Abstract: A system for monitoring impedance of excitable cells in vitro, which includes a device for monitoring cell-substrate impedance at 20 millisecond resolution, which includes a nonconductive substrate with one or more electrode arrays fabricated in one or more wells, wherein cell attachment on the substrate can result in a detectable change in impedance between electrodes within each electrode array; an impedance analyzer capable of impedance measurement at 20 millisecond time resolution; electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and a software program that controls said electronic circuitry and records and analyzes data obtained from said impedance analyzer.

Abstract: A system for monitoring impedance of excitable cells in vitro, which includes a device for monitoring cell-substrate impedance at 20 millisecond resolution, which includes a nonconductive substrate with one or more electrode arrays fabricated in one or more wells, wherein cell attachment on the substrate can result in a detectable change in impedance between electrodes within each electrode array; an impedance analyzer capable of impedance measurement at 20 millisecond time resolution; electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and a software program that controls said electronic circuitry and records and analyzes data obtained from said impedance analyzer.

Abstract: An action corrections system includes an interface and a processor. The interface is configured to receive generic data and proprietary data. The processor is configured to determine a generic data entity; match the generic data entity to a proprietary data entity to form a joined entity; determine a response variable from the proprietary data; determine a need for action corrections in regards to the joined entity based at least in part on the response variable; and determine one or more action corrections in regards to the joined entity.

Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

Abstract: This invention involves a method and a device for enhanced oil-water separation and desalination in a low-pressure separator. The water-containing oil is mixed with desalted water in a countercurrent way at the entrance, wherein the desalted water accounts for 0-1% of the water-containing oil by volume. The resultant oil-water mixture then enters a T-shaped liquid-gas separator (3) for degassing treatment to quickly separate gas from the mixture. In a low-pressure separator, the oil-water mixture flows, from left to right, to a flow conditioner (4) to uniformly distribute the mixture in the transverse section, and then flows to a hydrophilic droplet agglomeration module (5) and a CPI fast separation module (6) to separate water from oil, wherein part of the separated water is discharged and the oil with a trace of water (0-0.01%) passes over a partition (18) to a deep separation segment.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

Abstract: A composition for forming a coating is provided including at least one oxysilane-containing polymer or oligomer having an oxysilane group and at least one other organic crosslinkable group; an endcapping agent; and a solvent. A coated substrate, wherein the substrate is a silicon wafer or coated silicon wafer, includes an organic planarization layer in contact with the substrate, a photoresist layer, and a middle layer positioned between the organic planarization layer and the photoresist layer. The middle layer is formed from a composition including at least one oxysilane-containing polymer or oligomer having an oxysilane group and at least one other organic crosslinkable group, an endcapping agent; and a solvent.

Abstract: A method of identifying a potential therapeutic compound that affects a Receptor Tyrosine Kinase (RTK) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a RTK pathway and a RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells.

Abstract: The present invention relates to a device for liquid degassing by means of swirling or centrifugal force coupled with a pressure gradient. This device comprises a cavity. The cavity is furnished with an inlet for liquid-gas mixture, a gas outlet and a liquid outlet. The gas outlet is inserted into the cavity through the top end of the cavity and positioned around 0.1-3 times the maximum diameter of the cavity from the top of the cavity. Specifically, an overflow pipe with the diameter gradually increasing from the bottom to the top was used as the gas outlet. The overflow pipe is further furnished with a bell mouth at the bottom part.

Abstract: Disclosed herein are technologies for remote debugging in mobile web applications using a platform-independent debugging proxy server. Particularly, the debugging proxy server acts as an intermediary by fetching and performing instrumentation on a requested webpage by a target browser. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

Abstract: The present invention discloses a machining technology of a low-temperature high-strength-ductility high manganese steel, high manganese steel plate, and high manganese steel tube, and a high manganese steel comprises the following components in percentage by weight: Mn 30%-36%, C 0.02%-0.06%, S?0.01%, P?0.008% and the balance being Fe. Smelted steel ingots are subject to solution treatment and are rolled and homogenized to obtain a high manganese steel plate or are drawn to form a high manganese steel tube. The hot-rolled or cold-rolled steel plate after being hot-rolled has tremendous application value in the fields of low-temperature applications, such as the steel plate used for a low temperature pressure container.

Abstract: An antenna and an active antenna system to reduce complexity and power consumption of an antenna device, and reduce production costs, where the antenna includes an antenna array, a multichannel front-end, a multi-beam receiving network, and a multi-beam transmitting network. The antenna array includes w antenna elements, the multi-beam transmitting network is configured to perform beamforming processing on j transmit signal beams to obtain m transmit signals, the multichannel front-end is configured to convert w first radio-frequency signals received by the w antenna elements into n received signals, and convert the m transmit signals obtained by the multi-beam transmitting network into w second radio-frequency signals, where both n and m are less than or equal to w, and the multi-beam receiving network is configured to perform beamforming processing on the n received signals generated by the multichannel front-end to obtain k received signal beams.

Abstract: Methods of identifying whether a biologically active agent affects an oncogene addicted pathway within a cancer cell, by introducing a biologically active agent suspected of affecting an oncogene addicted pathway to a first well and a negative control to a second well, and introducing a stimulating agent that stimulates the oncogene addicted pathway to both wells; monitoring cell-substrate impedance of the two wells and optionally determining cell indices from impedance values; generating an impedance based curve for each of the two wells from the impedance values or from the cell indices; comparing the impedance-based curves to determine a degree of similarity; and if significantly different concluding the biologically active agent affects the oncogene addicted pathway within the cancer cells.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.

Abstract: A traffic data stream aggregate query method and system includes the steps of acquiring spatial-temporal information of a mobile object to generate a traffic data stream, dividing data space into cells, grouping adjacent cells with similar frequency into few buckets, calculating Kalman gains of the buckets based on frequencies of the buckets, and indexing the buckets using a binary partition tree to form a BPT index of the current timestamp, and serializing the BPT after the end of the current timestamp to form a historical index; and performing aggregate query, wherein an optimum estimation value of the bucket frequency is utilized to replace for calculating when the frequency of the bucket changes a lot. The system includes: an information collection module, a data processing module, an index processing module, an application service module and an index storage module.

Abstract: A method of determining a beating parameter of cells that undergo excitation contraction coupling, the method including providing a cell analysis device having a substrate and a sensor that measures cell adhesion or attachment to the substrate in millisecond time resolution; adding excitable cells capable of undergoing excitation contraction coupling to the substrate; monitoring cell adhesion or attachment of the excitable cells to the substrate in millisecond time resolution; and calculating one or more beating parameters from the monitored adhesion.

Abstract: Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.

Abstract: Techniques and configurations for establishing cross-domain communications between a business application, a third party website or service, and mashup components of a mashup user interface are generally described herein. In one example embodiment, a scripting library which establishes socket connections between domains and between components of a common mashup user interface is included or referenced in a mashup component and in a third party component that are displayed in the common browser-based mashup user interface. A scripting library executing in the browser may be used to establish and control the socket connections that communicate changes to the business application data, transmitted from the third party webpage to the mashup. The changes to the business application data, communicated and received in front-end objects, then may be processed or further communicated for persistence at the business application.