Abstract: Disclosed by the present invention is a multi-hazard accident coupling three-dimensional simulation system for a major oil and gas infrastructure, including an accident three-dimensional simulation module, an accident chain evolution prediction module, a model unit, and a database module. On the basis of an existing Natech accident analysis method, a Natech accident multi-hazard coupling link of a major infrastructure for oil and gas storage and transportation is considered, and all potential accident link possibilities are identified. In daily management, the accident probabilities and accident consequences of various units under multi-hazard coupling are analyzed to provide a basis for reasonable arrangement of safety protection facilities and emergency evacuation drill.