Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation or IDH2 mutation.

Abstract: A bumper bearing assembly includes a bearing housing having a level of radial spring stiffness, wherein the bearing housing defines a bearing seat. A bumper bearing is connected to the bearing housing by a spring having a level of radial spring stiffness lower than that of the bearing housing. The bumper bearing is configured to apply the level of radial spring stiffness of the spring against a rotor with the bumper bearing spaced apart from the bearing seat. The bearing housing is configured to apply the level of radial spring stiffness of the bearing housing against the rotor with the bumper bearing seated against the bearing seat.

Abstract: A rotor blade comprises a blade platform and an airfoil. The airfoil comprises a blade tip, a leading edge, and a trailing edge with a stiffening compound lean contour. The blade tip is radially opposite the blade platform, and defines a blade span between the blade itself and the blade platform. The leading and trailing edges extend from the blade platform to the blade tip to define blade chords between the leading edge and the trailing edge. The compound lean contour comprises a positive lean section located at the lean tip, and extending along a lean axis to a lean end. The negative lean section is located radially inward of the positive lean section, and extends along the lean axis to the lean end.

Abstract: A two-speed automatic planetary transmission, including a sun gear, dual planet gears, a planet carrier, a ring gear, a band-type brake ring, and a locking ring. The locking ring is disposed between the outer surface of the ring gear and the inner surface of the annular lug boss, and the inner surface of the locking ring is fixedly connected to the outer surface of the ring gear. Part of the outer surface of the locking ring contacts with the inner surface of the annular lug boss, and another part thereof is sheathed with the band-type brake ring. One end of the band-type brake ring is a fixed end, and is fixedly connected to a transmission shell; and another one is an unfixed end which is connected to a gear shifting actuator.

Abstract: A gas turbine engine is provided comprising an impeller configured to rotate about an axis. A combustor is in fluid communication with the impeller. An inflow radial turbine is aft of the impeller and in fluid communication with the combustor. The inflow radial turbine includes a rotor with a bore having a flat bore end configured to rotate about the axis. A radial turbine is also provided comprising a rotor configured to rotate about an axis and a bore defined by a proximal portion of the rotor. The bore may have a flat bore end. A rotor is further provided comprising a disk configured to rotate about an axis and a bore partially through the disk along the axis. The bore may comprise a flat section extending radially from the axis and a curved section aft of the flat section.

Abstract: A brush seal land is disclosed. The brush seal land may comprise a first portion configured to be coupled to a turbine disc of an aircraft engine and a second portion having a contact surface. The brush seal land may comprise a concave annular structure. The second portion may deflect through a clearance area in response to contact with a brush. The second portion may not deflect in response to contact with a brush after the second portion has deflected through a clearance area in response to contact with the brush. The contact surface comprises tungsten carbide. The brush seal land may comprise INCONEL. The brush seal land may be configured to be coupled to an annular member extending from the turbine disc. The brush seal land may reduce abrasion to an annular member extending from the turbine disc by a brush.

Abstract: A bearing support assembly includes a squirrel cage defining a longitudinal axis and having a cylindrical portion defining a bearing seat. The squirrel cage is configured and adapted to provide a first level of radial support stiffness between a housing and a bearing seated in the bearing seat. A damper sleeve is operatively coupled to the cylindrical portion of the squirrel cage through a fluid film to dampen relative radial motion between the damper sleeve and the squirrel cage. A radial spring component is operatively connected to a side of the damper sleeve radially opposite the cylindrical portion of the squirrel cage to provide a second level of radial support stiffness.

Abstract: The present disclosure is applicable to all gear trains using a journal bearing as a means of supporting gear shaft rotation. It is related in some embodiments to a system and method for supplying lubricant to the journal bearings of a gear-turbofan engine gear train when the fan rotor is subjected to a wind-milling condition in both directions, either clockwise or counter-clockwise.

Abstract: A fuel injector for a combustor of a gas turbine engine includes an air swirler adjacent to a pressure atomizer.

