Abstract: An anti-MASP-2 antibody and use thereof. The anti-MASP-2 antibody specifically binds to a human MASP-2 protein at a KD value of about 2E-09M or less, and the anti-MASP-2 antibody specifically binds to a cynomolgus monkey MASP-2 protein at a KD value of about 2E-09M or less. Disclosed are an immunoconjugate containing the anti-MASP-2 antibody, a method for preparing the anti-MASP-2 antibody, and use of the anti-MASP-2 antibody.

Abstract: The present invention provides a preparation of a Siglec-15 binding protein and the use thereof, and specifically relates to an isolated antigen-binding protein, which comprises HCDR3. Provided is the use of the antigen-binding protein in the prevention and treatment of diseases.

Abstract: Provided is an GARP protein antibody, and a cell comprising or expressing the GA RP protein antibody. The GARP protein antibody binds to human GARP/human TGF-?1 complex with a KD value of about 1.0E-12 or less. Also provided are a pharmaceutical combination comprising the GARP protein antibody and an immune checkpoint inhibitor and use thereof.

Abstract: The present invention relates to the production of capsaicinoid compounds including Capsaicin and Nonivamide via microbial fermentation.

Abstract: A drilling tool includes an outer cylinder; a power rotary shaft arranged in an inner chamber of the outer cylinder; a percussion generator arranged below the power rotary shaft, having a transmission shaft extending in the outer cylinder and can be driven by the power rotary shaft to rotate around its axis, an output main shaft engaged with a lower end of the transmission shaft so as to be driven by the transmission shaft to rotate about its axis and is movable relative to the transmission shaft along an axial direction, and an percussion assembly The percussion assembly is arranged between an annulus formed between the upper end of the output main shaft and the outer cylinder and can generate reciprocating impact along the axial direction on the output main shaft. A drilling bit connected with the output main shaft extending out of the inner chamber of the outer cylinder.

Abstract: A speed-enhancing drilling tool includes an upstream drill string (10), which has a drive motor and a first driving rod coupled therewith, a downstream drilling bit; and a percussive device connected between the upstream drilling string and the downstream drilling bit. The first driving rod extending axially and the drive motor are configured to drive the first driving rod in rotation. The percussive device has a rotary driving part having an upper end engaged with the first driving rod to rotate together therewith; and a rotary working part having an upper end engaged with a lower end of the rotary driving part and a lower end connected with the downstream drilling bit. The rotary working part can be driven by the rotary driving part to rotate about its axis, and axially movable relative thereto; and a percussion generating part arranged around the rotary working part.

Abstract: A request may be received to evacuate data from a database system associated with a designated computing pod that provides on-demand computing services to a plurality of entities via the internet. The data may include portions that each correspond with a respective one or more of the on-demand computing services. Data succession policies associated with the data may be identified, where each data succession policy corresponds with one of the data portions and identifies one or more constraints associated with evacuating the data portion. The data portions may be transmitted to recipient computing pods in accordance with the data succession policies, and removed from the database system.

Abstract: Techniques and structures to prevent exhaustion of a database connection pool, including retrieving data from the database connection pool, monitoring the data to determine whether the connection pool is at risk of an exhaustion condition, analyzing the data to determine whether one or more clients accessing the database connection pool are offenders upon determining that the connection pool is at risk and throttling access to the one or more clients accessing the database connection pool upon determining the one or more clients to be offenders.

Abstract: A first copy of a database object may be constructed prior to applying a designated database update request to a first database. The database object may be represented by a plurality of database table rows in the first database, and the request may update one or more of the plurality of rows. The request may be applied to the first database to update the one or more of the plurality of rows in the first database. A second copy of the database object may be constructed after applying the database update request to the first database. A message identifying a difference between the first copy of the database object and a second copy of the database object may be transmitted to a remote computing device.

Abstract: A request for an organization migration to move application data and application services of an organization hosted at a source system instance in a multi-tenant computing system to a target system instance in the multi-tenant computing system is received. Based on operational parameters, a time window is selected to execute the organization migration. Computing resource usages of one or both of the source and target system instances in the selected time window are monitored. If computing resources are available, the organization migration is enqueued.

