Patents by Inventor Xiao-Jun Li

Xiao-Jun Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11913957
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: February 27, 2024
    Assignee: Biodesix, Inc.
    Inventors: Paul E. Kearney, Kenneth C. Fang, Xiao-Jun Li, Clive Hayward, Douglas Spicer
  • Patent number: 11467167
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: October 11, 2022
    Assignee: Biodesix, Inc.
    Inventors: Paul E. Kearney, Xiao-Jun Li, Clive Hayward
  • Publication number: 20220170938
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Application
    Filed: September 9, 2021
    Publication date: June 2, 2022
    Inventors: Paul E. Kearney, Kenneth C. Fang, Xiao-Jun Li, Clive Hayward, Douglas Spicer
  • Patent number: 11193935
    Abstract: The present invention provides methods for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. The present invention also provides compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: December 7, 2021
    Assignee: Biodesix, Inc.
    Inventors: Paul Edward Kearney, Kenneth Charles Fang, Xiao-Jun Li, Clive Hayward
  • Publication number: 20210285950
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Application
    Filed: October 13, 2020
    Publication date: September 16, 2021
    Inventors: Paul E. Kearney, Kenneth C. Fang, Xiao-Jun Li, Clive Hayward
  • Patent number: 11041495
    Abstract: A positive displacement compressor includes a positive displacement compressor rotor; a shaft operative to support the positive displacement compressor rotor; a bearing operative to support the shaft; a first structure having a first squeeze film compression surface; and a second structure having a second squeeze film compression surface spaced apart radially from the first squeeze film compression surface. The first and second structures are constructed to jointly form a squeeze film damper using the first and second squeeze film compression surfaces. The squeeze film damper is operative to provide squeeze film damping of vibrations. An annular oil discharge groove is disposed adjacent to a first end of the squeeze film damper. A first o-ring gland houses a circumferential-sealing o-ring disposed proximate to the first end of the squeeze film damper. A second o-ring gland houses a second circumferential-sealing o-ring disposed proximate to a second end of the squeeze film damper.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: June 22, 2021
    Assignee: INGERSOLL-RAND INDUSTRIAL U.S., INC.
    Inventors: Yi Liu, Blake Leary, Xiao Jun Li, Yun Feng Zhang
  • Publication number: 20200348310
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Application
    Filed: December 4, 2019
    Publication date: November 5, 2020
    Inventors: Paul E. Kearney, Xiao-Jun Li, Clive Hayward
  • Patent number: 10802027
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: October 13, 2020
    Assignee: Biodesix, Inc.
    Inventors: Paul Edward Kearney, Kenneth Charles Fang, Xiao-Jun Li, Clive Hayward
  • Patent number: 10534002
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: January 14, 2020
    Assignee: Biodesix, Inc.
    Inventors: Paul Edward Kearney, Xiao-Jun Li, Clive Hayward, Miguel Dominguez Geeraerts
  • Patent number: 10338074
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: July 2, 2019
    Assignee: Biodesix, Inc.
    Inventors: Paul Edward Kearney, Kenneth Charles Fang, Xiao-Jun Li, Clive Hayward
  • Publication number: 20190186492
    Abstract: A positive displacement compressor includes a positive displacement compressor rotor; a shaft operative to support the positive displacement compressor rotor; a bearing operative to support the shaft; a first structure having a first squeeze film compression surface; and a second structure having a second squeeze film compression surface spaced apart radially from the first squeeze film compression surface. The first and second structures are constructed to jointly form a squeeze film damper using the first and second squeeze film compression surfaces. The squeeze film damper is operative to provide squeeze film damping of vibrations. An annular oil discharge groove is disposed adjacent to a first end of the squeeze film damper. A first o-ring gland houses a circumferential-sealing o-ring disposed proximate to the first end of the squeeze film damper. A second o-ring gland houses a second circumferential-sealing o-ring disposed proximate to a second end of the squeeze film damper.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 20, 2019
    Inventors: Yi Liu, Blake Leary, Xiao Jun Li, Yun Feng Zhang
  • Publication number: 20190056402
    Abstract: The present application provides novel compositions, methods, and assays for use in identification of appropriate diagnostic markers in blood. These compositions, methods, and assays are capable of distinguishing normal levels of detectable markers from changes in marker levels that are indicative of changes in health status.
    Type: Application
    Filed: July 23, 2018
    Publication date: February 21, 2019
    Inventors: Xiao-Jun Li, Paul Kearney
  • Publication number: 20180284128
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Application
    Filed: June 7, 2018
    Publication date: October 4, 2018
    Inventors: Paul Edward Kearney, Xiao-Jun Li, Clive Hayward
  • Publication number: 20180067119
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Application
    Filed: October 18, 2017
    Publication date: March 8, 2018
    Inventors: Paul Edward KEARNEY, Kenneth Charles FANG, Xiao-Jun LI, Clive HAYWARD, Douglas SPICER
  • Publication number: 20180059113
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Application
    Filed: May 5, 2017
    Publication date: March 1, 2018
    Inventors: Paul Edward KEARNEY, Kenneth Charles Fang, Xiao-Jun Li, Clive Hayward
  • Publication number: 20180011099
    Abstract: The present invention provides methods for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. The present invention also provides compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
    Type: Application
    Filed: August 18, 2017
    Publication date: January 11, 2018
    Inventors: Paul Edward Kearney, Kenneth Charles Fang, Xiao-Jun Li, Clive Hayward
  • Publication number: 20180003724
    Abstract: Novel compositions, methods, assays and kits directed to a diagnostic panel for Alzheimer's disease are provided. In one embodiment, the diagnostic panel includes one or more proteins associated with Alzheimer's disease.
    Type: Application
    Filed: August 24, 2017
    Publication date: January 4, 2018
    Inventors: Xiao-Jun LI, Paul Edward KEARNEY
  • Publication number: 20170299605
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Inventors: Paul Edward Kearney, Xiao-Jun Li, Clive Hayward
  • Publication number: 20170299604
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Application
    Filed: November 18, 2016
    Publication date: October 19, 2017
    Inventors: Paul Edward Kearney, Xiao-Jun Li, Clive Hayward
  • Publication number: 20170269090
    Abstract: Presented herein are compositions, methods, and kits for determining whether a pulmonary nodule is cancer and/or is not cancer.
    Type: Application
    Filed: March 13, 2017
    Publication date: September 21, 2017
    Inventors: Paul Edward KEARNEY, Xiao-Jun Li, Clive Hayward