Abstract: The present disclosure relates generally a gas turbine engine and a rotor therefor. The rotor may include a symmetric rim thereon to prevent the propagation of induced vibratory responses. The rim may have one or more sloping surfaces to prevent the re-attachment of boundary layer flow.

Abstract: A diaphragm assembly includes a cylinder, a circular flange, and a diaphragm. The cylinder defines an axis and includes a first end and a second end opposite the first end. The circular flange is coaxial with the cylinder and at a greater radial distance from the axis than the cylinder. The diaphragm extends from the second end of the cylinder to the flange.

Abstract: A turbine wheel is disposed about an axis and has a back having a separator disposed thereon, an inner undercut disposed between the separator and the axis, and an outer undercut disposed between the separator and an outer periphery of the back face. The inner undercut is defined by a first radius blending toward the axis and into a first flat section, and further defined by a second radius blending into the first flat section and into the separator.

Abstract: An airfoil includes a blade having a pocket recess therein and one or more features disposed within the pocket recess. The one or more features are configured to disrupt pressure oscillations within the pocket recess. In another embodiment, a blade is disclosed having a first wall and a second wall. The first wall is disposed on a suction side of the blade and the second wall is disposed on a pressure side of the blade. The second wall is connected to the first wall at a leading edge of the blade. Together the first wall and the second wall form a portion of a pocket recess and the pocket recess is disposed asymmetrically with respect to a camber line of the blade.

Abstract: A method for controlling a flow of fuel to a starting gas turbine engine includes controlling the flow of fuel to the engine by controlling fuel pressure to the engine, and modulating the flow of fuel to the engine if engine exhaust gas temperature approaches a given exhaust gas temperature to lower the engine exhaust gas temperature below the given exhaust gas temperature.

Abstract: A turbine blade comprises an airfoil having a pressure side and a suction side, and extending from a leading edge to a trailing edge. The airfoil has a tip remote from a mounting root, and a pocket extending inwardly of the tip. The pocket has spaced walls with one wall associated with the pressure side of the airfoil, and an opposed wall associated with the suction side. A pin extends across the pocket and connects the opposed walls. A slot is formed in the pin at a location intermediate ends of the pin which connect to the opposed walls. A method for identifying a location for the pin along a distance between a leading edge and a trailing edge of the pocket utilizes a modal analysis, and seeks to find a location where both a reaction force and a moment are lower than they might be at other locations.

Abstract: A rotor for a gas turbine engine includes a plurality of turbine blades extending radially outwardly of a rotor body. A plurality of purge blades are positioned to rotate with the rotor body, and to drive air radially outwardly toward the turbine blades.

Abstract: A disc with two sides includes a hub having a bore and a bore radius, a neck, and a rim. The neck is connected to and radially outward of the hub and has an inner wedge with a curved section on one side of the disc, an outer wedge with a curved section on that same side of the disc, and a center section between the wedges with a flat side on that same side of the disc. The rim is connected to and radially outward of the neck, the rim having a radius that is no more than seven times greater than the bore radius.

Abstract: An example method of designing blade lobes of a turbomachine blade and corresponding disk lobes includes determining contact areas between the blade lobes on a blade model and the disk loads on a disk model when the turbomachine blade is in a loaded position. The method adjusts the blade lobes, the disk lobes, or both, so that gaps are established between the blade lobes and the disk lobes at the contact areas when the turbomachine blade is in an unloaded position. The size of the gaps varies.

Abstract: A diaphragm assembly includes a cylinder, a circular flange, and a diaphragm. The cylinder defines an axis and includes a first end and a second end opposite the first end. The circular flange is coaxial with the cylinder and at a greater radial distance from the axis than the cylinder. The diaphragm extends from the second end of the cylinder to the flange.

Abstract: A variable vane system includes a plurality of vanes each being pivotal about an axis. A mechanical linkage drives the plurality of vanes to rotate about the axis. The mechanical linkage includes a ring gear to rotate, and in turn drive the plurality of vanes. There is at least one rod to drive the ring gear to rotate. The rod is driven by a hydraulic servo motor. A spring bias force is provided in the mechanical linkage to resist either translational or rotational oscillation.