Abstract: The present application discloses a sealing valve (10), including a guiding tube (1), comprising a first end (11) configured to be inserted into an outer packaging bottle and a second end configured to be connected to an anesthesia vaporizer (12); the outer peripheral surface of the first end (11) is provided with a convex ring (111) protruding toward the inner wall of the outer packaging bottle and abutting against the inner wall of the outer packaging bottle; and a pushing rod (2) configured to be arranged in the guiding tube (1) and slidable along an axial direction of the guiding tube (1) to connect the anesthesia vaporizer with the outer packaging bottle or to block between the anesthesia vaporizer and the outer packaging bottle.

Abstract: A connecting valve structure and an anesthetic filling system are provided. When a valve core assembly is in the open state, a pipe and a filling port are in seal fit, besides, the connecting ring, the seal pipe, and the drug guiding pipe are integrated as a whole, when the seal pipe is inserted into or pulled out of the filling port of the evaporator, no BHT exudate occurs. In addition, an inner pipe wall of the seal pipe, a surface of the connecting ring facing towards a first pipe end, and an outer pipe wall of the drug guiding pipe opposite to the seal pipe together form a pressure stabilizing groove which is used to equilibrate pressure in the container and the evaporator during the open state.

Abstract: A connecting valve structure and an anesthetic filling system are provided. When a valve core assembly is in the open state, a pipe and a filling port are in seal fit, besides, the connecting ring, the seal pipe, and the drug guiding pipe are integrated as a whole, when the seal pipe is inserted into or pulled out of the filling port of the evaporator, no BHT exudate occurs. In addition, an inner pipe wall of the seal pipe, a surface of the connecting ring facing towards a first pipe end, and an outer pipe wall of the drug guiding pipe opposite to the seal pipe together form a pressure stabilizing groove which is used to equilibrate pressure in the container and the evaporator during the open state.

Abstract: Provided is an anti-angiogenic fusion protein, which comprises a vascular endothelial cell growth inhibitor (VEGI) or variant thereof, and other polypeptide such as IgG Fc. The fusion protein optionally comprises a linker. The fusion protein can induce the apoptosis of endothelial cells and inhibit the growtth of endothelial cells, so as to be used for treating tumor. Also provided are a pharmaceutical composition and use of the fusion protein.

Abstract: A cell-detaching reactor is provided to prepare single cell suspension for inoculation of anchorage-dependent cells between the scaled-up bioreactors, which is especially useful in a commercial-scale process. The cell-detaching reactor of the invention comprises a trypsinizing zone and a separating zone, which are separated by a screen with mesh size between the diameters of the cells and the carriers.