing basic parameters of the space information network; dividing a planning horizon into K time slots of equal length, and constructing a resource time-varying graph for the space information network; sampling a feasible resource combination space of each task, and obtaining a candidate resource combination set comprised of the resource combinations with independence greater than or equal to a threshold n; calculating a conflict relation between resource combinations, and constructing a resource combination conflict graph; obtaining a maximum independent set of the resource combination conflict graph to obtain a global planning result; and searching a neighborhood of the global planning result, and completing a local adjustment of a task planning scheme through the resource interchange, to complete the task planning based on characteristics of the resource interchange.

Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.

Abstract: The disclosed systems and methods are directed towards: i) receiving at least one Yet Another Next Generation (YANG) data model, ii) converting the at least one YANG data model into a corresponding Forest Data Store (FDS) binary format, wherein the FDS binary format is divided into four areas: forest data area, meta-data area, string area, and dynamic area, and iii) transmitting the FDS binary format to at least one of: a server-network device and a client device/network management system. The systems and methods are also directed towards: i) receiving a request for configuration of the server-network device, and ii) processing the request based on the FDS binary format corresponding to at least one YANG data model.

Abstract: The disclosed systems and methods for extracting a subtree structure from a YANG schema, the YANG schema comprising one or more YANG models, being a ramified hierarchical structure defining a plurality of nodes and relationships among the plurality of nodes and being representable under the form of a tree structure. The method comprises receiving the YANG schema and a set of extraction instructions, the extraction instructions comprising indication of one or more first nodes to be extracted from the YANG model. The one or more first nodes are further added to a set of nodes to be extracted. The method comprises executing an iterative identification process to update the set of nodes to be extracted, and further generating a trimmed YANG model based on the set of nodes to be extracted.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: A vehicle and an insulation monitoring circuit for vehicle battery, the insulation monitoring circuit acquiring power from the vehicle battery and comprising a voltage-to-frequency conversion circuit (11), an RC series circuit (12), a first peak sampling circuit (13), and an alarm trigger module (14); the voltage-to-frequency conversion circuit (11) outputs a low-frequency pulse signal and injects same via the RC series circuit (12) into a high-voltage system connected to the vehicle battery; the first peak sampling circuit (13) performs sampling on a voltage signal of a resistor rear end in the RC series circuit (12) and feeds back same to the voltage-to-frequency conversion circuit (11), such that the outputted low-frequency pulse signal is adapted to the vehicle battery; and the alarm trigger module (14) performs processing on the voltage signal of the resistor rear end in the RC series circuit (12) and outputs an alarm trigger signal.

Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.

Abstract: Systems and methods include receiving a traceroute packet at a relay node; responding to the traceroute packet with a first data structure inside the traceroute packet that indicates a propagation mode at the node and an operation type performed at the node, receiving subsequent traceroute packets from the initiator node with a second data structure inside the subsequent traceroute packets with data used to indicate changes in a header of the subsequent traceroute packets, and forwarding the subsequent traceroute packets with the changes to the header based on the data. The systems and methods can include utilizing the first data structure to determine the changes in the header of the subsequent traceroute packets. This can be used in Multiprotocol Label Switching (MPLS), Segment Routing (SR), and Internet Protocol (IP), where a TTL/Hop Limit propagation is limited.

Abstract: A VEGF inhibitor is used in preparation of a medicament for treating hypoxia-related diseases. The VEGF inhibitor can significantly inhibit VEGF stress expression caused by hypoxia by acting on a binding pathway of VEGF and a VEGF receptor, is used for treating hypoxia and other related diseases, can significantly improve the oxygenation index of a patient, and can alleviate the hypoxic state of lung and other organ tissues, having good therapeutic effects.

Abstract: A media access control (MAC) address allocation method and device are disclosed. The method includes: a wireless access point device sending a notification message on a wireless medium. The notification message includes at least one candidate virtual MAC address. The wireless access point device receiving, on the wireless medium, a request message from a terminal device. A source address of the request message is a first virtual MAC address. The first virtual MAC address is one of the at least one candidate virtual MAC address.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.