Abstract: Embodiments of the present disclosure provide a collapsible wheelchair, including: a movable chassis; a chair; a chair backrest; at least one first folding mechanism, installed between the movable chassis and the chair; and at least one second folding mechanism, connected between the chair and the chair backrest; where, the at least one first folding mechanism and the at least one second folding mechanism are connected in series and both have a four-rod linkage structure, and when the collapsible wheelchair is switched from a folded state to an open state or from the open state to the folded state, the at least one first folding mechanism and the at least one second folding mechanism are configured to move simultaneously. The collapsible wheelchair provided by the present disclosure is convenient in terms of the operation and easy to operate.

Abstract: Mitoxantrone hydrochloride liposome is a unique active ingredient for preparing drugs for treating breast cancer. The breast cancer is preferably advanced breast cancer. A method for treating the breast cancer includes to administer mitoxantrone hydrochloride liposome in a therapeutic effective amount to breast cancer patients, and the therapeutic effective amount means 8-30 mg/m2, according to mitoxantrone. Clinical trial results show that the mitoxantrone hydrochloride liposome has better efficacy and fewer adverse reactions, and especially significantly reduced cardiotoxicity, compared with a common mitoxantrone hydrochloride injection.

Abstract: A pharmaceutical composition comprising: i) a herpes gE protein, an active fragment of the protein, a variant of the protein, or a mixture of at least two of them; ii) an immunostimulatory composition comprising a saponin and a CpG oligodeoxynucleotide, or consisting of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide. Use of the pharmaceutical composition in the preparation of a medicament for preventing and/or treating a varicella-zoster virus infection and/or a varicella-zoster virus mediated disease. The pharmaceutical composition achieves an unexpected technical effect and can mediate a stronger immune response.

Abstract: The present disclosure relates to systems and methods for object recognition. The systems may obtain image data captured by an imaging device. The image data may include one or more objects. The systems may determine a centerline of a target object in the one or more objects based on the image data. The systems may determine a recognition result of the target object using a trained neural network model based on at least one feature parameter of the centerline of the target object. The recognition result may include a name of the target object. The systems may perform an anomaly detection on the target object based on the recognition result of the target object.

Abstract: The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

Abstract: An integrated circuit includes a first cell, a second cell, a buffer zone and a first power rail. The first cell includes a first set of fins extending in a first direction. Each fin of the first set of fins corresponds to a transistor of a first set of transistors. The second cell includes a second set of fins extending in the first direction. Each fin of the second set of fins corresponds to a transistor of a second set of transistors. The second set of fins is separated from the first set of fins in a second direction. The buffer zone is between the first cell and the second cell. The first power rail extends in the first direction, and overlaps at least the buffer zone. The first power rail is in a first metal layer, and is configured to supply a first voltage.

Abstract: The present invention discloses a number of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

Abstract: Methods for depositing a dielectric oxide layer atop one or more substrates disposed in or processed through a PVD chamber are provided herein. In some embodiments, such a method includes: sputtering source material from a target assembly onto a first substrate while the source material is at a first erosion state and while providing a first amount of RF power to the target assembly to deposit a dielectric oxide layer onto a first substrate having a desired resistance-area; and subsequently sputtering source material from the target assembly onto a second substrate while the source material is at a second erosion state and while providing a second amount of RF power to the target assembly, wherein the second amount of RF power is lower than the first amount of RF power by a predetermined amount calculated to maintain the desired resistance-area.

Abstract: Aminopyrimidine containing compounds that inhibit both Mer tyrosine kinase (MerTK) activity and Tyro3 kinase activity are disclosed herein. Additionally disclosed are methods of synthesis and use of the aminopyrimidine containing compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents.

Abstract: The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

Abstract: To generate training data based on normal content and anomalous content generated from the normal content. A training data generation method for generating training data used for generating a learned model for determining whether there is an anomaly in an inspection target, the training data generation method including: receiving normal content regarding the inspection target and anomalous content generated from the normal content; and generating training data based on a set of the normal content and one or more pieces of the anomalous content.

Abstract: This application disclosures a method and system for detecting a centerline of a vessel. The method may include obtaining image data, wherein the image data may include vessel data; selecting two endpoints of the vessel based on the vessel data; transforming the image data to generate a transformed image based on at least one image transformation function; and determining a path of the centerline of the vessel connecting the first endpoint of the vessel and the second endpoint of the vessel to obtain the centerline of the vessel based on the transformed image. The two endpoints of the vessel may include a first endpoint of the vessel and a second endpoint of the vessel.

Abstract: Embodiments of the disclosure provide systems and methods for providing random access to segmented and encrypted or compressed data stored in a repository. Retrieving at least a portion of a file stored in a repository can comprise storing a plurality of files in the repository. A request to retrieve at least a portion of one of the plurality of files can be received and object metadata for the requested one of the plurality of files can be obtained. A determination can be made based on the obtained metadata as to whether the requested one of the plurality of files is a multipart file. In response to determining the requested one of the plurality of files is not a multipart file, a single file retrieval process performing and in response to determining the requested one or the plurality of files is a multipart file, a multipart retrieval process can be performed.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: An aluminum alloy based on a total weight of the aluminum alloy, in percentages by weight, includes 9.12% of Si, 8-11% of Zn, 0.5-1.5% of Mg, 0.2-0.8% of Cu, 0-0.6% of Fe, 0.08-0.25% of Mn, 0-0.10% of Sr, 0-0.05% of Sc, 0-0.5% of Er, and 73.2-82.22% of Al.

Abstract: A method of forming a tunnel layer of a magnetoresistive random-access memory (MRAM) structure includes forming a first magnesium oxide (MgO) layer by sputtering an MgO target using radio frequency (RF) power, exposing the first MgO layer to oxygen for approximately 5 seconds to approximately 20 seconds at a flow rate of approximately 10 sccm to approximately 15 sccm, and forming a second MgO layer on the first MgO layer by sputtering the MgO target using RF power. The method may be performed after periodic maintenance of a process chamber to increase the tunnel magnetoresistance (TMR) of the tunnel layer.

Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Abstract: An array substrate, a method for manufacturing an array substrate, and a display device are provided. The array substrate includes a first substrate, a first common electrode layer, a second common electrode layer, a frame sealing adhesive and a conductive adhesive. The first common electrode layer is disposed at an edge of the first substrate and is in a grid shape; the second common electrode layer is disposed at an inner side the first common electrode layer, and includes a light-transmitting portion provided in a grid shape, and a gate insulating layer is provided on the light-transmitting portion. The frame sealing adhesive is disposed on the first common electrode layer. The conductive adhesive is disposed in the frame sealing adhesive and partially extends onto the gate insulating layer corresponding to the light-transmitting portion. The conductive adhesive is configured to electrically connect with a common electrode of a color filter substrate.

Abstract: The present disclosure relates to systems and methods for image processing. The methods may include determining structure data associated with the tissue based on at least one original image of a tissue. The methods may further include determining at least one stenosis region of the tissue based on the structure data associated with the tissue. At least one of the structure data and/or the at least one stenosis region of the tissue may be configured to be displayed on a display device.