Patents by Inventor Xiao-Fan Wang

Xiao-Fan Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-LMP2 TCR-T CELL THERAPY FOR THE TREATMENT OF EBV-ASSOCIATED CANCERS
    Publication number: 20220056101
    Abstract: The present disclosure provides compositions comprising anti-LMP2 TCR-T cell populations for the treatment of EBV-associated cancers and methods of making and using same.
    Type: Application
    Filed: November 26, 2019
    Publication date: February 24, 2022
    Inventors: Xiao-Fan Wang, Peter Alexander, Qi-Jing Li, Guoping Wang
  • ANTI-LYPD3 CAR T-CELL THERAPY FOR THE TREATMENT OF CANCER
    Publication number: 20210309711
    Abstract: The present disclosure relates to a chimeric antigen receptor (CAR) molecule that specifically binds LYPD3, and also provides compositions comprising CAR T-cell-derived effector cells specific for LYPD3 and methods of making and using same.
    Type: Application
    Filed: July 19, 2019
    Publication date: October 7, 2021
    Applicant: DUKE UNIVERSITY
    Inventors: Qi-Jing Li, Xiao-Fan Wang, Mengyang Chong, Rui Chen
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF SENESCENT TUMOR CELLS
    Publication number: 20210161900
    Abstract: The present disclosure comprises compositions and methods for the treatment of senescent tumor cells. In particular, compositions and methods for countering negative effects of cancer therapy-induced senescence in tumor cells are provided.
    Type: Application
    Filed: April 29, 2019
    Publication date: June 3, 2021
    Inventors: Xiao-Fan Wang, Christopher Pan, Lifeng Yuan
  • TGF-beta type receptor cDNAs encoded products and uses therefor
    Publication number: 20080234216
    Abstract: DNA encoding TGF-? type III receptor of mammalian origin, DNA encoding TGF-? type II receptor of mammalian origin, TGF-? type III receptor, TGF-? type II receptor and uses therefor.
    Type: Application
    Filed: July 24, 2007
    Publication date: September 25, 2008
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • TGF-beta type receptor cDNAs encoded products and uses therefor
    Publication number: 20060247198
    Abstract: DNA encoding TGF-? type III receptor of mammalian origin, DNA encoding TGF-? type II receptor of mammalian origin, TGF-? type III receptor, TGF-? type II receptor and uses therefor.
    Type: Application
    Filed: April 10, 2006
    Publication date: November 2, 2006
    Inventors: Herbert Lin, Xiao-Fan Wang, Robert Weinberg, Harvey Lodish
  • TGF-beta type receptor cDNAs encoded products
    Publication number: 20050260579
    Abstract: DNA encoding TGF-? type III receptor of mammalian origin, DNA encoding TGF-? type II receptor of mammalian origin, TGF-? type III receptor, TGF-? type II receptor and uses therefor.
    Type: Application
    Filed: April 18, 2003
    Publication date: November 24, 2005
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Herbert Lin, Xiao-Fan Wang, Robert Weinberg, Harvey Lodish
  • TGF-&bgr; type receptor cDNAs encoded products and uses therefor
    Patent number: 6201108
    Abstract: DNA encoding TGF-&bgr; TYPE III receptor of mammalian origin, DNA encoding TGF-&bgr; type II receptor of mammalian origin, TGF-&bgr; type III receptor, TGF-&bgr; type II receptor and uses therefor.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: March 13, 2001
    Assignee: Whitehead Institute for Medical Research
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • Modulation of TGF-.beta. by TGF-.beta. type III receptor polypeptides
    Patent number: 6086867
    Abstract: DNA encoding TGF-.beta. TYPE III receptor of mammalian origin, DNA encoding TGF-.beta. type II receptor of mammalian origin, TGF-.beta. type III receptor. TGF-.beta. type II receptor and uses therefor.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: July 11, 2000
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • Modulation of TGF-.beta. by recombinant TGF-.beta. type II receptor polypeptides
    Patent number: 6046157
    Abstract: The mammalian TGF-.beta. type II receptor has been cloned. Recombinant TGF-.beta.-binding receptor polypeptides are useful to alter the binding of TGF-.beta. to its receptors and to modulate the effects of TGF-.beta. in vivo.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 4, 2000
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • Recombinant production of TGF-.beta. type III receptor (betaglycan) polypeptides
    Patent number: 6010872
    Abstract: The invention provides cDNAs encoding the human and rodent transforming growth factor-beta (TGF-.beta.) type III receptors. Nucleic acids encoding the mammalian receptors and soluble receptor polypeptides derived from them, expression systems for their production, and the polypeptides per se also provided.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: January 4, 2000
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • TGF-.beta. type II receptor cDNAs
    Patent number: 6008011
    Abstract: The mammalian TGF-.beta. type II receptor has been cloned. Nucleic acids encoding full-length and soluble receptor polypeptides, as well as fragments of such nucleic acids useful as probes, are provided. Corresponding vectors, transformed host cells, and their use to produce recombinant TGF-.beta. receptors are also described.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 28, 1999
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • Recombinant TGF-.beta. type II receptor polypeptides
    Patent number: 6001969
    Abstract: The mammalian TGF-.beta. type II receptor has been cloned. Recombinant full-length and soluble receptor polypeptides, as well as TGF-.beta.-binding fragments of such polypeptides, are provided.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: December 14, 1999
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Herbert Y. Lin, Xiao-Fan Wang, Robert A. Weinberg, Harvey F. Lodish
  • Nucleic acids encoding a TGF-.beta. type 1 receptor
    Patent number: 5538892
    Abstract: Isolated DNAs (e.g., cDNAs or genomic fragments) encoding TGF-.beta. type I receptors, or soluble, ligand-binding fragments thereof; vectors or cells which contain such DNAs; and substantially pure polypeptides encoded by such DNAs, whether produced by expression of the isolated DNAs, by isolation from natural sources, or by chemical synthesis.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: July 23, 1996
    Assignees: The General Hospital Corporation, Duke University
    Inventors: Patricia K. Donahoe, Michael Gustafson, Wei-Wu He, Xiao-Fan Wang