Patents by Inventor Xiaofan Dong

Xiaofan Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Three dimensional format biochips
    Patent number: 7638464
    Abstract: A biochip is formed with a plurality of optically clear hydrogel cells attached to the top surface of a solid substrate in the form of an array. Each of the cells is formed of a hydrogel of polyethylene glycol, polypropylene glycol or a copolymer thereof having reactive isocyanate groups. Binding entities are immobilized in these cells, which entities are effective to selectively hybridize to or sequester a target biomolecule. Different binding entities are immobilized in different cells in an array to create a biochip that can be used to assay for a number of target biomolecules.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: December 29, 2009
    Assignee: Biocept, Inc.
    Inventors: Roberto Fagnani, Soonkap Hahn, Xiaofan Dong, Tony Pircher, Sandra Matsumoto, Pavel Tsinberg
  • METHODS AND GEL COMPOSITIONS FOR ENCAPSULATING LIVING CELLS AND ORGANIC MOLECULES
    Publication number: 20070141164
    Abstract: A method for encapsulating biologics within a hydrogel by using an aqueous solution of an isocyanate-functional polyurethane prepolymer which is mixed with an amount of biologics and an aqueous solution containing a dithiol crosslinking agent under physiological pH conditions to create a hydrogel. An additional bidentate crosslinking agent is optionally included. The product of such method may be a bioreactor or an assay device having a plurality of different biologics encapsulated at predetermined locations in a substrate.
    Type: Application
    Filed: February 1, 2007
    Publication date: June 21, 2007
    Applicant: BIOCEPT, INC.
    Inventors: Soonkap Hahn, Roberto Fagnani, Xiaofan Dong, Carl Edman, Pavel Tsinberg
  • Methods and gel compositions for encapsulating living cells and organic molecules
    Patent number: 7172866
    Abstract: A method for encapsulating biologics within a hydrogel by using an aqueous solution of an isocyanate-functional hydrogel prepolymer which is mixed with an amount of biologics and an aqueous solution containing a dithiol crosslinking agent under physiological pH conditions. An additional bidentate crosslinking agent may be included. The product of such method may be a bioreactor or an assay device having a plurality or different biologics encapsulated at predetermined locations in a substrate.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: February 6, 2007
    Assignee: Biocept, Inc.
    Inventors: Soonkap Hahn, Roberto Fagnani, Xiaofan Dong, Carl F. Edman, Pavel Tsinberg
  • Three dimensional format biochips
    Publication number: 20050037343
    Abstract: A biochip is formed with a plurality of optically clear hydrogel cells attached to the top surface of a solid substrate in the form of an array. Each of the cells is formed of a hydrogel of polyethylene glycol, polypropylene glycol or a copolymer thereof having reactive isocyanate groups. Binding entities are immobilized in these cells, which entities are effective to selectively hybridize to or sequester a target biomolecule. Different binding entities are immobilized in different cells in an array to create a biochip that can be used to assay for a number of target biomolecules.
    Type: Application
    Filed: October 25, 2001
    Publication date: February 17, 2005
    Inventors: Roberto Fagnani, Soonkap Hahn, Xiaofan Dong, Tony Pircher, Sandra Matsumoto, Pavel Tsinberg
  • Methods and gel compositions for encapsulating living cells and organic molecules
    Publication number: 20040029241
    Abstract: A method for encapsulating biologics within a hydrogel by using an aqueous solution of an isocyanate-functional hydrogel prepolymer which is mixed with an amount of biologics and an aqueous solution containing a dithiol crosslinking agent under physiological pH conditions. An additional bidentate crosslinking agent may be included. The product of such method may be a bioreactor or an assay device having a plurality or different biologics encapsulated at predetermined locations in a substrate.
    Type: Application
    Filed: April 8, 2003
    Publication date: February 12, 2004
    Inventors: Soonkap Hahn, Roberto Fagnani, Xiaofan Dong, Carl F Edman, Pavel Tsinberg