Patents by Inventor Xiangmin Liao

Xiangmin Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2 substituted cephem compounds
    Patent number: 10174053
    Abstract: The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: January 8, 2019
    Assignees: Glaxo Group Limited, Shionogi and Co., Ltd.
    Inventors: Toshiaki Aoki, Hiroki Kusano, Xiangmin Liao, Neil David Pearson, Israil Pendrak, Jun Sato, Reema K. Thalji, Kenji Yamawaki, Katsuki Yokoo
  • 2 SUBSTITUTED CEPHEM COMPOUNDS
    Publication number: 20170281532
    Abstract: The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: April 18, 2017
    Publication date: October 5, 2017
    Inventors: Toshiaki AOKI, Hiroki KUSANO, Xiangmin LIAO, Neil David PEARSON, Israil PENDRAK, Jun SATO, Reema K. THALJI, Kenji YAMAWAKI, Katsuki YOKOO
  • Antibacterial compounds
    Patent number: 9340556
    Abstract: The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: May 17, 2016
    Assignees: GLAXO GROUP LIMITED, SHIONOGI & CO., LTD
    Inventors: Xiangmin Liao, Neil David Pearson, Israil Pendrak, Masayuki Sano
  • 2-SUBSTITUTED CEPHEM COMPOUNDS
    Publication number: 20150299223
    Abstract: The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.
    Type: Application
    Filed: October 29, 2013
    Publication date: October 22, 2015
    Inventors: Toshiaki AOKI, Hiroki KUSANO, Xiangmin LIAO, Neil David PEARSON, Israil PENDRAK, Jun SATO, Reema THALGI, Kenji YAMAWAKI, Katsuki YOKOO
  • Crystalline form of carbamoyl-cyclohexane derivatives
    Patent number: 8912197
    Abstract: The present invention relates to novel crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel co-crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl urea hydrochloride and an acid such as fumaric acid. Processes for preparing these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 16, 2014
    Inventors: Xiangmin Liao, Hiajian (Jim) Zhu, Andreas Grill
  • Peptide deformylase inhibitors
    Patent number: 8901119
    Abstract: The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: December 2, 2014
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Yuhong Fang, James Hoffman, Joseph M. Karpinski, Andrew Nicholson Knox, Xiangmin Liao, Donghui Qin, Dongchuan Shi, Jared T. Spletstoser
  • ANTIBACTERIAL COMPOUNDS
    Publication number: 20140249126
    Abstract: The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.
    Type: Application
    Filed: October 4, 2012
    Publication date: September 4, 2014
    Inventors: Xiangmin Liao, Neil David Pearson, Israil Pendrak, Masayuki Sano
  • CRYSTALLINE FORM OF CARBAMOYL-CYCLOHEXANE DERIVATIVES
    Publication number: 20140051710
    Abstract: The present invention relates to novel crystalline forms of carbarmoyl-cyclohexane derivatives and, more particularly, to novel co-crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethly urea hydrochloride and an acid such as fumaric acid. Processes for preparing these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 20, 2014
    Inventors: Xiangmin Liao, Hiajian (Jim) Zhu, Andreas Grill
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20130345120
    Abstract: The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
    Type: Application
    Filed: March 9, 2012
    Publication date: December 26, 2013
    Applicant: Glaxosmithkline LLC
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Yuhong Fang, James Hoffman, Joseph M. Karpinski, Andrew Nicholson Knox, Xiangmin Liao, Donghui Qin, Dongchuan Shi, Jared T. Spletstoser
  • Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
    Patent number: 8609665
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: December 17, 2013
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20130045962
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined below and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Application
    Filed: November 6, 2008
    Publication date: February 21, 2013
    Inventors: Donghui Qin, Beth Norton, Xiangmin Liao, Andrew Nicholson Knox, Jinhwa Lee, Yuhong Fang, Jason Christopher Dreabit, Siegfried Benjamin Christensen, IV, Andrew B. Benowitz, Kelly M. Aubart
  • NOVEL SOLVATE AND CRYSTALLINE FORMS OF CARBAMOYL-CYCLOHEXANE DERIVATIVES
    Publication number: 20110028722
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Application
    Filed: October 5, 2010
    Publication date: February 3, 2011
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
    Patent number: 7829569
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: November 9, 2010
    Assignee: Forest Laboratories Holdings Limited
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • Peptide deformylase inhibitors
    Patent number: 7745637
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: June 29, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Kelly M. Aubart, Ajita Bhat, Sigfried B. Christensen, IV, Jack D. Leber, Xiangmin Liao
  • NOVEL SOLVATE AND CRYSTALLINE FORMS OF CARBAMOYL-CYCLOHEXANE DERIVATIVES
    Publication number: 20090030007
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Application
    Filed: May 9, 2008
    Publication date: January 29, 2009
    Applicant: FOREST LABORATORIES HOLDINGS LIMITED
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • Peptide deformylase inhibitors
    Patent number: 7456211
    Abstract: The present invention involves novel anti-bacterial compounds represented by Formula (I), pharmaceutical compositions thereof, their use as PDF inhibitors, and their use in the treatment of bacterial infections.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: November 25, 2008
    Assignee: SmithKline Beecham Corp
    Inventors: Kelly M. Aubart, Jia-Ning Xiang, Siegfried B. Christensen, IV, Xiangmin Liao, Maxwell D. Cummings
  • Pharmaceutical Formulation and Process
    Publication number: 20070196364
    Abstract: A process for lyophilization or freeze-drying of a pharmaceutical product is provided and a liquid formulation suitable for lyophilization. In particular, a process for lyophilization or freeze-drying a liquid formulation that includes a protein active agent, a bulking agent and a saccharide stabilizing agent is provided. The saccharide to bulking agent ratio and the protein concentration of the formulation are important factors that affect crystallization of the bulking agent during lyophilization and storage as are some processing conditions. In one embodiment, the saccharide is a disaccharide, such as sucrose and the crystalline bulking agent is mannitol. The protein can be an antibody or a non-antibody protein.
    Type: Application
    Filed: January 23, 2007
    Publication date: August 23, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Rajesh Krishnamurthy, Raj Suryanarayanan, Xiangmin Liao
  • Peptide Deformylase Inhibitors
    Publication number: 20070155792
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: March 7, 2007
    Publication date: July 5, 2007
    Inventors: Kelly Aubart, Jia-Ning Xiang, Siegfried Christensen, Xiangmin Liao, Maxwell Cummings
  • Peptide Deformylase Inhibitors
    Publication number: 20070155810
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: February 16, 2007
    Publication date: July 5, 2007
    Inventors: Kelly Aubart, Ajita Bhat, Sigfried Christensen, Jack Leber, Xiangmin Liao
  • Peptide deformylase inhibitors
    Publication number: 20060025412
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: October 14, 2005
    Publication date: February 2, 2006
    Inventors: Kelly Aubart, Jia-Ning Xiang, Siegfried Christensen, Xiangmin Liao, Maxwell Cummings