Abstract: A system and method for automatic computation of MR imaging scan parameters include a computer programmed to acquire a first set of MR data from an imaging subject, the first set of MR data comprising a plurality of slices acquired at a first field-of-view. The computer is also programmed to reconstruct the plurality of slices into a plurality of localizer images and identify a 3D object based on the plurality of localizer images. The computer is further programmed to prescribe a scan, execute the prescribed scan to acquire a second set of MR data, and reconstruct the second set of MR data into an image. The prescribed scan includes one of a reduced field-of-view based on a boundary of the 3D object and a shim region based on the boundary of the 3D object.

Abstract: A system for dynamic optimization of gain and contrast in ultrasound imaging includes an image processor module programmed to dynamically estimate a correction profile in real-time and apply the correction profile to adjust a gain and contrast of image frame data sets. The image processor module is programmed to identify tissue and background regions in an image frame data set, determine an image intensity for each of the tissue and background regions, and formulate a gain profile based on the image intensity of the tissue region to compensate the gain variation of an image. The image processor module is further programmed to calculate an image contrast metric based on the image intensity of the tissue and background regions, and modify a gray map of the image frame data set based on the image contrast metric to adjust the contrast of an image displayed on the display system.

Abstract: An anomaly detection method and system for comparing a scanned object to an idealized object is provided. The anomaly detection method includes generating a three-dimensional reference model of the idealized object. The anomaly detection method further includes acquiring at least one two-dimensional inspection test image of the scanned object. The anamoly detection method also includes determining a two-dimensional reference image from the three-dimensional reference model using multiple pose parameters, wherein the two-dimensional reference image corresponds to the same view of the three-dimensional reference model of the idealized object as the view of the two-dimensional inspection test image of the scanned object. The anamoly detection method further includes identifying one or more defects in the inspection test image via automated defect recognition technique.

Abstract: A signal processing method include steps initializing a residual data signal representative of an acquired data signal, determining a significant coefficient corresponding to the residual data signal, updating the residual data signal using the significant coefficient to generate updated residual data signal, iteratively determining significant coefficients to generate a plurality of significant coefficients using the updated residual data signal, updating the plurality of significant coefficients by using a successive approximation technique, to improve the numerical accuracy of the significant coefficients and reconstructing a data signal using the updated plurality of significant coefficients.

Abstract: A variable view imaging system for observation of micro object with variable view orientation and position includes a telecentric lens group, a scanning mirror, wedge prisms, a deformable mirror and related optical elements. The combination of a scanning mirror and a telecentric lens group decouples the motion of scanning mirror and the view angle. The view angle is determined only by the angle of the wedge prisms. This design increases the zenith angle of the view and simplifies the kinematics of the system. The wedge prisms and the scanning mirror can supply a flexible view in a compact way. The wavefront error induced by the wedge prisms is corrected by the deformable mirror. In order to achieve the desired view state during operation, the scanning mirror angle and the wedge prisms angle are calculated iteratively based on the kinematics and Jacobian matrix of system.

Abstract: A method of determining an anatomically consistent scan protocol for an object of interest includes obtaining a volumetric image of an object of interest to be imaged, transforming the volumetric image, estimating the position and orientation of the object using the volumetric image and the transformed volumetric image, and modifying the imaging scan protocol using the estimated object position and orientation.

Abstract: A method for motion compensation includes acquiring an initial volumetric localizer to establish an initial object position and initial object orientation at an initial state, acquiring a fast localizer of the object at a present state, aligning the fast localizer to the initial volumetric localizers to determine object motion between the initial state and the present state, and modifying an imaging protocol using the object position and orientation at the present state.

Abstract: A method for determining 3D distances on a 2D pixelized image of a part or object includes acquiring a real 2D pixelized image of the object, creating a simulated image of the object using the 3D CAD model and the 2D pixelized image, determining a specified cost function comparing the simulated image with the real 2D pixilated image and repositioning the simulated image in accordance with iterated adjustments of a relative position between the CAD model and the XID pixilated image to change the simulated image until the specified cost function is below a specified value. Then, the workstation is used to generate a 3D distance scale matrix using the repositioned simulated image, and to measure and display distances between selected pixels on a surface of the real image using 2D distances on the 2D pixelized image of the object and the 3D distance scale matrix.

Abstract: The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically.

Abstract: Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence.

Abstract: The present techniques include methods and systems for finding correspondences between tissue spots in tissue microarray serial sections belonging to the same recipient block. The present techniques may also be used to relate individual tissue cores to clinical information. Using either a whole slide image or the relative x-y coordinates of the tissue spots on the slide, individual tissue spots in different tissue microarrays may be linked to one another and their clinical information.

Abstract: The present techniques provide fully automated methods for quantifying the location, strength and percent of expressed target molecules or other biological markers in immunohistochemically stained biological samples. The samples may be automatically segmented, for example into subcellular compartments, from images of compartmental markers. Then, the distribution of a target molecule on each of these compartments is calculated that includes the percentage and strength of expression. This is different than existing intensity or ratio based methods where abundant low expression levels are indistinguishable from scarce high expression levels.

Abstract: A method and system for registering two images is described. The method comprises synthesizing projections from two volumetric images to be registered, estimating a plurality of two dimensional (2D) deformable fields from the projections and generating a three dimensional (3D) deformable fields using a plurality of backprojections of the 2D deformable fields.

Abstract: A method of imaging comprises performing a scout image of an object and aligning major regions of interest within the object by comparing the scout image with a pre-determined atlas image. In a further embodiment, a method of imaging using a computed tomography (CT) scanner is provided and comprises performing a scout image of a subject and aligning major anatomical regions of interest within the subject by comparing the scout image with a pre-determined atlas image.

Abstract: Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.

Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Abstract: Sound insulating systems including viscoelastic foams are described. The sound insulating system includes a sound-absorbing layer. The sound-absorbing layer can include viscoelastic foams. An optional barrier layer is adjacent to the sound-absorbing layer. Additionally, an optional substrate layer is adjacent to the sound-absorbing layer, and is spaced and opposed from the optional barrier layer. The sound insulating system is particularly well adapted to be employed as vehicle dashmats.

Abstract: The present invention relates to a sound insulating system. The sound insulating system comprises a first sound absorbing layer. A barrier layer is positioned adjacent the first sound absorbing layer. A second absorbing layer is also provided and is adjacent the barrier layer.

Abstract: A vehicle wheel well assembly is provided and is adapted to engage a vehicle floor pan. The wheel well assembly includes a floor and an annular sidewall extending upwardly from the periphery of the floor. A post extends upwardly from the center of the floor for engaging the spare wheel assembly. A threaded connector extends upwardly from the post for threaded engagement with a receptacle on a top. The sidewall terminates in either a mounting flange or a deck. When connected to a deck, the deck includes a mounting flange. The floor and sidewalls are integrally formed preferably of a composite material. A storage space is created in the area of the post. A method of securing a vehicle wheel well assembly in a vehicle is also provided.

Abstract: A vehicle wheel well assembly is provided and is adapted to engage a vehicle floor pan. The wheel well assembly includes a floor and an annular sidewall extending upwardly from the periphery of the floor. A post extends upwardly from the center of the floor for engaging the spare wheel assembly. A threaded connector extends upwardly from the post for threaded engagement with a receptacle on a top. The sidewall terminates in either a mounting flange or a deck. When connected to a deck, the deck includes a mounting flange. The floor and sidewalls are integrally formed preferably of a composite material. A method of securing a vehicle wheel well assembly in a vehicle is also provided.