Patents by Inventor Xianzhu YANG

Xianzhu YANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein-type nanoparticles, preparation methods, and application thereof
    Patent number: 11957764
    Abstract: The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (?Fc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: April 16, 2024
    Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Jun Wang, Zhiting Cao, Song Shen, Qianni Ye, Xiaojiao Du, Xianzhu Yang, Youyong Yuan
  • PROTEIN-TYPE NANOPARTICLES, PREPARATION METHODS, AND APPLICATION THEREOF
    Publication number: 20230173100
    Abstract: The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (?Fc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.
    Type: Application
    Filed: January 27, 2023
    Publication date: June 8, 2023
    Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Jun WANG, Zhiting CAO, Song SHEN, Qianni YE, Xiaojiao DU, Xianzhu YANG, Youyong YUAN