Abstract: Disclosed in the present invention is an anti-Nipah virus monoclonal antibody having neutralization activity. The antibody consists of a monkey-derived variable region and a human constant region, and both light and heavy chains of the monkey-derived variable region have unique CDR regions. The antibody provided by the present invention has an excellent antigen binding capability, and has good binding activity with Bangladesh Nipah virus and Malaysia Nipah virus glycoprotein G. The antibody can effectively neutralize the Nipahpseudovirus. Moreover, the neutralization activity of the antibody is enhanced as the concentration of the antibody increases, and nearly 100% neutralization of the Nipahpseudovirus can be achieved at a concentration of 1 ?g/mL. Also disclosed in the present invention is an application of the monoclonal antibody against the Nipah virus glycoprotein G in preparation of a Nipah virus treatment drug.

Abstract: Provided is use of an antibody-drug conjugate targeting Her2 in the preparation of a medicine for treating breast cancer patients with liver metastasis or breast cancer patients without lung metastasis. Compared with a control drug group (lapatinib+capecitabine), the application of the antibody-drug conjugate provided in the treatment of breast cancer patients with liver metastasis and in the treatment of breast cancer patients without lung metastasis can significantly improve the survival time of the patients.

Abstract: An illumination system for a STED optical microscope includes an illumination light path consisting of an illumination light source and an optical elements. The illumination light path includes a first light filter, a second light filter, a polarizing light splitter, a first quarter wave plate, a first dichroic element, a light path delay unit, a phase plate, a second dichroic element, and a second quarter wave plate arranged in sequence along the transmission direction of the light path. The light beam emitted from the illumination light source is divided into two coaxial light beams after transmitted by the illumination light path. A first light beam is incident to a microscope objective to form a first light spot, a second light beam is incident to the microscope objective to form a second light spot, and the center of the first light spot coincides with that of the second light spot.

Abstract: An illumination system for a STED optical microscope includes an illumination light path consisting of an illumination light source and an optical element. The illumination light path includes a first light filter, a second light filter, a polarizing light splitter, a first quarter wave plate, a first dichroic element, a light path delay unit, a phase plate, a second dichroic element, and a second quarter wave plate arranged in sequence along the transmission direction of the light path. The light beam emitted from the illumination light source is divided into two coaxial light beams after transmitted by the illumination light path. A first light beam is incident to a microscope objective to form a first light spot, a second light beam 12 is incident to the microscope objective to form a second light spot, and the center of the first light spot coincides with that of the second light spot.

Abstract: The present invention relates to a composition as a transforming growth factor (TGF)-? suppressor which comprises an effective amount of guanidine compound or a pharmaceutically acceptable salt. More particularly, the present invention relates to a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-? suppressor, wherein the composition is characterized by suppression or reduction of TGF-? activity which is a cause of disease. The present invention relates to a method of treating various TGF-? associated diseases, the method comprising administering to the subject a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-? suppressor which can prevent or treat TGF-? associated diseases by suppressing or reducing TGF-? activity.

Abstract: A white-light organic electroluminescent material based on 8-hydroxyquinoline and the method for preparing the same, as well as an organic light emitting diode including this material. The material may be the compound represented by the Formula (IX) having a DCDC group, a 5-position substituted 8-hydroxyquinolinyl group and a carbazolyl group as red light-, green light- and blue-light emitting groups, respectively. It exhibits a spectrum having a band width of 182.4 nm that substantially covers the visible-light region, and has a color coordinate of (0.3177, 0.3946), which just locates within the white-light area. Such a material is capable of realizing a white-light emission, and may be used in a white-light OLED as a single light-emitting layer, which can decrease the number of layers of the white-light OLED and thereby improve the luminous efficiency, stabilize the light color, lower the turn-on voltage and simplify the fabrication process.

Abstract: A white-light organic electroluminescent material based on 8-hydroxyquinoline and the method for preparing the same, as well as an organic light emitting diode including this material. The material may be the compound represented by the Formula (IX) having a DCDC group, a 5-position substituted 8-hydroxyquinolinyl group and a carbazolyl group as red light-, green light- and blue-light emitting groups, respectively. It exhibits a spectrum having a band width of 182.4 nm that substantially covers the visible-light region, and has a color coordinate of (0.3177, 0.3946), which just locates within the white-light area. Such a material is capable of realizing a white-light emission, and may be used in a white-light OLED as a single light-emitting layer, which can decrease the number of layers of the white-light OLED and thereby improve the luminous efficiency, stabilize the light color, lower the turn-on voltage and simplify the fabrication process.