Abstract: A request may be received to evacuate data from a database system associated with a designated computing pod that provides on-demand computing services to a plurality of entities via the internet. The data may include portions that each correspond with a respective one or more of the on-demand computing services. Data succession policies associated with the data may be identified, where each data succession policy corresponds with one of the data portions and identifies one or more constraints associated with evacuating the data portion. The data portions may be transmitted to recipient computing pods in accordance with the data succession policies, and removed from the database system.

Abstract: A resource utilization level and a data size may be determined for each organization within a computing pod located within an on-demand computing services organization configured to provide computing services. One of the organizations may be selected for migration away from the computing pod based on the resource utilization levels and the data sizes. The designated organization may have a respective resource utilization level that is high in relation to its respective data size.

Abstract: Messages are transmitted to first and second server groups in an on-demand computing services environment. The first message instructs the first server group to reduce a first resource allocation level associated with a network-accessible computing resource, while the second message instructs the second server group to increase a second resource allocation level associated with the resource. The resource allocation levels designate respective proportions of the network-accessible computing resource shared among the server groups. Request traffic associated with providing services via the on-demand computing services environment is transferred from the first server group to the second server group after decreasing the first resource allocation level and increasing the second resource allocation level.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for security analysis are provided. One of the methods includes: determining a data risk value for data of an endpoint based on a number of classified files within the data and a type of classified files within the data; determining an endpoint risk value for the endpoint based on a user risk value and a cyber security risk value; determining a channel risk value for a set of channels through which the data is conveyable by the endpoint based on a number of channels within the set of channels and a type of channels within the set of channels; and rendering a map showing a security risk level of the endpoint, wherein the security risk level is based on the data risk value, the endpoint risk value, and the channel risk value.

Abstract: A request may be received to relocate source data within a distributed database system arranged in a hierarchy composed of a plurality of levels. The plurality of levels may include a local level that includes a plurality of pods, which may be end points in the hierarchy. The data may be stored at a source pod. The request may identify a designated level in the hierarchy at which to relocate the source data. A target pod within the distributed database system may be selected. The source pod and the target pod may be located remotely from one another. The data may be replicated to the target pod via a local change bus in communication with the source pod. The local change bus may capture changes made to data stored in the source pod and transmit the captured changes to the target pod via the hierarchy.

Abstract: Techniques and structures to prevent exhaustion of a database connection pool, including retrieving data from the database connection pool, monitoring the data to determine whether the connection pool is at risk of an exhaustion condition, analyzing the data to determine whether one or more clients accessing the database connection pool are offenders upon determining that the connection pool is at risk and throttling access to the one or more clients accessing the database connection pool upon determining the one or more clients to be offenders.

Abstract: Techniques and structures to prevent exhaustion of a database connection pool, including retrieving data from the database connection pool, monitoring the data to determine whether the connection pool is at risk of an exhaustion condition, analyzing the data to determine whether one or more clients accessing the database connection pool are offenders upon determining that the connection pool is at risk and throttling access to the one or more clients accessing the database connection pool upon determining the one or more clients to be offenders.

Abstract: Techniques are disclosed relating to processing data stored within database tables in a parallelized manner. In various embodiments, a computer system maintains a database having a database table storing data for a plurality of tenants and an index structure storing indexes for accessing data stored in the database table. In some embodiments, the computer system receives, from a particular tenant, a request to perform a task that includes operating on particular data. In some embodiments, the computer system determines a portion of the index structure corresponding to the particular tenant and divides a range of indexes within that portion into a plurality of index sub-ranges. In various embodiments, the computer system processes portions of the task in parallel by determining an index sub-range for each of a plurality of threads and causing each of the threads to operate on a portion of the particular data specified by its index sub-range.

Abstract: A request may be received to migrate an organization from a first computing pod to a second computing pod located within an on-demand computing services organization configured to provide computing services. A migration resource utilization profile may be determined for the first computing pod. The migration resource utilization profile may identify one or more computing resources involved in transferring organizations from the first computing pod during one or more time windows. A migration time window for performing the requested migration may be selected based at least in part on the migration resource utilization profile.

Abstract: A staging table created in a database system may store a snapshot of live database table captured prior to an unintended change to the live database table. One or more entries in the staging table may be updated to incorporate one or more intended changes to the live database table that occurred after the unintended change. The live database table may be updated by merging each of the updated entries from the staging table to the live database table. The updated database table may eliminate the unintended change.