Patents by Inventor Xiangxing Kong

Xiangxing Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF ANTIGENS
    Publication number: 20230314427
    Abstract: Provided herein are methods for detecting and identifying disease-specific biomarkers, such as target antigens associated with infection.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 5, 2023
    Inventors: Ye Hu, Xiangxing Kong, Tanxi Cai, Qingbo Shu
  • Device and method for high-throughput multiparameter measurements in one or more live and fixed cells
    Patent number: 11364502
    Abstract: A microfluidic device includes a first substrate including at least one microfluidic channel and a plurality of microwells, as well as a cooperating second substrate defining multiple split-walled cell trap structures that are registered with and disposed within the plurality of microwells. A method for performing an assay includes flowing cells and a first aqueous medium into a plurality of microwells of a microfluidic device, wherein each microwell includes a cell trap structure configured to trap at least one cell. The method further comprises flowing a nonpolar fluid with low permeability for analytes of interest through a microfluidic channel to flush a portion of the first aqueous medium from the microfluidic channel while retaining another portion of the first aqueous medium and at least one cell within each microwell. Surface tension at a non-polar/polar medium interface prevents molecule exchange between interior and exterior portions of microwells.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: June 21, 2022
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Wacey Teller, Meryl Rodrigues, Hong Wang, Ganquan Song, Yanqing Tian, Fengyu Su, Xiangxing Kong, Liqiang Zhang
  • Fluorescent pH sensors and methods of preparing them
    Patent number: 11156619
    Abstract: Fluorescent pH sensors are provided. The fluorescent pH sensor comprises a copolymer for sensing pH and a polymerized form of N-(2-hydroxypropyl)methacrylamide (HPMA) or 2-hydroxyethyl methacrylate (HEMA). The probe for sensing pH has formula (I): wherein R1 and R2 are as defined herein. The fluorescent pH sensors may be used in determining the pH of a sample and detecting extracellular pH in a sample. Methods for preparing the fluorescent pH sensors and the probe for sensing pH are also provided.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: October 26, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Liqiang Zhang, Xiangxing Kong, Yanqing Tian, Deirdre Meldrum, Fengyu Su
  • Mitochondria-targeting fluorescent potassium+ sensor and method of making the same
    Patent number: 10590155
    Abstract: Mitochondria-targeting potassium sensors and method(s) for making such sensors. The sensor shows a response to potassium and displays a 130-fold dynamic range of fluorescence intensity and high brightness. The sensors response to potassium concentrations was demonstrated to be unaffected by cellular pH value and/or concentrations of other ions. The sensors can be used for monitoring the mitochondrial potassium efflux/influx.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: March 17, 2020
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Xiangxing Kong, Yanqing Tian, Fengyu Su, Liqiang Zhang, Deirdre Meldrum
  • A DEVICE AND METHOD FOR HIGH-THROUGHPUT MULTIPARAMETER MEASUREMENTS IN ONE OR MORE LIVE AND FIXED CELLS
    Publication number: 20200047182
    Abstract: A microfluidic device includes a first substrate including at least one microfluidic channel and a plurality of microwells, as well as a cooperating second substrate defining multiple split-walled cell trap structures that are registered with and disposed within the plurality of microwells. A method for performing an assay includes flowing cells and a first aqueous medium into a plurality of microwells of a microfluidic device, wherein each microwell includes a cell trap structure configured to trap at least one cell. The method further comprises flowing a nonpolar fluid with low permeability for analytes of interest through a microfluidic channel to flush a portion of the first aqueous medium from the microfluidic channel while retaining another portion of the first aqueous medium and at least one cell within each microwell. Surface tension at a non-polar/polar medium interface prevents molecule exchange between interior and exterior portions of microwells.
    Type: Application
    Filed: November 14, 2016
    Publication date: February 13, 2020
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Wacey Teller, Meryl Rodrigues, Hong Wang, Ganquan Song, Yanqing Tian, Fengyu Su, Xiangxing Kong, Liqiang Zhang
  • FLUORESCENT pH SENSORS AND METHODS OF PREPARING AND USING THEM
    Publication number: 20190360984
    Abstract: The present disclosure relates to an optical luminescence dual sensor comprising a polymerized form of a probe for sensing pH; a polymerized form of a probe for sensing oxygen; a polymerized form of an internal reference probe; and a matrix. The present disclosure also relates to methods of preparing an optical luminescence dual sensor and methods of using them.
    Type: Application
    Filed: January 19, 2018
    Publication date: November 28, 2019
    Inventors: Liqiang Zhang, Xiangxing Kong, Yanqing Tian, Deirdre Meldrum, Fengyu Su
  • MITOCHONDRIA-TARGETING FLUORESCENT POTASSIUM+ SENSOR AND METHOD OF MAKING THE SAME
    Publication number: 20190153005
    Abstract: Mitochondria-targeting potassium sensors and method(s) for making such sensors. The sensor shows a response to potassium and displays a 130-fold dynamic range of fluorescence intensity and high brightness. The sensors response to potassium concentrations was demonstrated to be unaffected by cellular pH value and/or concentrations of other ions. The sensors can be used for monitoring the mitochondrial potassium efflux/influx.
    Type: Application
    Filed: July 14, 2017
    Publication date: May 23, 2019
    Inventors: Xiangxing Kong, Yanqing Tian, Fengyu Su, Liqiang Zhang, Deirdre Meldrum
  • Acetylene polymers and their use as liquid crystals
    Patent number: 7070712
    Abstract: There is disclosed a liquid crystalline polyacetylene having a repeat structure of the formula where spa is a spacer group and mes is a mesogenic substituent.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: July 4, 2006
    Assignee: The Hong Kong University of Science & Technology
    Inventors: Ben Zhong Tang, Wing Yip Lam, Xiangxing Kong, Hoi Sing Kwok
  • Acetylene polymers and their use as liquid crystals
    Publication number: 20060022169
    Abstract: There is disclosed a liquid crystalline polyacetylene having a repeat structure of the formula where spa is a spacer group and mes is a mesogenic substituent.
    Type: Application
    Filed: April 12, 2005
    Publication date: February 2, 2006
    Applicant: The Hong Kong University of Science & Technology
    Inventors: Ben Tang, Wing Lam, Xiangxing Kong, Hoi Kwok
  • Acetylene polymers and their use as liquid crystals
    Publication number: 20040140449
    Abstract: There is disclosed a liquid crystalline polyacetylene having a repeat structure of the formula 1
    Type: Application
    Filed: November 13, 2003
    Publication date: July 22, 2004
    Applicant: The Hong Kong University of Science & Technology
    Inventors: Ben Zhong Tang, Wing Yip Lam, Xiangxing Kong, Hoi Sing Kwok
  • Acetylene polymers and their use as liquid crystals
    Publication number: 20030164474
    Abstract: There is disclosed a liquid crystalline polyacetylene having a repeat structure of the formula 1
    Type: Application
    Filed: January 17, 2003
    Publication date: September 4, 2003
    Applicant: The Hong Kong University of Science & Technology
    Inventors: Ben Zhong Tang, Wing Yip Lam, Xiangxing Kong, Hoi Sing Kwok
  • Acetylene polymers and their use as liquid crystals
    Publication number: 20020033474
    Abstract: There is disclosed a liquid crystalline polyacetylene having a repeat structure of the formula 1
    Type: Application
    Filed: February 20, 2001
    Publication date: March 21, 2002
    Inventors: Ben Zhong Tang, Wing Yip Lam, Xiangxing Kong, Hoi Sing Kwok